STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)    
Predicted Functional Partners:
CDC25B
Cell division cycle 25B.
   
 0.998
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.998
chek2
Checkpoint kinase 2.
   
0.993
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.991
CLSPN
Claspin.
   
 0.985
atm
Non-specific serine/threonine protein kinase.
    
 0.984
mcm4
DNA helicase; Belongs to the MCM family.
   
 0.978
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.967
tp53bp1
Tumor protein p53 binding protein, 1.
    
 
 0.958
rad51
RAD51 recombinase.
   
 0.954
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.