LOC103462988 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

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[Homology]

Score

LOC103462988

Uncharacterized protein. (521 aa)

Predicted Functional Partners:

nrip1

0.734

ncor2

0.658

ncor1

0.658

LOC103475715

0.538

TADA1

0.532

LOC103468951

0.502

CLOCK

0.502

LOC103468460

0.491

LOC103482005

0.491

ppargc1a

0.458

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLOCK	LOC103462988	ENSPREP00000029360	ENSPREP00000024870	Clock circadian regulator a.	Uncharacterized protein.	0.502
CLOCK	LOC103468460	ENSPREP00000029360	ENSPREP00000026558	Clock circadian regulator a.	E1A binding protein p300 b.	0.545
CLOCK	LOC103482005	ENSPREP00000029360	ENSPREP00000030842	Clock circadian regulator a.	E1A binding protein p300 a.	0.545
LOC103462988	CLOCK	ENSPREP00000024870	ENSPREP00000029360	Uncharacterized protein.	Clock circadian regulator a.	0.502
LOC103462988	LOC103468460	ENSPREP00000024870	ENSPREP00000026558	Uncharacterized protein.	E1A binding protein p300 b.	0.491
LOC103462988	LOC103468951	ENSPREP00000024870	ENSPREP00000018328	Uncharacterized protein.	Uncharacterized protein.	0.502
LOC103462988	LOC103475715	ENSPREP00000024870	ENSPREP00000031107	Uncharacterized protein.	Neuronal PAS domain protein 2.	0.538
LOC103462988	LOC103482005	ENSPREP00000024870	ENSPREP00000030842	Uncharacterized protein.	E1A binding protein p300 a.	0.491
LOC103462988	TADA1	ENSPREP00000024870	ENSPREP00000005904	Uncharacterized protein.	Transcriptional adaptor 1.	0.532
LOC103462988	ncor1	ENSPREP00000024870	ENSPREP00000009626	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.658
LOC103462988	ncor2	ENSPREP00000024870	ENSPREP00000001887	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.658
LOC103462988	nrip1	ENSPREP00000024870	ENSPREP00000015830	Uncharacterized protein.	Nuclear receptor interacting protein 1b.	0.734
LOC103462988	ppargc1a	ENSPREP00000024870	ENSPREP00000028362	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.458
LOC103468460	CLOCK	ENSPREP00000026558	ENSPREP00000029360	E1A binding protein p300 b.	Clock circadian regulator a.	0.545
LOC103468460	LOC103462988	ENSPREP00000026558	ENSPREP00000024870	E1A binding protein p300 b.	Uncharacterized protein.	0.491
LOC103468460	LOC103468951	ENSPREP00000026558	ENSPREP00000018328	E1A binding protein p300 b.	Uncharacterized protein.	0.545
LOC103468460	LOC103475715	ENSPREP00000026558	ENSPREP00000031107	E1A binding protein p300 b.	Neuronal PAS domain protein 2.	0.545
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902
LOC103468460	TADA1	ENSPREP00000026558	ENSPREP00000005904	E1A binding protein p300 b.	Transcriptional adaptor 1.	0.521
LOC103468460	ncor1	ENSPREP00000026558	ENSPREP00000009626	E1A binding protein p300 b.	Nuclear receptor corepressor 1.	0.616

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

2.15e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000077

DNA damage checkpoint signaling

7 of 79

2.27

5.21

6.50e-12

GO:0044773

Mitotic DNA damage checkpoint signaling

6 of 63

2.3

4.64

2.28e-10

GO:0071479

Cellular response to ionizing radiation

5 of 38

2.44

4.27

3.82e-09

GO:0007095

Mitotic G2 DNA damage checkpoint signaling

5 of 41

2.4

4.2

4.66e-09

GO:0006281

DNA repair

10 of 415

1.7

3.87

1.94e-13

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030870

Mre11 complex

3 of 3

3.32

3.31

1.04e-06

GO:0000781

Chromosome, telomeric region

4 of 56

2.17

2.62

5.85e-06

GO:0031436

BRCA1-BARD1 complex

2 of 3

3.14

2.02

0.00022

GO:0000794

Condensed nuclear chromosome

3 of 49

2.1

1.87

0.00021

GO:0035861

Site of double-strand break

3 of 52

2.08

1.86

0.00022

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32796846

(2020) A scalable CRISPRCas9-based fluorescent reporter assay to study DNA double-strand break repair choice.

3 of 25

2.4

1.95

0.00022

PMID:38102134

(2023) Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.

3 of 42

2.17

1.73

0.00048

PMID:33742045

(2021) Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma.

2 of 11

2.58

1.28

0.0045

PMID:37627523

(2023) Natural Acetogenins, Chatenaytrienins-1, -2, -3 and -4, Mitochondrial Potential Uncouplers and Autophagy Inducers-Promising Anticancer Agents.

2 of 36

2.06

0.81

0.0301

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7103

Mixed, incl. Mre11 complex, and BRCA1-BARD1 complex

9 of 11

3.23

12.3

9.80e-24

CL:7105

Mre11 complex, and Flap-structured DNA binding

4 of 5

3.22

4.77

2.02e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03440

Homologous recombination

5 of 27

2.59

5.06

1.47e-10

pret04218

Cellular senescence

8 of 178

1.97

4.81

4.42e-13

pret04115

p53 signaling pathway

5 of 78

2.12

3.67

1.40e-08

pret04110

Cell cycle

5 of 120

1.94

3.11

8.41e-08

pret03450

Non-homologous end-joining

2 of 11

2.58

1.77

0.00054

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69473

G2/M DNA damage checkpoint

10 of 101

2.31

8.16

8.73e-20

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

10 of 125

2.22

7.56

3.33e-19

MAP-5685938

HDR through Single Strand Annealing (SSA)

7 of 45

2.51

6.75

1.61e-14

MAP-5693616

Presynaptic phase of homologous DNA pairing and strand exchange

6 of 24

2.72

6.57

1.91e-13

MAP-5693579

Homologous DNA Pairing and Strand Exchange

6 of 26

2.68

6.48

2.49e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030870

Mre11 complex

4 of 5

3.22

4.53

5.58e-09

GOCC:0031436

BRCA1-BARD1 complex

2 of 5

2.92

1.46

0.0023

GOCC:0070531

BRCA1-A complex

2 of 15

2.44

1.12

0.0087

GOCC:0005634

Nucleus

10 of 3523

0.77

0.71

5.55e-05

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.31

0.0100

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0227

DNA damage

2 of 27

2.19

0.84

0.0283

KW-0723

Serine/threonine-protein kinase

3 of 233

1.43

0.73

0.0283

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02259

FAT domain

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036420

BRCT domain superfamily

4 of 27

2.49

2.75

6.43e-06

IPR001357

BRCT domain

3 of 23

2.43

1.68

0.00076

IPR003151

PIK-related kinase, FAT

2 of 4

3.02

1.18

0.0075

IPR014009

PIK-related kinase

2 of 5

2.92

1.17

0.0078

IPR003152

FATC domain

2 of 6

2.84

1.15

0.0083

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00292

Breast cancer carboxy-terminal domain

4 of 22

2.58

3.42

3.35e-07

SM01343

The FATC domain is named after FRAP, ATM, TRRAP C-terminal (PMID:10782091). The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability (PMID:15772072).

2 of 6

2.84

1.45

0.0023

SM00240

Forkhead associated domain

2 of 27

2.19

0.89

0.0220

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