NFYB protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NFYB

Nuclear transcription factor Y, beta a. (209 aa)

Predicted Functional Partners:

nfyc

0.978

nfya

0.978

chrac1

0.914

LOC103479772

0.870

pole4

0.532

GATA2

0.531

LOC103465060

0.531

gata3

0.531

pole2

0.496

LOC103463524

0.458

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA2	LOC103479772	ENSPREP00000018023	ENSPREP00000017817	GATA binding protein 2.	Im:7138239.	0.417
GATA2	NFYB	ENSPREP00000018023	ENSPREP00000025063	GATA binding protein 2.	Nuclear transcription factor Y, beta a.	0.531
GATA2	chrac1	ENSPREP00000018023	ENSPREP00000011353	GATA binding protein 2.	Chromatin accessibility complex subunit 1.	0.498
GATA2	nfya	ENSPREP00000018023	ENSPREP00000021753	GATA binding protein 2.	Nuclear transcription factor Y, alpha, like.	0.462
GATA2	nfyc	ENSPREP00000018023	ENSPREP00000008518	GATA binding protein 2.	Nuclear transcription factor Y, gamma.	0.623
LOC103463524	NFYB	ENSPREP00000019018	ENSPREP00000025063	SCY domain-containing protein.	Nuclear transcription factor Y, beta a.	0.458
LOC103463524	pole2	ENSPREP00000019018	ENSPREP00000007160	SCY domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.975
LOC103465060	LOC103479772	ENSPREP00000026296	ENSPREP00000017817	GATA binding protein 2a.	Im:7138239.	0.417
LOC103465060	NFYB	ENSPREP00000026296	ENSPREP00000025063	GATA binding protein 2a.	Nuclear transcription factor Y, beta a.	0.531
LOC103465060	chrac1	ENSPREP00000026296	ENSPREP00000011353	GATA binding protein 2a.	Chromatin accessibility complex subunit 1.	0.498
LOC103465060	nfya	ENSPREP00000026296	ENSPREP00000021753	GATA binding protein 2a.	Nuclear transcription factor Y, alpha, like.	0.462
LOC103465060	nfyc	ENSPREP00000026296	ENSPREP00000008518	GATA binding protein 2a.	Nuclear transcription factor Y, gamma.	0.623
LOC103479772	GATA2	ENSPREP00000017817	ENSPREP00000018023	Im:7138239.	GATA binding protein 2.	0.417
LOC103479772	LOC103465060	ENSPREP00000017817	ENSPREP00000026296	Im:7138239.	GATA binding protein 2a.	0.417
LOC103479772	NFYB	ENSPREP00000017817	ENSPREP00000025063	Im:7138239.	Nuclear transcription factor Y, beta a.	0.870
LOC103479772	gata3	ENSPREP00000017817	ENSPREP00000026693	Im:7138239.	GATA binding protein 3.	0.417
LOC103479772	nfya	ENSPREP00000017817	ENSPREP00000021753	Im:7138239.	Nuclear transcription factor Y, alpha, like.	0.941
LOC103479772	pole2	ENSPREP00000017817	ENSPREP00000007160	Im:7138239.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.468
NFYB	GATA2	ENSPREP00000025063	ENSPREP00000018023	Nuclear transcription factor Y, beta a.	GATA binding protein 2.	0.531
NFYB	LOC103463524	ENSPREP00000025063	ENSPREP00000019018	Nuclear transcription factor Y, beta a.	SCY domain-containing protein.	0.458

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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