mxd1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

mxd1

MAX dimerization protein 1. (222 aa)

Predicted Functional Partners:

ENSPREP00000015321

0.920

MAX

0.920

LOC103462700

0.768

sin3a

0.768

sin3b

0.768

add2

0.643

suds3

0.599

tfdp1

0.532

Slc31a2

0.479

LOC103476186

0.477

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000015321	MAX	ENSPREP00000015321	ENSPREP00000029247	Myc associated factor X.	MYC associated factor X.	0.901
ENSPREP00000015321	add2	ENSPREP00000015321	ENSPREP00000026103	Myc associated factor X.	Adducin 2 (beta).	0.550
ENSPREP00000015321	mxd1	ENSPREP00000015321	ENSPREP00000025799	Myc associated factor X.	MAX dimerization protein 1.	0.920
ENSPREP00000015321	tfdp1	ENSPREP00000015321	ENSPREP00000014099	Myc associated factor X.	Transcription factor.	0.720
LOC103462700	mxd1	ENSPREP00000006807	ENSPREP00000025799	SIN3 transcription regulator family member Ab.	MAX dimerization protein 1.	0.768
LOC103462700	suds3	ENSPREP00000006807	ENSPREP00000006637	SIN3 transcription regulator family member Ab.	SDS3 homolog, SIN3A corepressor complex component.	0.909
LOC103476186	Slc31a2	ENSPREP00000017277	ENSPREP00000031365	RRM domain-containing protein.	Solute carrier family 31 member 2.	0.565
LOC103476186	mxd1	ENSPREP00000017277	ENSPREP00000025799	RRM domain-containing protein.	MAX dimerization protein 1.	0.477
MAX	ENSPREP00000015321	ENSPREP00000029247	ENSPREP00000015321	MYC associated factor X.	Myc associated factor X.	0.901
MAX	mxd1	ENSPREP00000029247	ENSPREP00000025799	MYC associated factor X.	MAX dimerization protein 1.	0.920
MAX	tfdp1	ENSPREP00000029247	ENSPREP00000014099	MYC associated factor X.	Transcription factor.	0.720
Slc31a2	LOC103476186	ENSPREP00000031365	ENSPREP00000017277	Solute carrier family 31 member 2.	RRM domain-containing protein.	0.565
Slc31a2	mxd1	ENSPREP00000031365	ENSPREP00000025799	Solute carrier family 31 member 2.	MAX dimerization protein 1.	0.479
add2	ENSPREP00000015321	ENSPREP00000026103	ENSPREP00000015321	Adducin 2 (beta).	Myc associated factor X.	0.550
add2	mxd1	ENSPREP00000026103	ENSPREP00000025799	Adducin 2 (beta).	MAX dimerization protein 1.	0.643
mxd1	ENSPREP00000015321	ENSPREP00000025799	ENSPREP00000015321	MAX dimerization protein 1.	Myc associated factor X.	0.920
mxd1	LOC103462700	ENSPREP00000025799	ENSPREP00000006807	MAX dimerization protein 1.	SIN3 transcription regulator family member Ab.	0.768
mxd1	LOC103476186	ENSPREP00000025799	ENSPREP00000017277	MAX dimerization protein 1.	RRM domain-containing protein.	0.477
mxd1	MAX	ENSPREP00000025799	ENSPREP00000029247	MAX dimerization protein 1.	MYC associated factor X.	0.920
mxd1	Slc31a2	ENSPREP00000025799	ENSPREP00000031365	MAX dimerization protein 1.	Solute carrier family 31 member 2.	0.479

page 1 of 2

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 34

2.03

4.81

2.24e-12

GO:0008360

Regulation of cell shape

8 of 49

1.88

4.25

3.90e-12

GO:0071555

Cell wall organization

8 of 59

1.79

3.91

8.16e-12

GO:0051301

Cell division

8 of 66

1.75

3.69

1.56e-11

GO:0007049

Cell cycle

7 of 63

1.71

3.15

1.41e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

5 of 17

2.13

3.14

3.12e-07

GO:0047480

UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0008766

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0043168

Anion binding

7 of 794

0.61

0.36

0.0471

GO:0043167

Ion binding

9 of 1444

0.46

0.29

0.0471

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25309529

(2014) L,L-diaminopimelate aminotransferase (DapL): a putative target for the development of narrow-spectrum antibacterial compounds.

2 of 4

2.36

1.07

0.0105

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1162

Cell shape

8 of 15

2.39

6.72

4.58e-15

CL:1164

Cell shape

7 of 10

2.51

6.47

7.15e-14

CL:1157

Mixed, incl. Cell shape, and Cell division site

9 of 33

2.1

5.82

4.58e-15

CL:1166

MurE/MurF, N-terminal, and UDP-glycosyltransferase activity

5 of 5

2.66

4.92

3.97e-10

CL:1638

Lysine biosynthesis

2 of 5

2.26

1.13

0.0079

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dsy00550

Peptidoglycan biosynthesis

8 of 29

2.1

5.5

6.05e-14

dsy00300

Lysine biosynthesis

5 of 22

2.02

3.27

6.80e-08

dsy01502

Vancomycin resistance

4 of 14

2.12

2.92

9.39e-07

dsy00471

D-Glutamine and D-glutamate metabolism

2 of 3

2.49

1.65

0.00089

dsy01100

Metabolic pathways

10 of 692

0.82

0.85

8.17e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

8 of 19

2.29

6.37

6.93e-15

KW-0961

Cell wall biogenesis/degradation

8 of 23

2.2

6.09

9.12e-15

KW-0132

Cell division

7 of 31

2.02

4.53

1.23e-11

KW-0131

Cell cycle

7 of 31

2.02

4.53

1.23e-11

KW-0436

Ligase

5 of 73

1.5

1.84

9.57e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

5 of 7

2.52

4.14

9.63e-09

PF08245

Mur ligase middle domain

5 of 9

2.41

4.01

1.21e-08

PF01225

Mur ligase family, catalytic domain

4 of 4

2.66

3.56

2.06e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

5 of 7

2.52

3.95

2.40e-08

IPR004101

Mur ligase, C-terminal

5 of 7

2.52

3.95

2.40e-08

IPR036565

Mur-like, catalytic domain superfamily

5 of 9

2.41

3.87

2.40e-08

IPR013221

Mur ligase, central

5 of 9

2.41

3.87

2.40e-08

IPR000713

Mur ligase, N-terminal catalytic domain

4 of 4

2.66

3.47

3.08e-07

(more ...)

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