gcn1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

gcn1

GCN1 activator of EIF2AK4. (2690 aa)

Predicted Functional Partners:

drg2

0.945

Abcf3

0.941

ABCF3

0.941

LOC103481251

0.939

RPL19

0.938

rps15

0.925

rps13

0.921

rps9

0.916

mrps5

0.909

rack1

0.905

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCF3	Abcf3	ENSPREP00000032315	ENSPREP00000032290	ATP binding cassette subfamily F member 3.	ATP-binding cassette, sub-family F (GCN20), member 3.	0.900
ABCF3	drg2	ENSPREP00000032315	ENSPREP00000029433	ATP binding cassette subfamily F member 3.	Developmentally regulated GTP binding protein 2.	0.482
ABCF3	gcn1	ENSPREP00000032315	ENSPREP00000022982	ATP binding cassette subfamily F member 3.	GCN1 activator of EIF2AK4.	0.941
ABCF3	mrps5	ENSPREP00000032315	ENSPREP00000002339	ATP binding cassette subfamily F member 3.	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	0.794
ABCF3	rack1	ENSPREP00000032315	ENSPREP00000005808	ATP binding cassette subfamily F member 3.	Receptor for activated C kinase 1.	0.413
ABCF3	rps13	ENSPREP00000032315	ENSPREP00000006834	ATP binding cassette subfamily F member 3.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.646
ABCF3	rps15	ENSPREP00000032315	ENSPREP00000013069	ATP binding cassette subfamily F member 3.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.784
ABCF3	rps9	ENSPREP00000032315	ENSPREP00000011631	ATP binding cassette subfamily F member 3.	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.695
Abcf3	ABCF3	ENSPREP00000032290	ENSPREP00000032315	ATP-binding cassette, sub-family F (GCN20), member 3.	ATP binding cassette subfamily F member 3.	0.900
Abcf3	drg2	ENSPREP00000032290	ENSPREP00000029433	ATP-binding cassette, sub-family F (GCN20), member 3.	Developmentally regulated GTP binding protein 2.	0.482
Abcf3	gcn1	ENSPREP00000032290	ENSPREP00000022982	ATP-binding cassette, sub-family F (GCN20), member 3.	GCN1 activator of EIF2AK4.	0.941
Abcf3	mrps5	ENSPREP00000032290	ENSPREP00000002339	ATP-binding cassette, sub-family F (GCN20), member 3.	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	0.794
Abcf3	rack1	ENSPREP00000032290	ENSPREP00000005808	ATP-binding cassette, sub-family F (GCN20), member 3.	Receptor for activated C kinase 1.	0.413
Abcf3	rps13	ENSPREP00000032290	ENSPREP00000006834	ATP-binding cassette, sub-family F (GCN20), member 3.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.646
Abcf3	rps15	ENSPREP00000032290	ENSPREP00000013069	ATP-binding cassette, sub-family F (GCN20), member 3.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.784
Abcf3	rps9	ENSPREP00000032290	ENSPREP00000011631	ATP-binding cassette, sub-family F (GCN20), member 3.	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.695
LOC103481251	RPL19	ENSPREP00000032545	ENSPREP00000012744	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.900
LOC103481251	drg2	ENSPREP00000032545	ENSPREP00000029433	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Developmentally regulated GTP binding protein 2.	0.494
LOC103481251	gcn1	ENSPREP00000032545	ENSPREP00000022982	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	GCN1 activator of EIF2AK4.	0.939
LOC103481251	mrps5	ENSPREP00000032545	ENSPREP00000002339	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	0.991

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070989

Oxidative demethylation

3 of 12

2.72

1.92

0.00030

GO:0006357

Regulation of transcription by RNA polymerase II

7 of 2320

0.8

0.47

0.0296

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003712

Transcription coregulator activity

8 of 414

1.6

2.76

5.31e-09

GO:0070330

Aromatase activity

3 of 8

2.89

2.59

1.83e-05

GO:0020037

Heme binding

3 of 157

1.6

0.8

0.0238

GO:0005506

Iron ion binding

3 of 171

1.56

0.78

0.0248

GO:0003713

Transcription coactivator activity

3 of 198

1.5

0.73

0.0312

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016592

Mediator complex

8 of 40

2.62

8.09

4.21e-17

GO:0070847

Core mediator complex

4 of 10

2.92

4.19

1.82e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10912

Mediator complex, and Atorvastatin ADME

11 of 44

2.72

12.29

2.68e-26

CL:10931

Mediator complex

8 of 19

2.94

9.94

8.22e-20

CL:10934

Mediator complex

6 of 14

2.95

7.22

2.64e-14

CL:10937

Core mediator complex, and Mediator complex, subunit Med7/Med21-like

5 of 7

3.17

6.37

1.95e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9754706

Atorvastatin ADME

3 of 13

2.68

2.39

3.84e-05

MAP-9757110

Prednisone ADME

3 of 22

2.45

2.19

7.87e-05

MAP-9027307

Biosynthesis of maresin-like SPMs

3 of 23

2.43

2.18

7.87e-05

MAP-5423646

Aflatoxin activation and detoxification

3 of 25

2.4

2.17

7.87e-05

MAP-211958

Miscellaneous substrates

3 of 25

2.4

2.17

7.87e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016592

Mediator complex

3 of 23

2.43

1.86

0.00033

GOCC:0098827

Endoplasmic reticulum subcompartment

3 of 179

1.54

0.82

0.0199

GOCC:0043231

Intracellular membrane-bounded organelle

11 of 6354

0.56

0.46

0.00059

GOCC:0005634

Nucleus

8 of 3523

0.67

0.46

0.0130

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

6 of 52

2.38

5.13

3.12e-11

KW-0805

Transcription regulation

6 of 356

1.54

2.14

1.09e-06

KW-0539

Nucleus

6 of 1189

1.02

0.89

0.00062

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 68

1.96

1.03

0.0106

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.32

1.14

0.0090

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.32

1.14

0.0090

IPR036396

Cytochrome P450 superfamily

3 of 68

1.96

1.02

0.0110

IPR001128

Cytochrome P450

3 of 68

1.96

1.02

0.0110

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