ENSPREP00000023888 protein (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

ENSPREP00000023888

Uncharacterized protein. (220 aa)

Predicted Functional Partners:

cul1

0.958

skp1

0.951

Fbxl17

0.900

rbx1

0.781

LOC103479391

0.697

LOC103474461

0.697

bach2

0.610

ENSPREP00000018353

0.610

bach1

0.610

BACH1

0.610

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BACH1	ENSPREP00000023888	ENSPREP00000020334	ENSPREP00000023888	BTB domain and CNC homolog 1.	Uncharacterized protein.	0.610
BACH1	Fbxl17	ENSPREP00000020334	ENSPREP00000023856	BTB domain and CNC homolog 1.	F-box domain-containing protein.	0.610
BACH1	LOC103474461	ENSPREP00000020334	ENSPREP00000027846	BTB domain and CNC homolog 1.	Cullin 3; Belongs to the cullin family.	0.433
BACH1	LOC103479391	ENSPREP00000020334	ENSPREP00000024968	BTB domain and CNC homolog 1.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.433
BACH1	cul1	ENSPREP00000020334	ENSPREP00000016001	BTB domain and CNC homolog 1.	Cullin 1b; Belongs to the cullin family.	0.504
BACH1	rbx1	ENSPREP00000020334	ENSPREP00000026459	BTB domain and CNC homolog 1.	Ring-box 1, E3 ubiquitin protein ligase.	0.510
BACH1	skp1	ENSPREP00000020334	ENSPREP00000007574	BTB domain and CNC homolog 1.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.471
ENSPREP00000018353	ENSPREP00000023888	ENSPREP00000018353	ENSPREP00000023888	BTB domain-containing protein.	Uncharacterized protein.	0.610
ENSPREP00000018353	Fbxl17	ENSPREP00000018353	ENSPREP00000023856	BTB domain-containing protein.	F-box domain-containing protein.	0.610
ENSPREP00000018353	LOC103474461	ENSPREP00000018353	ENSPREP00000027846	BTB domain-containing protein.	Cullin 3; Belongs to the cullin family.	0.433
ENSPREP00000018353	LOC103479391	ENSPREP00000018353	ENSPREP00000024968	BTB domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.433
ENSPREP00000018353	cul1	ENSPREP00000018353	ENSPREP00000016001	BTB domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.504
ENSPREP00000018353	rbx1	ENSPREP00000018353	ENSPREP00000026459	BTB domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.510
ENSPREP00000018353	skp1	ENSPREP00000018353	ENSPREP00000007574	BTB domain-containing protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.471
ENSPREP00000023888	BACH1	ENSPREP00000023888	ENSPREP00000020334	Uncharacterized protein.	BTB domain and CNC homolog 1.	0.610
ENSPREP00000023888	ENSPREP00000018353	ENSPREP00000023888	ENSPREP00000018353	Uncharacterized protein.	BTB domain-containing protein.	0.610
ENSPREP00000023888	Fbxl17	ENSPREP00000023888	ENSPREP00000023856	Uncharacterized protein.	F-box domain-containing protein.	0.900
ENSPREP00000023888	LOC103474461	ENSPREP00000023888	ENSPREP00000027846	Uncharacterized protein.	Cullin 3; Belongs to the cullin family.	0.697
ENSPREP00000023888	LOC103479391	ENSPREP00000023888	ENSPREP00000024968	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.697
ENSPREP00000023888	bach1	ENSPREP00000023888	ENSPREP00000019106	Uncharacterized protein.	Uncharacterized protein.	0.610

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008333

Endosome to lysosome transport

7 of 57

2.41

5.83

8.48e-13

GO:0007034

Vacuolar transport

9 of 145

2.11

5.76

9.93e-15

GO:0034058

Endosomal vesicle fusion

5 of 10

3.02

5.6

4.31e-11

GO:0048284

Organelle fusion

8 of 112

2.17

5.47

3.00e-13

GO:0006906

Vesicle fusion

6 of 86

2.16

4.07

1.89e-09

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030897

HOPS complex

6 of 8

3.19

7.78

4.39e-15

GO:0099023

Vesicle tethering complex

8 of 60

2.44

7.14

8.23e-16

GO:0033263

CORVET complex

5 of 6

3.24

6.54

1.03e-12

GO:0005770

Late endosome

9 of 221

1.93

5.02

1.54e-14

GO:0031902

Late endosome membrane

7 of 123

2.07

4.69

1.11e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14867

Mixed, incl. CORVET complex, and Rab9

10 of 19

3.04

12.98

1.02e-25

CL:14869

CORVET complex, and Vacuolar HOPS complex

9 of 11

3.23

12.54

3.27e-24

CL:14873

HOPS complex

6 of 6

3.32

8.04

1.79e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret05132

Salmonella infection

6 of 240

1.72

2.7

1.07e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

6 of 100

2.1

3.76

6.48e-09

MAP-1643685

Disease

6 of 185

1.83

2.89

1.16e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0099023

Vesicle tethering complex

7 of 63

2.36

5.74

9.26e-13

GOCC:0030897

HOPS complex

4 of 5

3.22

4.7

2.79e-09

GOCC:0033263

CORVET complex

3 of 4

3.19

3.21

1.48e-06

GOCC:0005768

Endosome

5 of 327

1.5

1.58

0.00010

GOCC:0005776

Autophagosome

2 of 56

1.87

0.72

0.0437

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0967

Endosome

3 of 8

2.89

2.92

4.55e-06

KW-0458

Lysosome

3 of 14

2.65

2.71

9.37e-06

KW-0653

Protein transport

3 of 115

1.73

1.26

0.0024

KW-0968

Cytoplasmic vesicle

2 of 25

2.22

1.18

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00637

Region in Clathrin and VPS

3 of 3

3.32

3.0

3.76e-06

PF10367

Vacuolar sorting protein 39 domain 2

2 of 2

3.32

1.59

0.0014

PF10366

Vacuolar sorting protein 39 domain 1

2 of 2

3.32

1.59

0.0014

PF00780

CNH domain

2 of 6

2.84

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000547

Clathrin, heavy chain/VPS, 7-fold repeat

5 of 8

3.11

5.49

8.09e-11

IPR036322

WD40-repeat-containing domain superfamily

5 of 291

1.55

1.4

0.00054

IPR045111

Vacuolar protein sorting-associated protein Vps41/Vps8

2 of 2

3.32

1.4

0.0030

IPR032914

Vam6/VPS39/TRAP1 family

2 of 2

3.32

1.4

0.0030

IPR019453

Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2

2 of 2

3.32

1.4

0.0030

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00184

Ring finger

4 of 434

1.28

0.67

0.0306

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