gga3 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

gga3

Golgi associated, gamma adaptin ear containing, ARF binding protein 3a. (742 aa)

Predicted Functional Partners:

rabep1

0.966

igf2r

0.935

m6pr

0.934

ENSPREP00000016383

0.884

ENSPREP00000022524

0.884

rps27a

0.873

uba52

0.836

ubb

0.761

ENSPREP00000009964

0.761

LOC103473189

0.761

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009964	gga3	ENSPREP00000009964	ENSPREP00000024595	Ubiquitin-like domain-containing protein.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	0.761
ENSPREP00000009964	rps27a	ENSPREP00000009964	ENSPREP00000018427	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.924
ENSPREP00000009964	uba52	ENSPREP00000009964	ENSPREP00000016516	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.954
ENSPREP00000016383	gga3	ENSPREP00000016383	ENSPREP00000024595	ADP-ribosylation factor 6b.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	0.884
ENSPREP00000016383	igf2r	ENSPREP00000016383	ENSPREP00000026805	ADP-ribosylation factor 6b.	Insulin-like growth factor 2 receptor.	0.430
ENSPREP00000022524	gga3	ENSPREP00000022524	ENSPREP00000024595	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	0.884
ENSPREP00000022524	igf2r	ENSPREP00000022524	ENSPREP00000026805	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Insulin-like growth factor 2 receptor.	0.430
LOC103473189	gga3	ENSPREP00000021152	ENSPREP00000024595	Uncharacterized protein.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	0.761
LOC103473189	rps27a	ENSPREP00000021152	ENSPREP00000018427	Uncharacterized protein.	Ribosomal protein S27a.	0.953
LOC103473189	uba52	ENSPREP00000021152	ENSPREP00000016516	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.972
gga3	ENSPREP00000009964	ENSPREP00000024595	ENSPREP00000009964	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Ubiquitin-like domain-containing protein.	0.761
gga3	ENSPREP00000016383	ENSPREP00000024595	ENSPREP00000016383	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	ADP-ribosylation factor 6b.	0.884
gga3	ENSPREP00000022524	ENSPREP00000024595	ENSPREP00000022524	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.884
gga3	LOC103473189	ENSPREP00000024595	ENSPREP00000021152	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Uncharacterized protein.	0.761
gga3	igf2r	ENSPREP00000024595	ENSPREP00000026805	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Insulin-like growth factor 2 receptor.	0.935
gga3	m6pr	ENSPREP00000024595	ENSPREP00000014921	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Mannose-6-phosphate receptor (cation dependent).	0.934
gga3	rabep1	ENSPREP00000024595	ENSPREP00000021547	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Rabaptin, RAB GTPase binding effector protein 1.	0.966
gga3	rps27a	ENSPREP00000024595	ENSPREP00000018427	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Ribosomal protein S27a.	0.873
gga3	uba52	ENSPREP00000024595	ENSPREP00000016516	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.836
gga3	ubb	ENSPREP00000024595	ENSPREP00000009876	Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.	Uncharacterized protein.	0.761

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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