ano3 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ano3

Anoctamin. (977 aa)

Predicted Functional Partners:

snap25

0.475

CNOT2

0.473

LOC103470060

0.473

LOC103466190

0.473

cgnl1

0.473

mpzl3

0.472

LOC103478325

0.472

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNOT2	LOC103466190	ENSPREP00000008848	ENSPREP00000030729	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex, subunit 2.	0.901
CNOT2	LOC103470060	ENSPREP00000008848	ENSPREP00000018169	CCR4-NOT transcription complex subunit 2.	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	0.473
CNOT2	LOC103478325	ENSPREP00000008848	ENSPREP00000019375	CCR4-NOT transcription complex subunit 2.	CKLF-like MARVEL transmembrane domain containing 8a.	0.473
CNOT2	ano3	ENSPREP00000008848	ENSPREP00000021094	CCR4-NOT transcription complex subunit 2.	Anoctamin.	0.473
CNOT2	cgnl1	ENSPREP00000008848	ENSPREP00000034334	CCR4-NOT transcription complex subunit 2.	Cingulin-like 1.	0.473
CNOT2	mpzl3	ENSPREP00000008848	ENSPREP00000010247	CCR4-NOT transcription complex subunit 2.	Ig-like domain-containing protein.	0.473
LOC103466190	CNOT2	ENSPREP00000030729	ENSPREP00000008848	CCR4-NOT transcription complex, subunit 2.	CCR4-NOT transcription complex subunit 2.	0.901
LOC103466190	LOC103470060	ENSPREP00000030729	ENSPREP00000018169	CCR4-NOT transcription complex, subunit 2.	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	0.473
LOC103466190	LOC103478325	ENSPREP00000030729	ENSPREP00000019375	CCR4-NOT transcription complex, subunit 2.	CKLF-like MARVEL transmembrane domain containing 8a.	0.473
LOC103466190	ano3	ENSPREP00000030729	ENSPREP00000021094	CCR4-NOT transcription complex, subunit 2.	Anoctamin.	0.473
LOC103466190	cgnl1	ENSPREP00000030729	ENSPREP00000034334	CCR4-NOT transcription complex, subunit 2.	Cingulin-like 1.	0.473
LOC103466190	mpzl3	ENSPREP00000030729	ENSPREP00000010247	CCR4-NOT transcription complex, subunit 2.	Ig-like domain-containing protein.	0.473
LOC103470060	CNOT2	ENSPREP00000018169	ENSPREP00000008848	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	CCR4-NOT transcription complex subunit 2.	0.473
LOC103470060	LOC103466190	ENSPREP00000018169	ENSPREP00000030729	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	CCR4-NOT transcription complex, subunit 2.	0.473
LOC103470060	LOC103478325	ENSPREP00000018169	ENSPREP00000019375	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	CKLF-like MARVEL transmembrane domain containing 8a.	0.472
LOC103470060	ano3	ENSPREP00000018169	ENSPREP00000021094	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	Anoctamin.	0.473
LOC103470060	cgnl1	ENSPREP00000018169	ENSPREP00000034334	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	Cingulin-like 1.	0.472
LOC103470060	mpzl3	ENSPREP00000018169	ENSPREP00000010247	Glycerol-3-phosphate acyltransferase 2, mitochondrial.	Ig-like domain-containing protein.	0.472
LOC103478325	CNOT2	ENSPREP00000019375	ENSPREP00000008848	CKLF-like MARVEL transmembrane domain containing 8a.	CCR4-NOT transcription complex subunit 2.	0.473
LOC103478325	LOC103466190	ENSPREP00000019375	ENSPREP00000030729	CKLF-like MARVEL transmembrane domain containing 8a.	CCR4-NOT transcription complex, subunit 2.	0.473

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.564

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

5 of 13

2.93

5.3

1.41e-10

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

4 of 7

3.11

4.74

2.06e-09

GO:0019752

Carboxylic acid metabolic process

8 of 477

1.57

2.75

2.06e-09

GO:0045454

Cell redox homeostasis

3 of 20

2.53

2.65

1.03e-05

GO:0009063

Cellular amino acid catabolic process

3 of 42

2.2

2.15

6.41e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004148

Dihydrolipoyl dehydrogenase activity

3 of 6

3.05

2.81

7.67e-06

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 8

2.92

2.8

7.67e-06

GO:0016746

Acyltransferase activity

5 of 166

1.83

2.29

7.67e-06

GO:0003863

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

2 of 2

3.35

2.04

0.00021

GO:0016491

Oxidoreductase activity

6 of 680

1.29

1.4

5.20e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

10 of 45

2.7

11.15

9.60e-24

GO:0045240

Dihydrolipoyl dehydrogenase complex

6 of 12

3.05

7.52

9.24e-15

GO:0045254

Pyruvate dehydrogenase complex

4 of 5

3.25

5.34

1.81e-10

GO:0005759

Mitochondrial matrix

6 of 76

2.25

4.87

3.83e-11

GO:0045252

Oxoglutarate dehydrogenase complex

4 of 10

2.95

4.8

1.30e-09

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23006831

(2012) Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation.

3 of 3

3.35

2.98

4.18e-06

PMID:34702846

(2021) MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes.

3 of 4

3.22

2.97

4.18e-06

PMID:30619403

(2018) Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana.

3 of 5

3.13

2.96

4.18e-06

PMID:31266864

(2019) DayNight Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolae.

3 of 8

2.92

2.77

8.61e-06

PMID:33413098

(2021) Nutrient-imbalanced conditions shift the interplay between zooplankton and gut microbiota.

3 of 9

2.87

2.75

9.18e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14150

Dihydrolipoyl dehydrogenase complex, and acetyl-CoA biosynthetic process from pyruvate

11 of 19

3.11

15.36

2.61e-30

CL:14153

Citrate cycle (TCA cycle)

8 of 12

3.17

11.04

2.13e-21

CL:14155

acetyl-CoA biosynthetic process from pyruvate, and Dihydrolipoyl dehydrogenase activity

5 of 6

3.27

6.6

8.43e-13

CL:14167

Thiamine pyrophosphate binding, and Succinyltransferase activity

2 of 5

2.95

1.66

0.0010

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gtt00020

Citrate cycle (TCA cycle)

8 of 22

2.91

10.09

3.15e-20

gtt00620

Pyruvate metabolism

7 of 42

2.57

7.41

9.44e-16

gtt00640

Propanoate metabolism

6 of 21

2.8

7.37

6.87e-15

gtt00280

Valine, leucine and isoleucine degradation

6 of 26

2.71

7.05

1.84e-14

gtt00010

Glycolysis / Gluconeogenesis

7 of 55

2.45

6.94

3.00e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389661

Glyoxylate metabolism and glycine degradation

11 of 42

2.77

13.04

1.33e-27

MAP-70268

Pyruvate metabolism

7 of 26

2.78

8.0

2.81e-16

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

8 of 53

2.53

7.88

4.20e-17

MAP-71291

Metabolism of amino acids and derivatives

11 of 248

2.0

6.55

6.19e-20

MAP-70895

Branched-chain amino acid catabolism

6 of 28

2.68

6.44

2.90e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 37

2.63

7.06

9.50e-15

GOCC:0045254

Pyruvate dehydrogenase complex

4 of 7

3.11

4.66

2.90e-09

GOCC:0045240

Dihydrolipoyl dehydrogenase complex

3 of 6

3.05

3.26

1.13e-06

GOCC:0005947

Mitochondrial alpha-ketoglutarate dehydrogenase complex

2 of 2

3.35

2.2

0.00011

GOCC:0005759

Mitochondrial matrix

3 of 56

2.08

1.91

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

3 of 4

3.22

3.46

5.20e-07

KW-0012

Acyltransferase

3 of 35

2.28

2.27

4.15e-05

KW-0560

Oxidoreductase

4 of 136

1.82

2.03

3.60e-05

KW-0786

Thiamine pyrophosphate

2 of 5

2.95

2.03

0.00021

KW-0676

Redox-active center

2 of 20

2.35

1.46

0.0019

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

5 of 5

3.35

6.4

2.19e-12

PF02817

e3 binding domain

3 of 3

3.35

3.34

9.36e-07

PF00364

Biotin-requiring enzyme

3 of 9

2.87

2.82

6.86e-06

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 14

2.68

2.59

1.59e-05

PF02780

Transketolase, C-terminal domain

2 of 7

2.8

1.51

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001078

2-oxoacid dehydrogenase acyltransferase, catalytic domain

5 of 5

3.35

6.17

5.90e-12

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

5 of 15

2.87

5.21

1.81e-10

IPR036625

E3-binding domain superfamily

3 of 3

3.35

3.19

1.69e-06

IPR004167

Peripheral subunit-binding domain

3 of 3

3.35

3.19

1.69e-06

IPR045257

Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component

3 of 4

3.22

3.17

1.77e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 8

2.75

1.39

0.0030

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