LOC103472063 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

LOC103472063

Homeobox domain-containing protein. (432 aa)

Predicted Functional Partners:

lhx5

0.526

hhex

0.462

LOC103479586

0.456

pbx4

0.456

pbx3

0.456

pbx1

0.456

LOC103477587

0.456

dlx2

0.444

SRF

0.423

srf

0.423

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103472063	LOC103477587	ENSPREP00000025814	ENSPREP00000026946	Homeobox domain-containing protein.	Pre-B-cell leukemia homeobox 2.	0.456
LOC103472063	LOC103479586	ENSPREP00000025814	ENSPREP00000005103	Homeobox domain-containing protein.	Pre-B-cell leukemia homeobox 1a.	0.456
LOC103472063	SRF	ENSPREP00000025814	ENSPREP00000008765	Homeobox domain-containing protein.	Serum response factor.	0.423
LOC103472063	dlx2	ENSPREP00000025814	ENSPREP00000006391	Homeobox domain-containing protein.	Distal-less homeobox 2b.	0.444
LOC103472063	hhex	ENSPREP00000025814	ENSPREP00000004748	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.462
LOC103472063	lhx5	ENSPREP00000025814	ENSPREP00000027362	Homeobox domain-containing protein.	LIM homeobox 5.	0.526
LOC103472063	pbx1	ENSPREP00000025814	ENSPREP00000020357	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.456
LOC103472063	pbx3	ENSPREP00000025814	ENSPREP00000016794	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.456
LOC103472063	pbx4	ENSPREP00000025814	ENSPREP00000007689	Homeobox domain-containing protein.	Pre-B-cell leukemia transcription factor 4.	0.456
LOC103472063	srf	ENSPREP00000025814	ENSPREP00000012906	Homeobox domain-containing protein.	Serum response factor b.	0.423
LOC103477587	LOC103472063	ENSPREP00000026946	ENSPREP00000025814	Pre-B-cell leukemia homeobox 2.	Homeobox domain-containing protein.	0.456
LOC103479586	LOC103472063	ENSPREP00000005103	ENSPREP00000025814	Pre-B-cell leukemia homeobox 1a.	Homeobox domain-containing protein.	0.456
SRF	LOC103472063	ENSPREP00000008765	ENSPREP00000025814	Serum response factor.	Homeobox domain-containing protein.	0.423
dlx2	LOC103472063	ENSPREP00000006391	ENSPREP00000025814	Distal-less homeobox 2b.	Homeobox domain-containing protein.	0.444
hhex	LOC103472063	ENSPREP00000004748	ENSPREP00000025814	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.462
lhx5	LOC103472063	ENSPREP00000027362	ENSPREP00000025814	LIM homeobox 5.	Homeobox domain-containing protein.	0.526
pbx1	LOC103472063	ENSPREP00000020357	ENSPREP00000025814	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.456
pbx3	LOC103472063	ENSPREP00000016794	ENSPREP00000025814	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.456
pbx4	LOC103472063	ENSPREP00000007689	ENSPREP00000025814	Pre-B-cell leukemia transcription factor 4.	Homeobox domain-containing protein.	0.456
srf	LOC103472063	ENSPREP00000012906	ENSPREP00000025814	Serum response factor b.	Homeobox domain-containing protein.	0.423

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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