dapk1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

dapk1

Death-associated protein kinase 1. (1444 aa)

Predicted Functional Partners:

becn1

0.916

calm2

0.615

calm1

0.615

calm3

0.615

LOC103470713

0.489

LOC103470685

0.477

fbxo4

0.475

LOC103475843

0.423

cask

0.423

Rab42

0.422

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103470685	LOC103470713	ENSPREP00000019504	ENSPREP00000019600	Uncharacterized protein.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.655
LOC103470685	dapk1	ENSPREP00000019504	ENSPREP00000024778	Uncharacterized protein.	Death-associated protein kinase 1.	0.477
LOC103470713	LOC103470685	ENSPREP00000019600	ENSPREP00000019504	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Uncharacterized protein.	0.655
LOC103470713	dapk1	ENSPREP00000019600	ENSPREP00000024778	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Death-associated protein kinase 1.	0.489
LOC103475843	calm1	ENSPREP00000013706	ENSPREP00000027421	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.673
LOC103475843	calm2	ENSPREP00000013706	ENSPREP00000015904	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.673
LOC103475843	calm3	ENSPREP00000013706	ENSPREP00000033844	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Calmodulin 3.	0.673
LOC103475843	cask	ENSPREP00000013706	ENSPREP00000030734	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the MAGUK family.	0.761
LOC103475843	dapk1	ENSPREP00000013706	ENSPREP00000024778	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Death-associated protein kinase 1.	0.423
Rab42	dapk1	ENSPREP00000007240	ENSPREP00000024778	Si:dkey-34d22.5.	Death-associated protein kinase 1.	0.422
becn1	dapk1	ENSPREP00000033133	ENSPREP00000024778	Beclin 1, autophagy related.	Death-associated protein kinase 1.	0.916
calm1	LOC103475843	ENSPREP00000027421	ENSPREP00000013706	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.673
calm1	cask	ENSPREP00000027421	ENSPREP00000030734	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the MAGUK family.	0.673
calm1	dapk1	ENSPREP00000027421	ENSPREP00000024778	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Death-associated protein kinase 1.	0.615
calm2	LOC103475843	ENSPREP00000015904	ENSPREP00000013706	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.673
calm2	cask	ENSPREP00000015904	ENSPREP00000030734	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the MAGUK family.	0.673
calm2	dapk1	ENSPREP00000015904	ENSPREP00000024778	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Death-associated protein kinase 1.	0.615
calm3	LOC103475843	ENSPREP00000033844	ENSPREP00000013706	Calmodulin 3.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.673
calm3	cask	ENSPREP00000033844	ENSPREP00000030734	Calmodulin 3.	Uncharacterized protein; Belongs to the MAGUK family.	0.673
calm3	dapk1	ENSPREP00000033844	ENSPREP00000024778	Calmodulin 3.	Death-associated protein kinase 1.	0.615

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.714

expected number of edges:

25

PPI enrichment p-value:

0.0932

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

10 of 335

1.79

4.36

4.73e-14

GO:0006397

mRNA processing

10 of 420

1.69

3.84

2.19e-13

GO:0000398

mRNA splicing, via spliceosome

7 of 217

1.83

3.34

3.40e-09

GO:0051028

mRNA transport

4 of 90

1.97

2.11

4.38e-05

GO:0010467

Gene expression

11 of 1665

1.14

1.61

5.16e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1169

1.29

2.14

1.77e-11

GO:0003729

mRNA binding

4 of 282

1.47

1.06

0.0040

GO:0000339

RNA cap binding

2 of 16

2.41

1.01

0.0143

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 2

3.32

1.55

0.0016

GO:0016607

Nuclear speck

4 of 269

1.49

1.18

0.0019

GO:0002102

Podosome

2 of 18

2.36

1.16

0.0072

GO:0016604

Nuclear body

5 of 483

1.33

1.09

0.0016

GO:0005681

Spliceosomal complex

3 of 167

1.57

0.97

0.0089

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37941135

(2023) Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection.

2 of 15

2.44

0.89

0.0234

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2649

RNA Polymerase II Transcription Termination, and mRNA Splicing - Major Pathway

11 of 130

2.25

8.36

1.64e-21

CL:2657

RNA recognition motif domain

8 of 71

2.37

6.63

5.76e-15

CL:2737

mRNA 3-end processing

4 of 22

2.58

3.37

4.30e-07

CL:2739

Mixed, incl. SRSF7, RNA recognition motif, and SRSF1, RNA recognition motif 1

3 of 13

2.68

2.46

2.89e-05

CL:2665

Mixed, incl. ROK, N-terminal, and TAF15/EWS/TLS family

3 of 13

2.68

2.46

2.89e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03040

Spliceosome

9 of 120

2.19

6.81

3.94e-17

pret03015

mRNA surveillance pathway

3 of 76

1.91

1.63

0.00050

pret05168

Herpes simplex virus 1 infection

4 of 268

1.49

1.37

0.00050

pret03013

RNA transport

3 of 136

1.66

1.31

0.0015

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 251

1.96

6.14

6.02e-19

MAP-72172

mRNA Splicing

11 of 272

1.92

5.93

7.14e-19

MAP-73856

RNA Polymerase II Transcription Termination

7 of 78

2.27

5.56

8.26e-13

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 362

1.8

5.04

1.04e-17

MAP-72187

mRNA 3-end processing

6 of 67

2.27

4.73

1.08e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 79

2.02

2.03

8.00e-05

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.14

1.64

0.0011

GOCC:0002102

Podosome

2 of 25

2.22

0.89

0.0225

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

8 of 325

1.71

3.4

9.87e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

8 of 233

1.85

3.77

1.54e-10

IPR035979

RNA-binding domain superfamily

8 of 257

1.81

3.65

1.66e-10

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

8 of 264

1.8

3.62

1.66e-10

IPR012987

ROK, N-terminal

2 of 2

3.32

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

8 of 227

1.86

4.08

1.38e-11

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