ENSPREP00000024995 protein (Poecilia reticulata)

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Known Interactions

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experimentally determined

Predicted Interactions

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gene co-occurrence

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protein homology

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Score

ENSPREP00000024995

Protein kinase domain-containing protein. (161 aa)

Predicted Functional Partners:

YES1

0.932

LOC103479892

0.932

ctnnb1

0.921

LOC103472282

0.918

LOC103463938

0.907

CTNND1

0.907

LOC108165961

0.900

ENSPREP00000024937

0.900

hsp90ab1

0.484

LOC103457917

0.484

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNND1	ENSPREP00000024995	ENSPREP00000026535	ENSPREP00000024995	Catenin delta 1.	Protein kinase domain-containing protein.	0.907
CTNND1	LOC103463938	ENSPREP00000026535	ENSPREP00000002099	Catenin delta 1.	Catenin (cadherin-associated protein), delta 1.	0.902
CTNND1	LOC103472282	ENSPREP00000026535	ENSPREP00000005903	Catenin delta 1.	Uncharacterized protein.	0.635
CTNND1	LOC103479892	ENSPREP00000026535	ENSPREP00000022831	Catenin delta 1.	Tyrosine-protein kinase.	0.910
CTNND1	YES1	ENSPREP00000026535	ENSPREP00000011214	Catenin delta 1.	Tyrosine-protein kinase.	0.910
CTNND1	ctnnb1	ENSPREP00000026535	ENSPREP00000019419	Catenin delta 1.	Catenin (cadherin-associated protein), beta 1.	0.836
ENSPREP00000024937	ENSPREP00000024995	ENSPREP00000024937	ENSPREP00000024995	SH2 domain-containing protein.	Protein kinase domain-containing protein.	0.900
ENSPREP00000024937	LOC103457917	ENSPREP00000024937	ENSPREP00000020946	SH2 domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.484
ENSPREP00000024937	LOC108165961	ENSPREP00000024937	ENSPREP00000024919	SH2 domain-containing protein.	F-BAR domain-containing protein.	0.900
ENSPREP00000024937	hsp90ab1	ENSPREP00000024937	ENSPREP00000012481	SH2 domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.484
ENSPREP00000024995	CTNND1	ENSPREP00000024995	ENSPREP00000026535	Protein kinase domain-containing protein.	Catenin delta 1.	0.907
ENSPREP00000024995	ENSPREP00000024937	ENSPREP00000024995	ENSPREP00000024937	Protein kinase domain-containing protein.	SH2 domain-containing protein.	0.900
ENSPREP00000024995	LOC103457917	ENSPREP00000024995	ENSPREP00000020946	Protein kinase domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.484
ENSPREP00000024995	LOC103463938	ENSPREP00000024995	ENSPREP00000002099	Protein kinase domain-containing protein.	Catenin (cadherin-associated protein), delta 1.	0.907
ENSPREP00000024995	LOC103472282	ENSPREP00000024995	ENSPREP00000005903	Protein kinase domain-containing protein.	Uncharacterized protein.	0.918
ENSPREP00000024995	LOC103479892	ENSPREP00000024995	ENSPREP00000022831	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.932
ENSPREP00000024995	LOC108165961	ENSPREP00000024995	ENSPREP00000024919	Protein kinase domain-containing protein.	F-BAR domain-containing protein.	0.900
ENSPREP00000024995	YES1	ENSPREP00000024995	ENSPREP00000011214	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.932
ENSPREP00000024995	ctnnb1	ENSPREP00000024995	ENSPREP00000019419	Protein kinase domain-containing protein.	Catenin (cadherin-associated protein), beta 1.	0.921
ENSPREP00000024995	hsp90ab1	ENSPREP00000024995	ENSPREP00000012481	Protein kinase domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.484

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

16

PPI enrichment p-value:

7.99e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 5

2.31

1.56

0.0012

GO:0051276

Chromosome organization

4 of 27

1.7

1.37

0.0012

GO:0006259

DNA metabolic process

5 of 139

1.09

0.74

0.0085

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003916

DNA topoisomerase activity

3 of 5

2.31

1.69

0.00066

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

2 of 4

2.23

0.93

0.0186

GO:0140097

Catalytic activity, acting on DNA

4 of 76

1.25

0.74

0.0179

GO:0003677

DNA binding

6 of 280

0.86

0.55

0.0179

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4965

Mixed, incl. Chromosome condensation, and SPFH domain / Band 7 family

5 of 5

2.53

4.28

5.25e-09

CL:4962

Mostly uncharacterized, incl. Virulence factor BrkB, and Chromosome condensation

6 of 12

2.23

4.17

1.84e-09

CL:505

Mixed, incl. 3-5 exonuclease, and RecQ zinc-binding

2 of 5

2.13

0.96

0.0158

CL:500

Homologous recombination, and ATP-dependent activity, acting on DNA

3 of 35

1.47

0.84

0.0158

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

2 of 4

2.23

0.89

0.0231

KW-0175

Coiled coil

7 of 515

0.67

0.42

0.0231

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006171

TOPRIM domain

3 of 5

2.31

1.52

0.0014

IPR018522

DNA topoisomerase, type IIA, conserved site

2 of 2

2.53

0.83

0.0310

IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal

2 of 2

2.53

0.83

0.0310

IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2

2 of 2

2.53

0.83

0.0310

IPR001241

DNA topoisomerase, type IIA

2 of 2

2.53

0.83

0.0310

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00433

TopoisomeraseII

2 of 2

2.53

1.26

0.0050

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