mtus2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

mtus2

Uncharacterized protein. (1171 aa)

Predicted Functional Partners:

bub3

0.584

mapre1

0.550

nudc

0.543

dctn2

0.539

mapre2

0.539

ENSPREP00000020403

0.539

Kif17

0.539

LOC103458373

0.539

ENSPREP00000023746

0.539

LOC103457273

0.539

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000020403	Kif17	ENSPREP00000020403	ENSPREP00000020430	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.925
ENSPREP00000020403	LOC103457273	ENSPREP00000020403	ENSPREP00000024330	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 3b.	0.587
ENSPREP00000020403	LOC103458373	ENSPREP00000020403	ENSPREP00000022449	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 3a.	0.587
ENSPREP00000020403	bub3	ENSPREP00000020403	ENSPREP00000010595	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	BUB3 mitotic checkpoint protein.	0.677
ENSPREP00000020403	dctn2	ENSPREP00000020403	ENSPREP00000011849	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Dynactin 2 (p50).	0.645
ENSPREP00000020403	mapre1	ENSPREP00000020403	ENSPREP00000002608	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 1b.	0.587
ENSPREP00000020403	mapre2	ENSPREP00000020403	ENSPREP00000012785	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 2.	0.587
ENSPREP00000020403	mtus2	ENSPREP00000020403	ENSPREP00000020621	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.539
ENSPREP00000020403	nudc	ENSPREP00000020403	ENSPREP00000021892	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	NudC nuclear distribution protein.	0.612
ENSPREP00000023746	LOC103457273	ENSPREP00000023746	ENSPREP00000024330	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 3b.	0.587
ENSPREP00000023746	LOC103458373	ENSPREP00000023746	ENSPREP00000022449	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 3a.	0.587
ENSPREP00000023746	bub3	ENSPREP00000023746	ENSPREP00000010595	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	BUB3 mitotic checkpoint protein.	0.832
ENSPREP00000023746	dctn2	ENSPREP00000023746	ENSPREP00000011849	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Dynactin 2 (p50).	0.753
ENSPREP00000023746	mapre1	ENSPREP00000023746	ENSPREP00000002608	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 1b.	0.587
ENSPREP00000023746	mapre2	ENSPREP00000023746	ENSPREP00000012785	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 2.	0.587
ENSPREP00000023746	mtus2	ENSPREP00000023746	ENSPREP00000020621	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.539
ENSPREP00000023746	nudc	ENSPREP00000023746	ENSPREP00000021892	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	NudC nuclear distribution protein.	0.679
Kif17	ENSPREP00000020403	ENSPREP00000020430	ENSPREP00000020403	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.925
Kif17	LOC103457273	ENSPREP00000020430	ENSPREP00000024330	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 3b.	0.587
Kif17	LOC103458373	ENSPREP00000020430	ENSPREP00000022449	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microtubule-associated protein, RP/EB family, member 3a.	0.587

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

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