STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSPREP00000024568BHLH domain-containing protein. (197 aa)    
Predicted Functional Partners:
scap
SREBF chaperone.
   
 0.941
Srebf2
Uncharacterized protein.
 
      0.900
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.809
kpnb1
Karyopherin (importin) beta 1.
    
 0.807
npc1
Niemann-Pick disease, type C1.
   
 0.807
mbtps2
Membrane-bound transcription factor peptidase, site 2.
    
 0.749
mbtps1
Membrane-bound transcription factor peptidase, site 1.
     
 0.660
LOC103468460
E1A binding protein p300 b.
    
 0.547
LOC103482005
E1A binding protein p300 a.
    
 0.547
MED15
Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 
 0.540
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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