LOC103480961 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103480961

Sphingomyelin synthase 2b. (377 aa)

Predicted Functional Partners:

smpd1

0.941

smpd2

0.939

acer1

0.932

LOC103482088

0.928

asah1

0.927

smpd4

0.927

ugcg

0.926

smpd3

0.924

degs1

0.924

degs2

0.924

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103480961	LOC103482088	ENSPREP00000021984	ENSPREP00000024304	Sphingomyelin synthase 2b.	Neutral ceramidase.	0.928
LOC103480961	acer1	ENSPREP00000021984	ENSPREP00000012822	Sphingomyelin synthase 2b.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.932
LOC103480961	asah1	ENSPREP00000021984	ENSPREP00000000094	Sphingomyelin synthase 2b.	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	0.927
LOC103480961	degs1	ENSPREP00000021984	ENSPREP00000011671	Sphingomyelin synthase 2b.	Delta(4)-desaturase, sphingolipid 1.	0.924
LOC103480961	degs2	ENSPREP00000021984	ENSPREP00000024055	Sphingomyelin synthase 2b.	Delta(4)-desaturase, sphingolipid 2.	0.924
LOC103480961	smpd1	ENSPREP00000021984	ENSPREP00000021479	Sphingomyelin synthase 2b.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.941
LOC103480961	smpd2	ENSPREP00000021984	ENSPREP00000018006	Sphingomyelin synthase 2b.	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase).	0.939
LOC103480961	smpd3	ENSPREP00000021984	ENSPREP00000003958	Sphingomyelin synthase 2b.	Sphingomyelin phosphodiesterase 3, neutral.	0.924
LOC103480961	smpd4	ENSPREP00000021984	ENSPREP00000031033	Sphingomyelin synthase 2b.	Sphingomyelin phosphodiesterase 4.	0.927
LOC103480961	ugcg	ENSPREP00000021984	ENSPREP00000025543	Sphingomyelin synthase 2b.	UDP-glucose ceramide glucosyltransferase.	0.926
LOC103482088	LOC103480961	ENSPREP00000024304	ENSPREP00000021984	Neutral ceramidase.	Sphingomyelin synthase 2b.	0.928
LOC103482088	acer1	ENSPREP00000024304	ENSPREP00000012822	Neutral ceramidase.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.954
LOC103482088	asah1	ENSPREP00000024304	ENSPREP00000000094	Neutral ceramidase.	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	0.952
LOC103482088	degs1	ENSPREP00000024304	ENSPREP00000011671	Neutral ceramidase.	Delta(4)-desaturase, sphingolipid 1.	0.927
LOC103482088	degs2	ENSPREP00000024304	ENSPREP00000024055	Neutral ceramidase.	Delta(4)-desaturase, sphingolipid 2.	0.927
LOC103482088	smpd1	ENSPREP00000024304	ENSPREP00000021479	Neutral ceramidase.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.765
LOC103482088	smpd2	ENSPREP00000024304	ENSPREP00000018006	Neutral ceramidase.	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase).	0.835
LOC103482088	smpd3	ENSPREP00000024304	ENSPREP00000003958	Neutral ceramidase.	Sphingomyelin phosphodiesterase 3, neutral.	0.717
LOC103482088	smpd4	ENSPREP00000024304	ENSPREP00000031033	Neutral ceramidase.	Sphingomyelin phosphodiesterase 4.	0.745
LOC103482088	ugcg	ENSPREP00000024304	ENSPREP00000025543	Neutral ceramidase.	UDP-glucose ceramide glucosyltransferase.	0.944

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

21

PPI enrichment p-value:

2.12e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 114

1.93

3.7

1.29e-09

GO:0000387

Spliceosomal snRNP assembly

4 of 13

2.63

3.67

1.22e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 570

1.29

1.69

7.21e-07

GO:0017069

snRNA binding

2 of 10

2.45

1.03

0.0129

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005685

U1 snRNP

6 of 9

2.97

7.13

4.16e-14

GO:0005686

U2 snRNP

6 of 18

2.67

6.38

3.72e-13

GO:0071011

Precatalytic spliceosome

6 of 20

2.62

6.24

5.45e-13

GO:0097525

Spliceosomal snRNP complex

7 of 41

2.38

6.11

1.32e-13

GO:0005682

U5 snRNP

5 of 10

2.84

5.76

1.42e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8704

U2 snRNP, and snRNA binding

8 of 19

2.77

8.8

5.04e-18

CL:8701

Small nuclear ribonucleoprotein complex, and snRNA binding

9 of 35

2.55

8.7

6.73e-19

CL:8706

U1 snRNP, and KH domain

6 of 10

2.92

7.1

4.17e-14

CL:8709

SLBP independent Processing of Histone Pre-mRNAs

4 of 5

3.05

4.63

3.12e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

9 of 158

1.9

4.93

1.25e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

5 of 6

3.07

6.0

8.13e-12

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

5 of 7

3.0

5.92

1.04e-11

MAP-75067

Processing of Capped Intronless Pre-mRNA

5 of 22

2.5

4.67

7.06e-10

MAP-72172

mRNA Splicing

9 of 177

1.85

4.47

2.02e-13

MAP-73856

RNA Polymerase II Transcription Termination

5 of 50

2.14

3.62

2.26e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097525

Spliceosomal snRNP complex

6 of 26

2.51

5.52

9.83e-12

GOCC:0005689

U12-type spliceosomal complex

5 of 11

2.8

5.46

4.87e-11

GOCC:0005682

U5 snRNP

5 of 11

2.8

5.46

4.87e-11

GOCC:0005687

U4 snRNP

4 of 7

2.9

4.45

5.77e-09

GOCC:1990904

Ribonucleoprotein complex

9 of 258

1.69

3.57

5.83e-12

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

6 of 16

2.72

6.41

4.24e-13

KW-0687

Ribonucleoprotein

6 of 75

2.05

4.05

6.04e-10

KW-0747

Spliceosome

3 of 10

2.62

2.92

3.50e-06

KW-0539

Nucleus

6 of 297

1.45

1.95

1.34e-06

KW-0694

RNA-binding

4 of 140

1.6

1.7

8.71e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047575

Sm domain

6 of 17

2.69

5.75

8.59e-12

IPR001163

Sm domain, eukaryotic/archaea-type

6 of 17

2.69

5.75

8.59e-12

IPR010920

LSM domain superfamily

6 of 21

2.6

5.66

8.59e-12

IPR034099

Small nuclear ribonucleoprotein Sm D3

2 of 2

3.14

1.45

0.0024

IPR027141

Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3

2 of 3

2.97

1.39

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

6 of 17

2.69

6.22

8.97e-13

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