Trio protein (Poecilia reticulata) - STRING interaction network

Nodes:

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white nodes:
second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

Trio

Trio Rho guanine nucleotide exchange factor a. (1516 aa)

Predicted Functional Partners:

ENSPREP00000023655

0.901

dapk3

0.773

dapk2

0.710

CDC42

0.651

LOC103465423

0.651

stk17b

0.633

RHOG

0.626

LOC103470451

0.626

rhobtb2

0.626

ENSPREP00000010679

0.626

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSPREP00000010679	ENSPREP00000005959	ENSPREP00000010679	Cell division cycle 42.	Ras homolog gene family, member Gd.	0.444
CDC42	ENSPREP00000023655	ENSPREP00000005959	ENSPREP00000023655	Cell division cycle 42.	Protein kinase domain-containing protein.	0.599
CDC42	RHOG	ENSPREP00000005959	ENSPREP00000001999	Cell division cycle 42.	Ras homolog family member G.	0.446
CDC42	Trio	ENSPREP00000005959	ENSPREP00000026237	Cell division cycle 42.	Trio Rho guanine nucleotide exchange factor a.	0.651
ENSPREP00000010679	CDC42	ENSPREP00000010679	ENSPREP00000005959	Ras homolog gene family, member Gd.	Cell division cycle 42.	0.444
ENSPREP00000010679	ENSPREP00000023655	ENSPREP00000010679	ENSPREP00000023655	Ras homolog gene family, member Gd.	Protein kinase domain-containing protein.	0.599
ENSPREP00000010679	LOC103465423	ENSPREP00000010679	ENSPREP00000026666	Ras homolog gene family, member Gd.	Cell division cycle 42.	0.444
ENSPREP00000010679	RHOG	ENSPREP00000010679	ENSPREP00000001999	Ras homolog gene family, member Gd.	Ras homolog family member G.	0.901
ENSPREP00000010679	Trio	ENSPREP00000010679	ENSPREP00000026237	Ras homolog gene family, member Gd.	Trio Rho guanine nucleotide exchange factor a.	0.626
ENSPREP00000023655	CDC42	ENSPREP00000023655	ENSPREP00000005959	Protein kinase domain-containing protein.	Cell division cycle 42.	0.599
ENSPREP00000023655	ENSPREP00000010679	ENSPREP00000023655	ENSPREP00000010679	Protein kinase domain-containing protein.	Ras homolog gene family, member Gd.	0.599
ENSPREP00000023655	LOC103465423	ENSPREP00000023655	ENSPREP00000026666	Protein kinase domain-containing protein.	Cell division cycle 42.	0.599
ENSPREP00000023655	LOC103470451	ENSPREP00000023655	ENSPREP00000006874	Protein kinase domain-containing protein.	Rho related BTB domain containing 4.	0.599
ENSPREP00000023655	RHOG	ENSPREP00000023655	ENSPREP00000001999	Protein kinase domain-containing protein.	Ras homolog family member G.	0.599
ENSPREP00000023655	Trio	ENSPREP00000023655	ENSPREP00000026237	Protein kinase domain-containing protein.	Trio Rho guanine nucleotide exchange factor a.	0.901
ENSPREP00000023655	rhobtb2	ENSPREP00000023655	ENSPREP00000009484	Protein kinase domain-containing protein.	Rho related BTB domain containing 2a.	0.599
LOC103465423	ENSPREP00000010679	ENSPREP00000026666	ENSPREP00000010679	Cell division cycle 42.	Ras homolog gene family, member Gd.	0.444
LOC103465423	ENSPREP00000023655	ENSPREP00000026666	ENSPREP00000023655	Cell division cycle 42.	Protein kinase domain-containing protein.	0.599
LOC103465423	RHOG	ENSPREP00000026666	ENSPREP00000001999	Cell division cycle 42.	Ras homolog family member G.	0.446
LOC103465423	Trio	ENSPREP00000026666	ENSPREP00000026237	Cell division cycle 42.	Trio Rho guanine nucleotide exchange factor a.	0.651

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

16

PPI enrichment p-value:

7.99e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 5

2.31

1.56

0.0012

GO:0051276

Chromosome organization

4 of 27

1.7

1.37

0.0012

GO:0006259

DNA metabolic process

5 of 139

1.09

0.74

0.0085

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003916

DNA topoisomerase activity

3 of 5

2.31

1.69

0.00066

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

2 of 4

2.23

0.93

0.0186

GO:0140097

Catalytic activity, acting on DNA

4 of 76

1.25

0.74

0.0179

GO:0003677

DNA binding

6 of 280

0.86

0.55

0.0179

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4965

Mixed, incl. Chromosome condensation, and SPFH domain / Band 7 family

5 of 5

2.53

4.28

5.25e-09

CL:4962

Mostly uncharacterized, incl. Virulence factor BrkB, and Chromosome condensation

6 of 12

2.23

4.17

1.84e-09

CL:505

Mixed, incl. 3-5 exonuclease, and RecQ zinc-binding

2 of 5

2.13

0.96

0.0158

CL:500

Homologous recombination, and ATP-dependent activity, acting on DNA

3 of 35

1.47

0.84

0.0158

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

2 of 4

2.23

0.89

0.0231

KW-0175

Coiled coil

7 of 515

0.67

0.42

0.0231

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006171

TOPRIM domain

3 of 5

2.31

1.52

0.0014

IPR018522

DNA topoisomerase, type IIA, conserved site

2 of 2

2.53

0.83

0.0310

IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal

2 of 2

2.53

0.83

0.0310

IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2

2 of 2

2.53

0.83

0.0310

IPR001241

DNA topoisomerase, type IIA

2 of 2

2.53

0.83

0.0310

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00433

TopoisomeraseII

2 of 2

2.53

1.26

0.0050

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