ENSPREP00000026545 protein (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ENSPREP00000026545

Uncharacterized protein. (90 aa)

Predicted Functional Partners:

fga

0.822

fgb

0.801

LOC103459868

0.767

serpinf2

0.767

serpinc1

0.737

serpind1

0.707

LOC103479052

0.703

f2

0.696

fgg

0.692

ambp

0.626

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000026545	LOC103459868	ENSPREP00000026545	ENSPREP00000003297	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.767
ENSPREP00000026545	LOC103479052	ENSPREP00000026545	ENSPREP00000008706	Uncharacterized protein.	Alpha-2-HS-glycoprotein 2.	0.703
ENSPREP00000026545	ambp	ENSPREP00000026545	ENSPREP00000012094	Uncharacterized protein.	Alpha-1-microglobulin/bikunin precursor.	0.626
ENSPREP00000026545	f2	ENSPREP00000026545	ENSPREP00000016717	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.696
ENSPREP00000026545	fga	ENSPREP00000026545	ENSPREP00000011903	Uncharacterized protein.	Fibrinogen alpha chain.	0.822
ENSPREP00000026545	fgb	ENSPREP00000026545	ENSPREP00000011828	Uncharacterized protein.	Fibrinogen beta chain.	0.801
ENSPREP00000026545	fgg	ENSPREP00000026545	ENSPREP00000000072	Uncharacterized protein.	Fibrinogen gamma chain.	0.692
ENSPREP00000026545	serpinc1	ENSPREP00000026545	ENSPREP00000001582	Uncharacterized protein.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.737
ENSPREP00000026545	serpind1	ENSPREP00000026545	ENSPREP00000015961	Uncharacterized protein.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.707
ENSPREP00000026545	serpinf2	ENSPREP00000026545	ENSPREP00000015036	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.767
LOC103459868	ENSPREP00000026545	ENSPREP00000003297	ENSPREP00000026545	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.767
LOC103459868	LOC103479052	ENSPREP00000003297	ENSPREP00000008706	SERPIN domain-containing protein; Belongs to the serpin family.	Alpha-2-HS-glycoprotein 2.	0.500
LOC103459868	ambp	ENSPREP00000003297	ENSPREP00000012094	SERPIN domain-containing protein; Belongs to the serpin family.	Alpha-1-microglobulin/bikunin precursor.	0.495
LOC103459868	f2	ENSPREP00000003297	ENSPREP00000016717	SERPIN domain-containing protein; Belongs to the serpin family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.721
LOC103459868	fga	ENSPREP00000003297	ENSPREP00000011903	SERPIN domain-containing protein; Belongs to the serpin family.	Fibrinogen alpha chain.	0.675
LOC103459868	fgb	ENSPREP00000003297	ENSPREP00000011828	SERPIN domain-containing protein; Belongs to the serpin family.	Fibrinogen beta chain.	0.480
LOC103459868	fgg	ENSPREP00000003297	ENSPREP00000000072	SERPIN domain-containing protein; Belongs to the serpin family.	Fibrinogen gamma chain.	0.516
LOC103459868	serpinc1	ENSPREP00000003297	ENSPREP00000001582	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.641
LOC103459868	serpind1	ENSPREP00000003297	ENSPREP00000015961	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.476
LOC103479052	ENSPREP00000026545	ENSPREP00000008706	ENSPREP00000026545	Alpha-2-HS-glycoprotein 2.	Uncharacterized protein.	0.703

page 1 of 6

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

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