LOC103460381 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC103460381

Uncharacterized protein. (612 aa)

Predicted Functional Partners:

Katnal2

0.509

hook2

0.463

aktip

0.456

fcf1

0.405

hook1

0.403

HOOK3

0.403

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HOOK3	LOC103460381	ENSPREP00000010092	ENSPREP00000023758	Hook microtubule tethering protein 3.	Uncharacterized protein.	0.403
HOOK3	aktip	ENSPREP00000010092	ENSPREP00000009456	Hook microtubule tethering protein 3.	Akt interacting protein.	0.810
HOOK3	hook2	ENSPREP00000010092	ENSPREP00000021239	Hook microtubule tethering protein 3.	Hook microtubule-tethering protein 2.	0.473
Katnal2	LOC103460381	ENSPREP00000007118	ENSPREP00000023758	Katanin p60 subunit A-like 2.	Uncharacterized protein.	0.509
LOC103460381	HOOK3	ENSPREP00000023758	ENSPREP00000010092	Uncharacterized protein.	Hook microtubule tethering protein 3.	0.403
LOC103460381	Katnal2	ENSPREP00000023758	ENSPREP00000007118	Uncharacterized protein.	Katanin p60 subunit A-like 2.	0.509
LOC103460381	aktip	ENSPREP00000023758	ENSPREP00000009456	Uncharacterized protein.	Akt interacting protein.	0.456
LOC103460381	fcf1	ENSPREP00000023758	ENSPREP00000028423	Uncharacterized protein.	FCF1 rRNA-processing protein.	0.405
LOC103460381	hook1	ENSPREP00000023758	ENSPREP00000003890	Uncharacterized protein.	Hook microtubule-tethering protein 1.	0.403
LOC103460381	hook2	ENSPREP00000023758	ENSPREP00000021239	Uncharacterized protein.	Hook microtubule-tethering protein 2.	0.463
aktip	HOOK3	ENSPREP00000009456	ENSPREP00000010092	Akt interacting protein.	Hook microtubule tethering protein 3.	0.810
aktip	LOC103460381	ENSPREP00000009456	ENSPREP00000023758	Akt interacting protein.	Uncharacterized protein.	0.456
aktip	hook1	ENSPREP00000009456	ENSPREP00000003890	Akt interacting protein.	Hook microtubule-tethering protein 1.	0.810
aktip	hook2	ENSPREP00000009456	ENSPREP00000021239	Akt interacting protein.	Hook microtubule-tethering protein 2.	0.890
fcf1	LOC103460381	ENSPREP00000028423	ENSPREP00000023758	FCF1 rRNA-processing protein.	Uncharacterized protein.	0.405
hook1	LOC103460381	ENSPREP00000003890	ENSPREP00000023758	Hook microtubule-tethering protein 1.	Uncharacterized protein.	0.403
hook1	aktip	ENSPREP00000003890	ENSPREP00000009456	Hook microtubule-tethering protein 1.	Akt interacting protein.	0.810
hook1	hook2	ENSPREP00000003890	ENSPREP00000021239	Hook microtubule-tethering protein 1.	Hook microtubule-tethering protein 2.	0.475
hook2	HOOK3	ENSPREP00000021239	ENSPREP00000010092	Hook microtubule-tethering protein 2.	Hook microtubule tethering protein 3.	0.473
hook2	LOC103460381	ENSPREP00000021239	ENSPREP00000023758	Hook microtubule-tethering protein 2.	Uncharacterized protein.	0.463

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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