STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSPREP00000021820HtrA serine peptidase 4. (196 aa)    
Predicted Functional Partners:
scp2
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
    
 0.947
LOC103464006
Sterol carrier protein 2b.
    
 0.947
Katnal2
Katanin p60 subunit A-like 2.
   
 0.754
Birc6
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
 0.727
psmd1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
    
 0.726
ephx2
Epoxide hydrolase 2, cytoplasmic.
  
 
 0.711
psmc6
Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.
   
 0.695
psmc3
Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.
   
 0.695
psmc4
Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.
   
 0.695
psmd12
Proteasome 26S subunit, non-ATPase 12.
    
 0.679
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.