LOC103471489 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LOC103471489

Uncharacterized protein. (315 aa)

Predicted Functional Partners:

cd79a

0.559

LOC103481840

0.555

tyrobp

0.413

ptpn6

0.412

LOC103467098

0.412

ptpn11

0.412

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103467098	LOC103471489	ENSPREP00000016883	ENSPREP00000020992	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.412
LOC103467098	LOC103481840	ENSPREP00000016883	ENSPREP00000016438	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Ig-like domain-containing protein.	0.521
LOC103467098	cd79a	ENSPREP00000016883	ENSPREP00000021581	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	CD79a molecule, immunoglobulin-associated alpha.	0.490
LOC103467098	ptpn11	ENSPREP00000016883	ENSPREP00000024560	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
LOC103471489	LOC103467098	ENSPREP00000020992	ENSPREP00000016883	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.412
LOC103471489	LOC103481840	ENSPREP00000020992	ENSPREP00000016438	Uncharacterized protein.	Ig-like domain-containing protein.	0.555
LOC103471489	cd79a	ENSPREP00000020992	ENSPREP00000021581	Uncharacterized protein.	CD79a molecule, immunoglobulin-associated alpha.	0.559
LOC103471489	ptpn11	ENSPREP00000020992	ENSPREP00000024560	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.412
LOC103471489	ptpn6	ENSPREP00000020992	ENSPREP00000016776	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.412
LOC103471489	tyrobp	ENSPREP00000020992	ENSPREP00000004201	Uncharacterized protein.	Uncharacterized protein.	0.413
LOC103481840	LOC103467098	ENSPREP00000016438	ENSPREP00000016883	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.521
LOC103481840	LOC103471489	ENSPREP00000016438	ENSPREP00000020992	Ig-like domain-containing protein.	Uncharacterized protein.	0.555
LOC103481840	cd79a	ENSPREP00000016438	ENSPREP00000021581	Ig-like domain-containing protein.	CD79a molecule, immunoglobulin-associated alpha.	0.998
LOC103481840	ptpn11	ENSPREP00000016438	ENSPREP00000024560	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.521
LOC103481840	ptpn6	ENSPREP00000016438	ENSPREP00000016776	Ig-like domain-containing protein.	Protein tyrosine phosphatase non-receptor type 6.	0.521
cd79a	LOC103467098	ENSPREP00000021581	ENSPREP00000016883	CD79a molecule, immunoglobulin-associated alpha.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.490
cd79a	LOC103471489	ENSPREP00000021581	ENSPREP00000020992	CD79a molecule, immunoglobulin-associated alpha.	Uncharacterized protein.	0.559
cd79a	LOC103481840	ENSPREP00000021581	ENSPREP00000016438	CD79a molecule, immunoglobulin-associated alpha.	Ig-like domain-containing protein.	0.998
cd79a	ptpn11	ENSPREP00000021581	ENSPREP00000024560	CD79a molecule, immunoglobulin-associated alpha.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.490
cd79a	ptpn6	ENSPREP00000021581	ENSPREP00000016776	CD79a molecule, immunoglobulin-associated alpha.	Protein tyrosine phosphatase non-receptor type 6.	0.490

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.925

expected number of edges:

11

PPI enrichment p-value:

1.31e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006312

Mitotic recombination

6 of 20

2.79

6.33

8.67e-13

GO:0006310

DNA recombination

10 of 176

2.07

6.2

8.80e-17

GO:0000724

Double-strand break repair via homologous recombination

8 of 89

2.27

6.08

3.45e-14

GO:0045003

Double-strand break repair via synthesis-dependent strand annealing

5 of 7

3.17

6.04

8.13e-12

GO:0006302

Double-strand break repair

9 of 173

2.03

5.38

2.31e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140664

ATP-dependent DNA damage sensor activity

5 of 18

2.76

4.83

7.97e-10

GO:0008094

ATP-dependent activity, acting on DNA

6 of 107

2.07

3.8

3.86e-09

GO:0003697

Single-stranded DNA binding

4 of 87

1.98

2.16

3.39e-05

GO:0000150

DNA strand exchange activity

2 of 2

3.32

1.9

0.00038

GO:0003677

DNA binding

8 of 2428

0.84

0.71

0.00054

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033061

DNA recombinase mediator complex

5 of 6

3.24

6.17

5.15e-12

GO:0000781

Chromosome, telomeric region

4 of 56

2.17

2.67

4.39e-06

GO:0000228

Nuclear chromosome

5 of 149

1.84

2.48

2.44e-06

GO:0033065

Rad51C-XRCC3 complex

2 of 2

3.32

1.94

0.00032

GO:0032798

Swi5-Sfr1 complex

2 of 2

3.32

1.94

0.00032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35713948

(2022) Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex.

3 of 30

2.32

1.82

0.00037

PMID:24742317

(2014) Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana.

2 of 10

2.62

1.23

0.0057

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

1.02

0.0132

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7057

Homologous DNA Pairing and Strand Exchange, and DNA replication factor A complex

6 of 22

2.75

5.95

4.36e-12

CL:7085

DNA recombination and repair protein Rad51-like, C-terminal

4 of 6

3.14

4.5

6.07e-09

CL:35651

Mixed, incl. Swi5-Sfr1 complex, and TRAM1-like protein

3 of 7

2.95

2.88

5.51e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03440

Homologous recombination

2 of 27

2.19

0.99

0.0141

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5693579

Homologous DNA Pairing and Strand Exchange

4 of 26

2.5

3.1

1.31e-06

MAP-5693568

Resolution of D-loop Structures through Holliday Junction Intermediates

4 of 30

2.44

3.07

1.31e-06

MAP-5693537

Resolution of D-Loop Structures

4 of 30

2.44

3.07

1.31e-06

MAP-5685942

HDR through Homologous Recombination (HRR)

4 of 64

2.11

2.59

5.52e-06

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

5 of 140

1.87

2.56

1.78e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033061

DNA recombinase mediator complex

6 of 7

3.25

7.73

6.11e-15

GOCC:0000228

Nuclear chromosome

5 of 207

1.7

1.99

2.21e-05

GOCC:0033065

Rad51C-XRCC3 complex

2 of 2

3.32

1.89

0.00039

GOCC:0032798

Swi5-Sfr1 complex

2 of 2

3.32

1.89

0.00039

GOCC:0033063

Rad51B-Rad51C-Rad51D-XRCC2 complex

2 of 3

3.14

1.86

0.00044

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020588

DNA recombination and repair protein RecA-like, ATP-binding domain

5 of 6

3.24

5.77

2.90e-11

IPR013632

DNA recombination and repair protein Rad51-like, C-terminal

5 of 6

3.24

5.77

2.90e-11

IPR016467

DNA recombination and repair protein, RecA-like

2 of 2

3.32

1.4

0.0030

IPR010995

DNA repair Rad51/transcription factor NusA, alpha-helical

2 of 2

3.32

1.4

0.0030

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 151

1.74

1.54

0.00050

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 7

2.77

1.4

0.0029

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