LOC103479399 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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co-expression

protein homology

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Score

LOC103479399

Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (548 aa)

Predicted Functional Partners:

LOC103478412

0.590

rnf11

0.560

LOC103478962

0.550

hao1

0.550

LOC103465933

0.529

ndrg4

0.525

LOC103467415

0.524

notum

0.495

LOC103464810

0.495

LOC103468852

0.495

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103464810	LOC103468852	ENSPREP00000000665	ENSPREP00000003213	Notum pectinacetylesterase 2.	Notum, palmitoleoyl-protein carboxylesterase a.	0.902
LOC103464810	LOC103479399	ENSPREP00000000665	ENSPREP00000025503	Notum pectinacetylesterase 2.	Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.495
LOC103464810	notum	ENSPREP00000000665	ENSPREP00000000580	Notum pectinacetylesterase 2.	Uncharacterized protein.	0.903
LOC103465933	LOC103467415	ENSPREP00000018228	ENSPREP00000029363	Interferon induced transmembrane protein 5.	Troponin T type 2a (cardiac).	0.478
LOC103465933	LOC103478962	ENSPREP00000018228	ENSPREP00000004110	Interferon induced transmembrane protein 5.	Mohawk homeobox b.	0.552
LOC103465933	LOC103479399	ENSPREP00000018228	ENSPREP00000025503	Interferon induced transmembrane protein 5.	Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.529
LOC103465933	hao1	ENSPREP00000018228	ENSPREP00000016637	Interferon induced transmembrane protein 5.	Hydroxyacid oxidase (glycolate oxidase) 1.	0.536
LOC103465933	ndrg4	ENSPREP00000018228	ENSPREP00000003838	Interferon induced transmembrane protein 5.	NDRG family member 4.	0.485
LOC103465933	rnf11	ENSPREP00000018228	ENSPREP00000027408	Interferon induced transmembrane protein 5.	Ring finger protein 11b.	0.531
LOC103467415	LOC103465933	ENSPREP00000029363	ENSPREP00000018228	Troponin T type 2a (cardiac).	Interferon induced transmembrane protein 5.	0.478
LOC103467415	LOC103478962	ENSPREP00000029363	ENSPREP00000004110	Troponin T type 2a (cardiac).	Mohawk homeobox b.	0.524
LOC103467415	LOC103479399	ENSPREP00000029363	ENSPREP00000025503	Troponin T type 2a (cardiac).	Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.524
LOC103467415	hao1	ENSPREP00000029363	ENSPREP00000016637	Troponin T type 2a (cardiac).	Hydroxyacid oxidase (glycolate oxidase) 1.	0.537
LOC103467415	ndrg4	ENSPREP00000029363	ENSPREP00000003838	Troponin T type 2a (cardiac).	NDRG family member 4.	0.475
LOC103467415	rnf11	ENSPREP00000029363	ENSPREP00000027408	Troponin T type 2a (cardiac).	Ring finger protein 11b.	0.526
LOC103468852	LOC103464810	ENSPREP00000003213	ENSPREP00000000665	Notum, palmitoleoyl-protein carboxylesterase a.	Notum pectinacetylesterase 2.	0.902
LOC103468852	LOC103479399	ENSPREP00000003213	ENSPREP00000025503	Notum, palmitoleoyl-protein carboxylesterase a.	Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.495
LOC103468852	notum	ENSPREP00000003213	ENSPREP00000000580	Notum, palmitoleoyl-protein carboxylesterase a.	Uncharacterized protein.	0.901
LOC103478412	LOC103479399	ENSPREP00000014097	ENSPREP00000025503	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.590
LOC103478962	LOC103465933	ENSPREP00000004110	ENSPREP00000018228	Mohawk homeobox b.	Interferon induced transmembrane protein 5.	0.552

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Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.855

expected number of edges:

10

PPI enrichment p-value:

0.231

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035019

Somatic stem cell population maintenance

2 of 9

2.66

1.21

0.0062

GO:0006357

Regulation of transcription by RNA polymerase II

10 of 2320

0.95

0.99

9.61e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003712

Transcription coregulator activity

10 of 414

1.7

3.91

1.25e-13

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016592

Mediator complex

11 of 40

2.76

12.87

2.68e-27

GO:0070847

Core mediator complex

5 of 10

3.02

5.91

1.12e-11

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10934

Mediator complex

11 of 14

3.21

15.79

9.97e-31

CL:10937

Core mediator complex, and Mediator complex, subunit Med7/Med21-like

7 of 7

3.32

9.93

4.85e-19

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-381340

Transcriptional regulation of white adipocyte differentiation

4 of 37

2.35

2.75

4.84e-06

MAP-400206

Regulation of lipid metabolism by PPARalpha

4 of 60

2.14

2.42

1.51e-05

MAP-212436

Generic Transcription Pathway

7 of 1362

1.03

0.93

0.00040

MAP-73857

RNA Polymerase II Transcription

7 of 1529

0.98

0.85

0.00066

MAP-74160

Gene expression (Transcription)

7 of 1853

0.89

0.71

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016592

Mediator complex

5 of 23

2.65

4.65

1.33e-09

GOCC:0005634

Nucleus

11 of 3523

0.81

0.83

9.08e-07

GOCC:0032991

Protein-containing complex

11 of 4807

0.68

0.62

1.84e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

8 of 52

2.5

7.72

7.57e-17

KW-0805

Transcription regulation

8 of 356

1.67

3.28

1.01e-10

KW-0539

Nucleus

8 of 1189

1.15

1.41

6.59e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037212

Mediator complex, subunit Med7/Med21-like

2 of 3

3.14

1.02

0.0149

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