STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tp53bp1Tumor protein p53 binding protein, 1. (1579 aa)    
Predicted Functional Partners:
topbp1
DNA topoisomerase II binding protein 1.
    
 
 0.993
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.981
chek2
Checkpoint kinase 2.
    
 0.981
atm
Non-specific serine/threonine protein kinase.
    
 0.980
xrcc6
X-ray repair complementing defective repair in Chinese hamster cells 6.
    
 0.968
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
    
 
 0.958
paxip1
PAX interacting (with transcription-activation domain) protein 1.
    
 0.955
mdc1
Uncharacterized protein.
    
 0.955
ENSPREP00000031399
Ring finger protein 168.
    
 0.954
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.953
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.