LOC103466413 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

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[Homology]

Score

LOC103466413

Tyrosine-protein kinase. (449 aa)

Predicted Functional Partners:

pag1

0.898

LOC108165961

0.779

LOC103467856

0.691

SRC

0.690

LOC103463567

0.686

lck

0.678

esr1

0.675

LOC103479892

0.655

shc1

0.651

SHC3

0.651

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103463567	LOC103466413	ENSPREP00000016488	ENSPREP00000023780	Leupaxin.	Tyrosine-protein kinase.	0.686
LOC103463567	LOC103467856	ENSPREP00000016488	ENSPREP00000031006	Leupaxin.	Tyrosine-protein kinase.	0.491
LOC103463567	LOC103479892	ENSPREP00000016488	ENSPREP00000022831	Leupaxin.	Tyrosine-protein kinase.	0.491
LOC103463567	SRC	ENSPREP00000016488	ENSPREP00000016288	Leupaxin.	Tyrosine-protein kinase.	0.491
LOC103463567	lck	ENSPREP00000016488	ENSPREP00000003459	Leupaxin.	Tyrosine-protein kinase.	0.576
LOC103463567	pag1	ENSPREP00000016488	ENSPREP00000011895	Leupaxin.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.513
LOC103466413	LOC103463567	ENSPREP00000023780	ENSPREP00000016488	Tyrosine-protein kinase.	Leupaxin.	0.686
LOC103466413	LOC103467856	ENSPREP00000023780	ENSPREP00000031006	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.691
LOC103466413	LOC103479892	ENSPREP00000023780	ENSPREP00000022831	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.655
LOC103466413	LOC108165961	ENSPREP00000023780	ENSPREP00000024919	Tyrosine-protein kinase.	F-BAR domain-containing protein.	0.779
LOC103466413	SHC3	ENSPREP00000023780	ENSPREP00000025465	Tyrosine-protein kinase.	SHC adaptor protein 3.	0.651
LOC103466413	SRC	ENSPREP00000023780	ENSPREP00000016288	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.690
LOC103466413	esr1	ENSPREP00000023780	ENSPREP00000006015	Tyrosine-protein kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.675
LOC103466413	lck	ENSPREP00000023780	ENSPREP00000003459	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.678
LOC103466413	pag1	ENSPREP00000023780	ENSPREP00000011895	Tyrosine-protein kinase.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.898
LOC103466413	shc1	ENSPREP00000023780	ENSPREP00000025346	Tyrosine-protein kinase.	SHC (Src homology 2 domain containing) transforming protein 1.	0.651
LOC103467856	LOC103463567	ENSPREP00000031006	ENSPREP00000016488	Tyrosine-protein kinase.	Leupaxin.	0.491
LOC103467856	LOC103466413	ENSPREP00000031006	ENSPREP00000023780	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.691
LOC103467856	LOC108165961	ENSPREP00000031006	ENSPREP00000024919	Tyrosine-protein kinase.	F-BAR domain-containing protein.	0.564
LOC103467856	SHC3	ENSPREP00000031006	ENSPREP00000025465	Tyrosine-protein kinase.	SHC adaptor protein 3.	0.531

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.876

expected number of edges:

12

PPI enrichment p-value:

0.000499

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010608

Post-transcriptional regulation of gene expression

7 of 445

1.51

1.99

2.82e-06

GO:0006378

mRNA polyadenylation

3 of 21

2.47

1.92

0.00027

GO:0006417

Regulation of translation

6 of 377

1.52

1.72

3.71e-05

GO:0043489

RNA stabilization

3 of 44

2.15

1.59

0.00090

GO:0017148

Negative regulation of translation

4 of 139

1.78

1.55

0.00054

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1169

1.09

0.96

0.00069

GO:0004652

Polynucleotide adenylyltransferase activity

2 of 15

2.44

0.85

0.0281

GO:1901363

Heterocyclic compound binding

10 of 6300

0.52

0.34

0.0281

GO:0097159

Organic cyclic compound binding

10 of 6378

0.51

0.34

0.0281

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

3 of 15

2.62

2.3

5.53e-05

PMID:34263725

(2021) A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma.

2 of 21

2.3

0.9

0.0218

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2940

Mixed, incl. Deadenylation-dependent mRNA decay, and Anti-proliferative protein

5 of 90

2.06

2.7

2.52e-06

CL:11094

mRNA cleavage and polyadenylation specificity factor complex

2 of 7

2.77

0.95

0.0189

CL:3058

mRNA decay by 5 to 3 exoribonuclease, and Scd6-like Sm domain

2 of 15

2.44

0.79

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04914

Progesterone-mediated oocyte maturation

3 of 88

1.85

1.38

0.0016

pret04114

Oocyte meiosis

3 of 111

1.75

1.34

0.0016

pret03018

RNA degradation

2 of 69

1.78

0.8

0.0284

pret03015

mRNA surveillance pathway

2 of 76

1.74

0.79

0.0284

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8953854

Metabolism of RNA

7 of 895

1.21

1.26

6.94e-05

MAP-429914

Deadenylation-dependent mRNA decay

3 of 74

1.93

1.18

0.0049

MAP-6804114

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

2 of 13

2.5

1.05

0.0122

MAP-77595

Processing of Intronless Pre-mRNAs

2 of 21

2.3

0.9

0.0220

MAP-75067

Processing of Capped Intronless Pre-mRNA

2 of 24

2.24

0.89

0.0226

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