LOC103479412 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103479412

T-cell acute lymphocytic leukemia 1. (394 aa)

Predicted Functional Partners:

lmo2

0.977

LOC103465371

0.824

ldb1

0.824

LOC103471855

0.799

TCF4

0.749

ENSPREP00000026287

0.749

tcf12

0.749

LOC103463652

0.747

spi1

0.742

LOC103460214

0.740

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000026287	LOC103460214	ENSPREP00000026287	ENSPREP00000017910	Uncharacterized protein.	Uncharacterized protein.	0.420
ENSPREP00000026287	LOC103465371	ENSPREP00000026287	ENSPREP00000000594	Uncharacterized protein.	LIM-domain binding 1b.	0.608
ENSPREP00000026287	LOC103471855	ENSPREP00000026287	ENSPREP00000010970	Uncharacterized protein.	LIM domain binding 2a.	0.571
ENSPREP00000026287	LOC103479412	ENSPREP00000026287	ENSPREP00000025934	Uncharacterized protein.	T-cell acute lymphocytic leukemia 1.	0.749
ENSPREP00000026287	ldb1	ENSPREP00000026287	ENSPREP00000030452	Uncharacterized protein.	LIM domain binding 1a.	0.608
ENSPREP00000026287	lmo2	ENSPREP00000026287	ENSPREP00000024054	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.742
LOC103460214	ENSPREP00000026287	ENSPREP00000017910	ENSPREP00000026287	Uncharacterized protein.	Uncharacterized protein.	0.420
LOC103460214	LOC103463652	ENSPREP00000017910	ENSPREP00000012692	Uncharacterized protein.	Transcription factor 3b.	0.420
LOC103460214	LOC103465371	ENSPREP00000017910	ENSPREP00000000594	Uncharacterized protein.	LIM-domain binding 1b.	0.591
LOC103460214	LOC103471855	ENSPREP00000017910	ENSPREP00000010970	Uncharacterized protein.	LIM domain binding 2a.	0.588
LOC103460214	LOC103479412	ENSPREP00000017910	ENSPREP00000025934	Uncharacterized protein.	T-cell acute lymphocytic leukemia 1.	0.740
LOC103460214	TCF4	ENSPREP00000017910	ENSPREP00000024390	Uncharacterized protein.	Transcription factor 4.	0.420
LOC103460214	ldb1	ENSPREP00000017910	ENSPREP00000030452	Uncharacterized protein.	LIM domain binding 1a.	0.591
LOC103460214	lmo2	ENSPREP00000017910	ENSPREP00000024054	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.933
LOC103460214	spi1	ENSPREP00000017910	ENSPREP00000033545	Uncharacterized protein.	Spi-1 proto-oncogene b.	0.537
LOC103460214	tcf12	ENSPREP00000017910	ENSPREP00000034338	Uncharacterized protein.	Transcription factor 12.	0.420
LOC103463652	LOC103460214	ENSPREP00000012692	ENSPREP00000017910	Transcription factor 3b.	Uncharacterized protein.	0.420
LOC103463652	LOC103465371	ENSPREP00000012692	ENSPREP00000000594	Transcription factor 3b.	LIM-domain binding 1b.	0.571
LOC103463652	LOC103471855	ENSPREP00000012692	ENSPREP00000010970	Transcription factor 3b.	LIM domain binding 2a.	0.571
LOC103463652	LOC103479412	ENSPREP00000012692	ENSPREP00000025934	Transcription factor 3b.	T-cell acute lymphocytic leukemia 1.	0.747

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.925

expected number of edges:

11

PPI enrichment p-value:

1.31e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006312

Mitotic recombination

6 of 20

2.79

6.33

8.67e-13

GO:0006310

DNA recombination

10 of 176

2.07

6.2

8.80e-17

GO:0000724

Double-strand break repair via homologous recombination

8 of 89

2.27

6.08

3.45e-14

GO:0045003

Double-strand break repair via synthesis-dependent strand annealing

5 of 7

3.17

6.04

8.13e-12

GO:0006302

Double-strand break repair

9 of 173

2.03

5.38

2.31e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140664

ATP-dependent DNA damage sensor activity

5 of 18

2.76

4.83

7.97e-10

GO:0008094

ATP-dependent activity, acting on DNA

6 of 107

2.07

3.8

3.86e-09

GO:0003697

Single-stranded DNA binding

4 of 87

1.98

2.16

3.39e-05

GO:0000150

DNA strand exchange activity

2 of 2

3.32

1.9

0.00038

GO:0003677

DNA binding

8 of 2428

0.84

0.71

0.00054

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033061

DNA recombinase mediator complex

5 of 6

3.24

6.17

5.15e-12

GO:0000781

Chromosome, telomeric region

4 of 56

2.17

2.67

4.39e-06

GO:0000228

Nuclear chromosome

5 of 149

1.84

2.48

2.44e-06

GO:0033065

Rad51C-XRCC3 complex

2 of 2

3.32

1.94

0.00032

GO:0032798

Swi5-Sfr1 complex

2 of 2

3.32

1.94

0.00032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35713948

(2022) Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex.

3 of 30

2.32

1.82

0.00037

PMID:24742317

(2014) Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana.

2 of 10

2.62

1.23

0.0057

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

1.02

0.0132

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7057

Homologous DNA Pairing and Strand Exchange, and DNA replication factor A complex

6 of 22

2.75

5.95

4.36e-12

CL:7085

DNA recombination and repair protein Rad51-like, C-terminal

4 of 6

3.14

4.5

6.07e-09

CL:35651

Mixed, incl. Swi5-Sfr1 complex, and TRAM1-like protein

3 of 7

2.95

2.88

5.51e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03440

Homologous recombination

2 of 27

2.19

0.99

0.0141

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5693579

Homologous DNA Pairing and Strand Exchange

4 of 26

2.5

3.1

1.31e-06

MAP-5693568

Resolution of D-loop Structures through Holliday Junction Intermediates

4 of 30

2.44

3.07

1.31e-06

MAP-5693537

Resolution of D-Loop Structures

4 of 30

2.44

3.07

1.31e-06

MAP-5685942

HDR through Homologous Recombination (HRR)

4 of 64

2.11

2.59

5.52e-06

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

5 of 140

1.87

2.56

1.78e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033061

DNA recombinase mediator complex

6 of 7

3.25

7.73

6.11e-15

GOCC:0000228

Nuclear chromosome

5 of 207

1.7

1.99

2.21e-05

GOCC:0033065

Rad51C-XRCC3 complex

2 of 2

3.32

1.89

0.00039

GOCC:0032798

Swi5-Sfr1 complex

2 of 2

3.32

1.89

0.00039

GOCC:0033063

Rad51B-Rad51C-Rad51D-XRCC2 complex

2 of 3

3.14

1.86

0.00044

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020588

DNA recombination and repair protein RecA-like, ATP-binding domain

5 of 6

3.24

5.77

2.90e-11

IPR013632

DNA recombination and repair protein Rad51-like, C-terminal

5 of 6

3.24

5.77

2.90e-11

IPR016467

DNA recombination and repair protein, RecA-like

2 of 2

3.32

1.4

0.0030

IPR010995

DNA repair Rad51/transcription factor NusA, alpha-helical

2 of 2

3.32

1.4

0.0030

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 151

1.74

1.54

0.00050

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 7

2.77

1.4

0.0029

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