pnisr protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pnisr

Uncharacterized protein. (832 aa)

Predicted Functional Partners:

luc7l3

0.936

pnn

0.904

LOC103471424

0.799

actl6a

0.781

mysm1

0.777

ttc14

0.751

ZFC3H1

0.738

prpf39

0.728

LOC103469839

0.706

LOC103474056

0.706

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103469839	actl6a	ENSPREP00000005681	ENSPREP00000022295	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	Actin-like 6A; Belongs to the actin family.	0.978
LOC103469839	mysm1	ENSPREP00000005681	ENSPREP00000031373	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	Myb-like, SWIRM and MPN domains 1.	0.853
LOC103469839	pnisr	ENSPREP00000005681	ENSPREP00000023319	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	Uncharacterized protein.	0.706
LOC103471424	ZFC3H1	ENSPREP00000023381	ENSPREP00000025162	Si:ch211-114c17.1.	Zinc finger C3H1-type containing.	0.410
LOC103471424	luc7l3	ENSPREP00000023381	ENSPREP00000030774	Si:ch211-114c17.1.	Uncharacterized protein.	0.744
LOC103471424	pnisr	ENSPREP00000023381	ENSPREP00000023319	Si:ch211-114c17.1.	Uncharacterized protein.	0.799
LOC103471424	ttc14	ENSPREP00000023381	ENSPREP00000033560	Si:ch211-114c17.1.	Tetratricopeptide repeat domain 14.	0.453
LOC103474056	actl6a	ENSPREP00000009045	ENSPREP00000022295	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	Actin-like 6A; Belongs to the actin family.	0.978
LOC103474056	mysm1	ENSPREP00000009045	ENSPREP00000031373	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	Myb-like, SWIRM and MPN domains 1.	0.853
LOC103474056	pnisr	ENSPREP00000009045	ENSPREP00000023319	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	Uncharacterized protein.	0.706
ZFC3H1	LOC103471424	ENSPREP00000025162	ENSPREP00000023381	Zinc finger C3H1-type containing.	Si:ch211-114c17.1.	0.410
ZFC3H1	pnisr	ENSPREP00000025162	ENSPREP00000023319	Zinc finger C3H1-type containing.	Uncharacterized protein.	0.738
ZFC3H1	ttc14	ENSPREP00000025162	ENSPREP00000033560	Zinc finger C3H1-type containing.	Tetratricopeptide repeat domain 14.	0.595
actl6a	LOC103469839	ENSPREP00000022295	ENSPREP00000005681	Actin-like 6A; Belongs to the actin family.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	0.978
actl6a	LOC103474056	ENSPREP00000022295	ENSPREP00000009045	Actin-like 6A; Belongs to the actin family.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.	0.978
actl6a	mysm1	ENSPREP00000022295	ENSPREP00000031373	Actin-like 6A; Belongs to the actin family.	Myb-like, SWIRM and MPN domains 1.	0.925
actl6a	pnisr	ENSPREP00000022295	ENSPREP00000023319	Actin-like 6A; Belongs to the actin family.	Uncharacterized protein.	0.781
luc7l3	LOC103471424	ENSPREP00000030774	ENSPREP00000023381	Uncharacterized protein.	Si:ch211-114c17.1.	0.744
luc7l3	pnisr	ENSPREP00000030774	ENSPREP00000023319	Uncharacterized protein.	Uncharacterized protein.	0.936
luc7l3	pnn	ENSPREP00000030774	ENSPREP00000011254	Uncharacterized protein.	Pinin, desmosome associated protein.	0.828

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Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.531

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

4 of 146

1.62

0.85

0.0181

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019888

Protein phosphatase regulator activity

5 of 61

2.09

2.89

1.02e-06

GO:0030234

Enzyme regulator activity

6 of 929

0.99

0.67

0.0100

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005963

Magnesium-dependent protein serine/threonine phosphatase complex

5 of 21

2.56

4.37

3.78e-09

GO:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.84

6.22e-08

GO:0140535

Intracellular protein-containing complex

6 of 610

1.17

1.12

0.00026

GO:1902494

Catalytic complex

6 of 1194

0.88

0.6

0.0104

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17552

Protein phosphatase type 2A complex, and ERKs are inactivated

7 of 16

2.82

7.49

4.28e-15

CL:17555

Protein phosphatase type 2A complex, and Serine/Threonine protein phosphatase PP2A-like

5 of 10

2.88

5.46

6.04e-11

CL:17557

Protein phosphatase 2A regulatory subunit PR55, and Serine/Threonine protein phosphatase PP2A-like

2 of 5

2.78

1.38

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla04114

Oocyte meiosis

6 of 81

2.05

3.94

1.29e-09

apla03015

mRNA surveillance pathway

5 of 45

2.22

3.91

7.57e-09

apla04261

Adrenergic signaling in cardiomyocytes

5 of 81

1.97

3.17

8.21e-08

apla04350

TGF-beta signaling pathway

3 of 72

1.8

1.54

0.00059

apla04136

Autophagy - other

2 of 19

2.2

1.35

0.0028

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389513

CTLA4 inhibitory signaling

6 of 23

2.6

5.58

1.24e-11

MAP-196299

Beta-catenin phosphorylation cascade

5 of 12

2.8

5.15

2.07e-10

MAP-195253

Degradation of beta-catenin by the destruction complex

6 of 44

2.31

4.68

2.07e-10

MAP-388841

Costimulation by the CD28 family

6 of 72

2.1

3.99

1.66e-09

MAP-68882

Mitotic Anaphase

7 of 210

1.7

3.0

5.15e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000159

Protein phosphatase type 2A complex

4 of 12

2.7

3.68

1.27e-07

GOCC:0008287

Protein serine/threonine phosphatase complex

5 of 44

2.23

3.4

1.27e-07

GOCC:1902494

Catalytic complex

9 of 1192

1.06

1.23

9.68e-07

GOCC:0032991

Protein-containing complex

10 of 3780

0.6

0.48

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01603

Protein phosphatase 2A regulatory B subunit (B56 family)

3 of 4

3.05

2.66

1.47e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002554

Protein phosphatase 2A, regulatory B subunit, B56

3 of 4

3.05

2.39

4.57e-05

IPR047129

Serine/Threonine protein phosphatase PP2A-like

2 of 4

2.88

0.97

0.0176

IPR011989

Armadillo-like helical

4 of 192

1.5

0.83

0.0176

IPR006186

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

2 of 12

2.4

0.75

0.0438

IPR016024

Armadillo-type fold

4 of 280

1.33

0.65

0.0380

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00156

Protein phosphatase 2A homologues, catalytic domain.

2 of 11

2.44

0.9

0.0225

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