rpl14 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

rpl14

Ribosomal protein L14. (138 aa)

Predicted Functional Partners:

rps3a

0.999

rpl35a

0.999

rplp0

0.999

rps5

0.999

rpl28

0.999

rpl37

0.999

rps25

0.999

RPL27A

0.999

rps6

0.999

rps13

0.999

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RPL27A	rpl14	ENSPREP00000006045	ENSPREP00000026385	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein L14.	0.999
RPL27A	rpl28	ENSPREP00000006045	ENSPREP00000002767	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein L28.	0.999
RPL27A	rpl35a	ENSPREP00000006045	ENSPREP00000000811	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein L35a.	0.999
RPL27A	rpl37	ENSPREP00000006045	ENSPREP00000002894	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein L37; Binds to the 23S rRNA.	0.999
RPL27A	rplp0	ENSPREP00000006045	ENSPREP00000000853	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein, large, P0.	0.999
RPL27A	rps13	ENSPREP00000006045	ENSPREP00000006834	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.999
RPL27A	rps25	ENSPREP00000006045	ENSPREP00000005355	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.999
RPL27A	rps3a	ENSPREP00000006045	ENSPREP00000000144	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
RPL27A	rps5	ENSPREP00000006045	ENSPREP00000002609	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.999
RPL27A	rps6	ENSPREP00000006045	ENSPREP00000006473	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.999
rpl14	RPL27A	ENSPREP00000026385	ENSPREP00000006045	Ribosomal protein L14.	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	0.999
rpl14	rpl28	ENSPREP00000026385	ENSPREP00000002767	Ribosomal protein L14.	Ribosomal protein L28.	0.999
rpl14	rpl35a	ENSPREP00000026385	ENSPREP00000000811	Ribosomal protein L14.	Ribosomal protein L35a.	0.999
rpl14	rpl37	ENSPREP00000026385	ENSPREP00000002894	Ribosomal protein L14.	Ribosomal protein L37; Binds to the 23S rRNA.	0.999
rpl14	rplp0	ENSPREP00000026385	ENSPREP00000000853	Ribosomal protein L14.	Ribosomal protein, large, P0.	0.999
rpl14	rps13	ENSPREP00000026385	ENSPREP00000006834	Ribosomal protein L14.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.999
rpl14	rps25	ENSPREP00000026385	ENSPREP00000005355	Ribosomal protein L14.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.999
rpl14	rps3a	ENSPREP00000026385	ENSPREP00000000144	Ribosomal protein L14.	40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
rpl14	rps5	ENSPREP00000026385	ENSPREP00000002609	Ribosomal protein L14.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.999
rpl14	rps6	ENSPREP00000026385	ENSPREP00000006473	Ribosomal protein L14.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.999

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

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