LOC103479374 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103479374

Mitochondrial E3 ubiquitin protein ligase 1a. (356 aa)

Predicted Functional Partners:

usp30

0.738

ubxn7

0.676

tomm20

0.601

tomm70

0.601

tmem115

0.581

rps27a

0.531

LOC103471028

0.515

nr6a1

0.499

LOC103466630

0.474

fkbp8

0.474

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103466630	LOC103479374	ENSPREP00000009722	ENSPREP00000024145	Peptidylprolyl isomerase.	Mitochondrial E3 ubiquitin protein ligase 1a.	0.474
LOC103466630	tomm20	ENSPREP00000009722	ENSPREP00000011703	Peptidylprolyl isomerase.	Translocase of outer mitochondrial membrane 20b.	0.572
LOC103466630	tomm70	ENSPREP00000009722	ENSPREP00000026402	Peptidylprolyl isomerase.	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae).	0.549
LOC103466630	usp30	ENSPREP00000009722	ENSPREP00000032711	Peptidylprolyl isomerase.	Ubiquitin carboxyl-terminal hydrolase.	0.685
LOC103471028	LOC103479374	ENSPREP00000005102	ENSPREP00000024145	COMM domain containing 5.	Mitochondrial E3 ubiquitin protein ligase 1a.	0.515
LOC103471028	rps27a	ENSPREP00000005102	ENSPREP00000018427	COMM domain containing 5.	Ribosomal protein S27a.	0.878
LOC103479374	LOC103466630	ENSPREP00000024145	ENSPREP00000009722	Mitochondrial E3 ubiquitin protein ligase 1a.	Peptidylprolyl isomerase.	0.474
LOC103479374	LOC103471028	ENSPREP00000024145	ENSPREP00000005102	Mitochondrial E3 ubiquitin protein ligase 1a.	COMM domain containing 5.	0.515
LOC103479374	fkbp8	ENSPREP00000024145	ENSPREP00000013364	Mitochondrial E3 ubiquitin protein ligase 1a.	Peptidylprolyl isomerase.	0.474
LOC103479374	nr6a1	ENSPREP00000024145	ENSPREP00000019977	Mitochondrial E3 ubiquitin protein ligase 1a.	Nuclear receptor subfamily 6, group A, member 1a.	0.499
LOC103479374	rps27a	ENSPREP00000024145	ENSPREP00000018427	Mitochondrial E3 ubiquitin protein ligase 1a.	Ribosomal protein S27a.	0.531
LOC103479374	tmem115	ENSPREP00000024145	ENSPREP00000019740	Mitochondrial E3 ubiquitin protein ligase 1a.	Transmembrane protein 115.	0.581
LOC103479374	tomm20	ENSPREP00000024145	ENSPREP00000011703	Mitochondrial E3 ubiquitin protein ligase 1a.	Translocase of outer mitochondrial membrane 20b.	0.601
LOC103479374	tomm70	ENSPREP00000024145	ENSPREP00000026402	Mitochondrial E3 ubiquitin protein ligase 1a.	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae).	0.601
LOC103479374	ubxn7	ENSPREP00000024145	ENSPREP00000004268	Mitochondrial E3 ubiquitin protein ligase 1a.	UBX domain protein 7.	0.676
LOC103479374	usp30	ENSPREP00000024145	ENSPREP00000032711	Mitochondrial E3 ubiquitin protein ligase 1a.	Ubiquitin carboxyl-terminal hydrolase.	0.738
fkbp8	LOC103479374	ENSPREP00000013364	ENSPREP00000024145	Peptidylprolyl isomerase.	Mitochondrial E3 ubiquitin protein ligase 1a.	0.474
fkbp8	tomm20	ENSPREP00000013364	ENSPREP00000011703	Peptidylprolyl isomerase.	Translocase of outer mitochondrial membrane 20b.	0.572
fkbp8	tomm70	ENSPREP00000013364	ENSPREP00000026402	Peptidylprolyl isomerase.	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae).	0.549
fkbp8	usp30	ENSPREP00000013364	ENSPREP00000032711	Peptidylprolyl isomerase.	Ubiquitin carboxyl-terminal hydrolase.	0.685

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.783

expected number of edges:

12

PPI enrichment p-value:

0.00012

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007018

Microtubule-based movement

6 of 308

1.61

1.88

2.26e-05

GO:0046586

Regulation of calcium-dependent cell-cell adhesion

2 of 2

3.32

1.5

0.0020

GO:0007406

Negative regulation of neuroblast proliferation

2 of 3

3.14

1.42

0.0028

GO:0000070

Mitotic sister chromatid segregation

3 of 88

1.85

1.05

0.0089

GO:0070229

Negative regulation of lymphocyte apoptotic process

2 of 11

2.58

1.05

0.0121

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

3 of 21

2.47

1.8

0.00045

GO:0019894

Kinesin binding

3 of 40

2.19

1.6

0.00090

GO:0120170

Intraciliary transport particle B binding

2 of 4

3.02

1.48

0.0021

GO:0008017

Microtubule binding

4 of 271

1.49

1.09

0.0034

GO:0008092

Cytoskeletal protein binding

7 of 1110

1.12

1.02

0.00045

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005871

Kinesin complex

4 of 63

2.12

2.42

1.38e-05

GO:0016939

Kinesin II complex

2 of 2

3.32

2.04

0.00021

GO:0005828

Kinetochore microtubule

2 of 4

3.02

1.9

0.00036

GO:0097730

Non-motile cilium

4 of 123

1.83

1.84

0.00012

GO:0005876

Spindle microtubule

3 of 49

2.1

1.84

0.00025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17888

Intraciliary transport particle, and Kinesin II complex

4 of 27

2.49

2.82

4.52e-06

CL:8090

Mixed, incl. Mitotic spindle midzone, and Spindle elongation

3 of 13

2.68

2.51

2.31e-05

CL:17865

Mixed, incl. Transport along microtubule, and Kinesins

5 of 175

1.77

2.18

1.06e-05

CL:17932

Kinesin II complex, and Microtubule anchoring at centrosome

2 of 5

2.92

1.61

0.0012

CL:17896

Intraciliary transport particle B

2 of 5

2.92

1.61

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

6 of 98

2.1

3.79

5.77e-09

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

6 of 161

1.89

3.11

5.17e-08

MAP-8856688

Golgi-to-ER retrograde transport

6 of 191

1.81

2.9

9.36e-08

MAP-2132295

MHC class II antigen presentation

6 of 213

1.77

2.77

1.33e-07

MAP-983231

Factors involved in megakaryocyte development and platelet production

6 of 217

1.76

2.76

1.33e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016939

Kinesin II complex

2 of 3

3.14

1.66

0.0010

GOCC:0005871

Kinesin complex

3 of 43

2.16

1.58

0.00095

GOCC:0015630

Microtubule cytoskeleton

6 of 556

1.35

1.38

0.00014

GOCC:0051233

Spindle midzone

2 of 12

2.54

1.25

0.0052

GOCC:0005876

Spindle microtubule

2 of 17

2.39

1.17

0.0069

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0505

Motor protein

4 of 118

1.85

1.91

8.26e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01088

Ubiquitin carboxyl-terminal hydrolase, family 1

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001752

Kinesin motor domain

4 of 54

2.19

2.09

8.61e-05

IPR036961

Kinesin motor domain superfamily

4 of 109

1.88

1.57

0.00064

IPR041507

Peptidase C12, C-terminal domain

2 of 2

3.32

1.46

0.0024

IPR008658

Kinesin-associated protein 3

2 of 2

3.32

1.46

0.0024

IPR027640

Kinesin-like protein

3 of 40

2.19

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

4 of 51

2.21

2.59

7.58e-06

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