Plcb1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

Plcb1

Uncharacterized protein. (33 aa)

Predicted Functional Partners:

LOC103463549

0.958

LOC103470235

0.958

LOC103473464

0.946

LOC103473465

0.946

PRKCA

0.936

LOC103459892

0.936

PRKCB

0.929

LOC103462546

0.925

LOC103464538

0.925

LOC103465228

0.925

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103459892	Plcb1	ENSPREP00000004745	ENSPREP00000023822	Calcium/calmodulin-dependent protein kinase II alpha.	Uncharacterized protein.	0.936
LOC103462546	Plcb1	ENSPREP00000001914	ENSPREP00000023822	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b.	Uncharacterized protein.	0.925
LOC103463549	Plcb1	ENSPREP00000017763	ENSPREP00000023822	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).	Uncharacterized protein.	0.958
LOC103464538	Plcb1	ENSPREP00000005533	ENSPREP00000023822	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	Uncharacterized protein.	0.925
LOC103465228	Plcb1	ENSPREP00000014571	ENSPREP00000023822	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	Uncharacterized protein.	0.925
LOC103470235	Plcb1	ENSPREP00000029602	ENSPREP00000023822	Uncharacterized protein.	Uncharacterized protein.	0.958
LOC103473464	Plcb1	ENSPREP00000003922	ENSPREP00000023822	Guanine nucleotide binding protein (G protein), alpha 14.	Uncharacterized protein.	0.946
LOC103473465	Plcb1	ENSPREP00000003946	ENSPREP00000023822	G protein subunit alpha q.	Uncharacterized protein.	0.946
PRKCA	PRKCB	ENSPREP00000000304	ENSPREP00000028542	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.901
PRKCA	Plcb1	ENSPREP00000000304	ENSPREP00000023822	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Uncharacterized protein.	0.936
PRKCB	PRKCA	ENSPREP00000028542	ENSPREP00000000304	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.901
PRKCB	Plcb1	ENSPREP00000028542	ENSPREP00000023822	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Uncharacterized protein.	0.929
Plcb1	LOC103459892	ENSPREP00000023822	ENSPREP00000004745	Uncharacterized protein.	Calcium/calmodulin-dependent protein kinase II alpha.	0.936
Plcb1	LOC103462546	ENSPREP00000023822	ENSPREP00000001914	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b.	0.925
Plcb1	LOC103463549	ENSPREP00000023822	ENSPREP00000017763	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).	0.958
Plcb1	LOC103464538	ENSPREP00000023822	ENSPREP00000005533	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.925
Plcb1	LOC103465228	ENSPREP00000023822	ENSPREP00000014571	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.925
Plcb1	LOC103470235	ENSPREP00000023822	ENSPREP00000029602	Uncharacterized protein.	Uncharacterized protein.	0.958
Plcb1	LOC103473464	ENSPREP00000023822	ENSPREP00000003922	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha 14.	0.946
Plcb1	LOC103473465	ENSPREP00000023822	ENSPREP00000003946	Uncharacterized protein.	G protein subunit alpha q.	0.946

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.714

expected number of edges:

25

PPI enrichment p-value:

0.0932

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

10 of 335

1.79

4.36

4.73e-14

GO:0006397

mRNA processing

10 of 420

1.69

3.84

2.19e-13

GO:0000398

mRNA splicing, via spliceosome

7 of 217

1.83

3.34

3.40e-09

GO:0051028

mRNA transport

4 of 90

1.97

2.11

4.38e-05

GO:0010467

Gene expression

11 of 1665

1.14

1.61

5.16e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1169

1.29

2.14

1.77e-11

GO:0003729

mRNA binding

4 of 282

1.47

1.06

0.0040

GO:0000339

RNA cap binding

2 of 16

2.41

1.01

0.0143

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 2

3.32

1.55

0.0016

GO:0016607

Nuclear speck

4 of 269

1.49

1.18

0.0019

GO:0002102

Podosome

2 of 18

2.36

1.16

0.0072

GO:0016604

Nuclear body

5 of 483

1.33

1.09

0.0016

GO:0005681

Spliceosomal complex

3 of 167

1.57

0.97

0.0089

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37941135

(2023) Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection.

2 of 15

2.44

0.89

0.0234

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2649

RNA Polymerase II Transcription Termination, and mRNA Splicing - Major Pathway

11 of 130

2.25

8.36

1.64e-21

CL:2657

RNA recognition motif domain

8 of 71

2.37

6.63

5.76e-15

CL:2737

mRNA 3-end processing

4 of 22

2.58

3.37

4.30e-07

CL:2739

Mixed, incl. SRSF7, RNA recognition motif, and SRSF1, RNA recognition motif 1

3 of 13

2.68

2.46

2.89e-05

CL:2665

Mixed, incl. ROK, N-terminal, and TAF15/EWS/TLS family

3 of 13

2.68

2.46

2.89e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03040

Spliceosome

9 of 120

2.19

6.81

3.94e-17

pret03015

mRNA surveillance pathway

3 of 76

1.91

1.63

0.00050

pret05168

Herpes simplex virus 1 infection

4 of 268

1.49

1.37

0.00050

pret03013

RNA transport

3 of 136

1.66

1.31

0.0015

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 251

1.96

6.14

6.02e-19

MAP-72172

mRNA Splicing

11 of 272

1.92

5.93

7.14e-19

MAP-73856

RNA Polymerase II Transcription Termination

7 of 78

2.27

5.56

8.26e-13

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 362

1.8

5.04

1.04e-17

MAP-72187

mRNA 3-end processing

6 of 67

2.27

4.73

1.08e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 79

2.02

2.03

8.00e-05

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.14

1.64

0.0011

GOCC:0002102

Podosome

2 of 25

2.22

0.89

0.0225

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

8 of 325

1.71

3.4

9.87e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

8 of 233

1.85

3.77

1.54e-10

IPR035979

RNA-binding domain superfamily

8 of 257

1.81

3.65

1.66e-10

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

8 of 264

1.8

3.62

1.66e-10

IPR012987

ROK, N-terminal

2 of 2

3.32

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

8 of 227

1.86

4.08

1.38e-11

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