ENSPREP00000024183 protein (Poecilia reticulata)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

ENSPREP00000024183

Rho-GAP domain-containing protein. (214 aa)

Predicted Functional Partners:

Bcr

0.897

LOC103462133

0.593

LOC103479882

0.593

LOC103465968

0.593

myo9b

0.593

ephb3

0.582

grb2

0.538

arhgap1

0.516

CDC42

0.446

LOC103465423

0.446

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcr	CDC42	ENSPREP00000024152	ENSPREP00000005959	Si:dkey-91m11.5.	Cell division cycle 42.	0.446
Bcr	ENSPREP00000024183	ENSPREP00000024152	ENSPREP00000024183	Si:dkey-91m11.5.	Rho-GAP domain-containing protein.	0.897
Bcr	LOC103462133	ENSPREP00000024152	ENSPREP00000009559	Si:dkey-91m11.5.	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.593
Bcr	LOC103465423	ENSPREP00000024152	ENSPREP00000026666	Si:dkey-91m11.5.	Cell division cycle 42.	0.446
Bcr	LOC103465968	ENSPREP00000024152	ENSPREP00000019934	Si:dkey-91m11.5.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.593
Bcr	LOC103479882	ENSPREP00000024152	ENSPREP00000019878	Si:dkey-91m11.5.	Myosin IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.593
Bcr	arhgap1	ENSPREP00000024152	ENSPREP00000026198	Si:dkey-91m11.5.	Uncharacterized protein.	0.516
Bcr	ephb3	ENSPREP00000024152	ENSPREP00000010606	Si:dkey-91m11.5.	Receptor protein-tyrosine kinase.	0.582
Bcr	grb2	ENSPREP00000024152	ENSPREP00000022510	Si:dkey-91m11.5.	Growth factor receptor-bound protein 2b.	0.538
Bcr	myo9b	ENSPREP00000024152	ENSPREP00000025222	Si:dkey-91m11.5.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.593
CDC42	Bcr	ENSPREP00000005959	ENSPREP00000024152	Cell division cycle 42.	Si:dkey-91m11.5.	0.446
CDC42	ENSPREP00000024183	ENSPREP00000005959	ENSPREP00000024183	Cell division cycle 42.	Rho-GAP domain-containing protein.	0.446
CDC42	LOC103462133	ENSPREP00000005959	ENSPREP00000009559	Cell division cycle 42.	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.659
CDC42	LOC103465968	ENSPREP00000005959	ENSPREP00000019934	Cell division cycle 42.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.659
CDC42	LOC103479882	ENSPREP00000005959	ENSPREP00000019878	Cell division cycle 42.	Myosin IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.655
CDC42	arhgap1	ENSPREP00000005959	ENSPREP00000026198	Cell division cycle 42.	Uncharacterized protein.	0.959
CDC42	grb2	ENSPREP00000005959	ENSPREP00000022510	Cell division cycle 42.	Growth factor receptor-bound protein 2b.	0.669
CDC42	myo9b	ENSPREP00000005959	ENSPREP00000025222	Cell division cycle 42.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.659
ENSPREP00000024183	Bcr	ENSPREP00000024183	ENSPREP00000024152	Rho-GAP domain-containing protein.	Si:dkey-91m11.5.	0.897
ENSPREP00000024183	CDC42	ENSPREP00000024183	ENSPREP00000005959	Rho-GAP domain-containing protein.	Cell division cycle 42.	0.446

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.905

expected number of edges:

17

PPI enrichment p-value:

0.0865

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032224

Positive regulation of synaptic transmission, cholinergic

3 of 5

3.1

2.82

7.57e-06

GO:0045995

Regulation of embryonic development

4 of 61

2.13

2.33

2.24e-05

GO:0000904

Cell morphogenesis involved in differentiation

7 of 515

1.45

1.89

2.56e-06

GO:0009887

Animal organ morphogenesis

8 of 749

1.35

1.74

1.71e-06

GO:0007411

Axon guidance

5 of 249

1.62

1.74

7.22e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005201

Extracellular matrix structural constituent

6 of 134

1.97

3.22

5.71e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005604

Basement membrane

8 of 77

2.33

6.55

5.35e-15

GO:0031012

Extracellular matrix

9 of 489

1.58

3.08

3.42e-11

GO:0043083

Synaptic cleft

3 of 9

2.84

2.95

3.81e-06

GO:0031594

Neuromuscular junction

3 of 44

2.15

1.86

0.00024

GO:0042383

Sarcolemma

3 of 77

1.91

1.49

0.0010

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36142434

(2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii).

3 of 13

2.68

2.39

3.80e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21899

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

8 of 14

3.07

10.0

1.42e-19

CL:21782

ECM-receptor interaction, and Laminin interactions

9 of 77

2.39

7.74

8.90e-18

CL:21901

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

4 of 7

3.07

4.56

4.34e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04512

ECM-receptor interaction

5 of 84

2.09

3.38

6.00e-08

pret04510

Focal adhesion

5 of 212

1.69

2.26

2.69e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000157

Laminin interactions

8 of 40

2.62

8.04

5.57e-17

MAP-8874081

MET activates PTK2 signaling

5 of 22

2.67

4.84

5.93e-10

MAP-8875878

MET promotes cell motility

5 of 38

2.44

4.23

4.69e-09

MAP-6806834

Signaling by MET

5 of 78

2.12

3.36

8.42e-08

MAP-3000171

Non-integrin membrane-ECM interactions

4 of 51

2.21

2.79

2.70e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

3 of 407

1.19

0.81

0.0076

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005604

Basement membrane

8 of 56

2.47

7.27

6.00e-16

GOCC:0062023

Collagen-containing extracellular matrix

9 of 190

1.99

5.33

9.90e-15

GOCC:0005610

laminin-5 complex

4 of 7

3.07

4.6

3.65e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0424

Laminin EGF-like domain

5 of 38

2.44

4.33

2.83e-09

KW-1015

Disulfide bond

5 of 1351

0.89

0.49

0.0415

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002049

Laminin-type EGF domain

6 of 51

2.39

4.58

5.94e-10

IPR000034

Laminin IV

4 of 6

3.14

4.2

2.16e-08

IPR008211

Laminin, N-terminal

4 of 23

2.56

3.14

1.20e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00180

Laminin-type epidermal growth factor-like domai

6 of 42

2.47

5.32

2.20e-11

SM00136

Laminin N-terminal domain (domain VI)

4 of 22

2.58

3.57

1.67e-07

SM00001

EGF domain, unclasssified subfamily

4 of 92

1.96

2.21

2.44e-05

SM00281

Laminin B domain

2 of 4

3.02

1.78

0.00061

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