ccdc93 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

ccdc93

Coiled-coil domain containing 93. (621 aa)

Predicted Functional Partners:

ccdc22

0.954

COMMD10

0.912

commd1

0.873

commd2

0.868

COMMD6

0.856

LOC103471028

0.851

vps35l

0.834

commd4

0.827

commd8

0.822

vps29

0.820

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COMMD10	COMMD6	ENSPREP00000020345	ENSPREP00000009124	COMM domain containing 10.	COMM domain containing 6.	0.942
COMMD10	LOC103471028	ENSPREP00000020345	ENSPREP00000005102	COMM domain containing 10.	COMM domain containing 5.	0.968
COMMD10	ccdc22	ENSPREP00000020345	ENSPREP00000013388	COMM domain containing 10.	Coiled-coil domain containing 22.	0.975
COMMD10	ccdc93	ENSPREP00000020345	ENSPREP00000022832	COMM domain containing 10.	Coiled-coil domain containing 93.	0.912
COMMD10	commd1	ENSPREP00000020345	ENSPREP00000030354	COMM domain containing 10.	Copper metabolism (Murr1) domain containing 1.	0.939
COMMD10	commd2	ENSPREP00000020345	ENSPREP00000030037	COMM domain containing 10.	COMM domain containing 2.	0.980
COMMD10	commd4	ENSPREP00000020345	ENSPREP00000014300	COMM domain containing 10.	COMM domain containing 4.	0.924
COMMD10	commd8	ENSPREP00000020345	ENSPREP00000016897	COMM domain containing 10.	COMM domain containing 8.	0.916
COMMD10	vps29	ENSPREP00000020345	ENSPREP00000008393	COMM domain containing 10.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.680
COMMD10	vps35l	ENSPREP00000020345	ENSPREP00000031295	COMM domain containing 10.	VPS35 endosomal protein sorting factor like.	0.625
COMMD6	COMMD10	ENSPREP00000009124	ENSPREP00000020345	COMM domain containing 6.	COMM domain containing 10.	0.942
COMMD6	LOC103471028	ENSPREP00000009124	ENSPREP00000005102	COMM domain containing 6.	COMM domain containing 5.	0.846
COMMD6	ccdc22	ENSPREP00000009124	ENSPREP00000013388	COMM domain containing 6.	Coiled-coil domain containing 22.	0.937
COMMD6	ccdc93	ENSPREP00000009124	ENSPREP00000022832	COMM domain containing 6.	Coiled-coil domain containing 93.	0.856
COMMD6	commd1	ENSPREP00000009124	ENSPREP00000030354	COMM domain containing 6.	Copper metabolism (Murr1) domain containing 1.	0.964
COMMD6	commd2	ENSPREP00000009124	ENSPREP00000030037	COMM domain containing 6.	COMM domain containing 2.	0.942
COMMD6	commd4	ENSPREP00000009124	ENSPREP00000014300	COMM domain containing 6.	COMM domain containing 4.	0.910
COMMD6	commd8	ENSPREP00000009124	ENSPREP00000016897	COMM domain containing 6.	COMM domain containing 8.	0.875
COMMD6	vps29	ENSPREP00000009124	ENSPREP00000008393	COMM domain containing 6.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.712
COMMD6	vps35l	ENSPREP00000009124	ENSPREP00000031295	COMM domain containing 6.	VPS35 endosomal protein sorting factor like.	0.841

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.873

expected number of edges:

11

PPI enrichment p-value:

0.00201

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051028

mRNA transport

4 of 90

1.97

1.8

0.00023

GO:0006913

Nucleocytoplasmic transport

5 of 187

1.74

1.75

0.00014

GO:0006606

Protein import into nucleus

3 of 84

1.87

1.08

0.0077

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005643

Nuclear pore

5 of 52

2.3

3.65

4.62e-08

GO:0044614

Nuclear pore cytoplasmic filaments

2 of 4

3.02

1.6

0.0013

GO:0031965

Nuclear membrane

3 of 185

1.53

0.86

0.0153

GO:0031012

Extracellular matrix

4 of 489

1.23

0.75

0.0153

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:29440

VWF/SSPO/Zonadhesin-like, cysteine-rich domain

4 of 16

2.72

3.31

6.99e-07

CL:10273

Nuclear Pore Complex (NPC) Disassembly

4 of 35

2.38

3.11

9.14e-07

CL:10265

Nuclear pore, and Nucleocytoplasmic carrier activity

5 of 70

2.17

3.02

6.99e-07

CL:10278

Nuclear Pore Complex (NPC) Disassembly

3 of 25

2.4

2.26

5.39e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03013

RNA transport

4 of 136

1.79

1.89

7.13e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

5 of 76

2.14

3.11

3.72e-07

MAP-72202

Transport of Mature Transcript to Cytoplasm

5 of 82

2.1

3.08

3.72e-07

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 38

2.34

2.95

1.78e-06

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 39

2.33

2.95

1.78e-06

MAP-159230

Transport of the SLBP Dependant Mature mRNA

4 of 39

2.33

2.95

1.78e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070701

Mucus layer

3 of 10

2.79

2.58

1.81e-05

GOCC:0005643

Nuclear pore

4 of 51

2.21

2.46

1.49e-05

GOCC:0012505

Endomembrane system

6 of 2029

0.79

0.45

0.0392

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014853

VWF/SSPO/Zonadhesin-like, cysteine-rich domain

4 of 26

2.5

2.78

5.60e-06

IPR001846

Von Willebrand factor, type D domain

4 of 37

2.35

2.59

1.03e-05

IPR045255

Ran binding protein RanBP1-like

2 of 4

3.02

1.18

0.0075

IPR000156

Ran binding domain

2 of 4

3.02

1.18

0.0075

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00832

This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.

4 of 26

2.5

3.26

6.13e-07

SM00160

Ran-binding domain

2 of 4

3.02

1.62

0.0012

SM00216

Von Willebrand factor (vWF) type D domain

2 of 24

2.24

0.95

0.0176

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