mrps34 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

mrps34

Mitochondrial ribosomal protein S34. (219 aa)

Predicted Functional Partners:

mrps22

0.941

mrps16

0.935

mrps12

0.924

ENSPREP00000006860

0.922

mrps7

0.917

mrps15

0.913

mrps26

0.908

mrps11

0.905

Mrps6

0.905

mrps9

0.904

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006860	Mrps6	ENSPREP00000006860	ENSPREP00000034244	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S6.	0.999
ENSPREP00000006860	mrps11	ENSPREP00000006860	ENSPREP00000006904	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.	0.999
ENSPREP00000006860	mrps12	ENSPREP00000006860	ENSPREP00000020866	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.999
ENSPREP00000006860	mrps15	ENSPREP00000006860	ENSPREP00000008179	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family.	0.999
ENSPREP00000006860	mrps16	ENSPREP00000006860	ENSPREP00000008484	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S16.	0.999
ENSPREP00000006860	mrps22	ENSPREP00000006860	ENSPREP00000016358	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S22.	0.995
ENSPREP00000006860	mrps26	ENSPREP00000006860	ENSPREP00000010523	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S26.	0.994
ENSPREP00000006860	mrps34	ENSPREP00000006860	ENSPREP00000022414	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S34.	0.922
ENSPREP00000006860	mrps7	ENSPREP00000006860	ENSPREP00000003196	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S7.	0.998
ENSPREP00000006860	mrps9	ENSPREP00000006860	ENSPREP00000024088	Mitochondrial ribosomal protein S10.	Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.999
Mrps6	ENSPREP00000006860	ENSPREP00000034244	ENSPREP00000006860	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S10.	0.999
Mrps6	mrps11	ENSPREP00000034244	ENSPREP00000006904	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.	0.999
Mrps6	mrps12	ENSPREP00000034244	ENSPREP00000020866	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.999
Mrps6	mrps15	ENSPREP00000034244	ENSPREP00000008179	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family.	0.999
Mrps6	mrps16	ENSPREP00000034244	ENSPREP00000008484	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S16.	0.999
Mrps6	mrps22	ENSPREP00000034244	ENSPREP00000016358	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S22.	0.989
Mrps6	mrps26	ENSPREP00000034244	ENSPREP00000010523	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S26.	0.990
Mrps6	mrps34	ENSPREP00000034244	ENSPREP00000022414	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S34.	0.905
Mrps6	mrps7	ENSPREP00000034244	ENSPREP00000003196	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S7.	0.998
Mrps6	mrps9	ENSPREP00000034244	ENSPREP00000024088	Mitochondrial ribosomal protein S6.	Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

0.132

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

7 of 96

1.41

1.81

2.98e-06

GO:0006281

DNA repair

5 of 43

1.61

1.75

6.67e-05

GO:0006310

DNA recombination

4 of 29

1.69

1.66

0.00019

GO:0006260

DNA replication

4 of 32

1.64

1.61

0.00021

GO:0071103

DNA conformation change

3 of 13

1.91

1.52

0.00087

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003697

Single-stranded DNA binding

3 of 6

2.25

1.73

0.00052

GO:0140097

Catalytic activity, acting on DNA

5 of 50

1.55

1.57

0.00015

GO:0003917

DNA topoisomerase type I (single strand cut, ATP-independent) activity

2 of 2

2.55

1.15

0.0080

GO:0003677

DNA binding

6 of 339

0.79

0.52

0.0155

GO:0003676

Nucleic acid binding

7 of 468

0.72

0.49

0.0122

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 21

1.7

1.13

0.0046

GO:0009295

Nucleoid

3 of 33

1.51

0.97

0.0079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:604

ATP-dependent activity, acting on DNA, and DNA/RNA polymerase superfamily

4 of 5

2.45

3.07

1.33e-06

CL:600

DNA replication, and SOS response

6 of 38

1.75

2.54

5.87e-07

CL:1721

Mixed, incl. Phasin, and Thioredoxin

2 of 6

2.07

0.81

0.0301

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka03440

Homologous recombination

4 of 18

1.89

2.14

2.76e-05

aka03030

DNA replication

3 of 15

1.85

1.52

0.00075

aka03430

Mismatch repair

2 of 12

1.77

0.83

0.0241

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009295

Nucleoid

3 of 15

1.85

1.22

0.0037

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

3 of 19

1.75

1.13

0.0051

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00436

Single-strand binding protein family

2 of 2

2.55

0.9

0.0226

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