sos2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

sos2

Son of sevenless homolog 2 (Drosophila). (645 aa)

Predicted Functional Partners:

grb2

0.997

LOC103469088

0.965

kras

0.965

hras

0.965

EGFR

0.961

egfr

0.961

rras2

0.948

LOC103468146

0.947

mras

0.947

LOC103469672

0.946

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	LOC103469088	ENSPREP00000015371	ENSPREP00000020359	Receptor protein-tyrosine kinase.	Zgc:55558.	0.521
EGFR	egfr	ENSPREP00000015371	ENSPREP00000025280	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.902
EGFR	grb2	ENSPREP00000015371	ENSPREP00000022510	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2b.	0.981
EGFR	hras	ENSPREP00000015371	ENSPREP00000028573	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase a.	0.511
EGFR	kras	ENSPREP00000015371	ENSPREP00000027060	Receptor protein-tyrosine kinase.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.713
EGFR	sos2	ENSPREP00000015371	ENSPREP00000026590	Receptor protein-tyrosine kinase.	Son of sevenless homolog 2 (Drosophila).	0.961
LOC103468146	grb2	ENSPREP00000009362	ENSPREP00000022510	RAS related.	Growth factor receptor-bound protein 2b.	0.524
LOC103468146	sos2	ENSPREP00000009362	ENSPREP00000026590	RAS related.	Son of sevenless homolog 2 (Drosophila).	0.947
LOC103469088	EGFR	ENSPREP00000020359	ENSPREP00000015371	Zgc:55558.	Receptor protein-tyrosine kinase.	0.521
LOC103469088	egfr	ENSPREP00000020359	ENSPREP00000025280	Zgc:55558.	Receptor protein-tyrosine kinase.	0.521
LOC103469088	grb2	ENSPREP00000020359	ENSPREP00000022510	Zgc:55558.	Growth factor receptor-bound protein 2b.	0.667
LOC103469088	hras	ENSPREP00000020359	ENSPREP00000028573	Zgc:55558.	HRas proto-oncogene, GTPase a.	0.910
LOC103469088	kras	ENSPREP00000020359	ENSPREP00000027060	Zgc:55558.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.901
LOC103469088	sos2	ENSPREP00000020359	ENSPREP00000026590	Zgc:55558.	Son of sevenless homolog 2 (Drosophila).	0.965
LOC103469672	grb2	ENSPREP00000001007	ENSPREP00000022510	Fibroblast growth factor receptor.	Growth factor receptor-bound protein 2b.	0.920
LOC103469672	sos2	ENSPREP00000001007	ENSPREP00000026590	Fibroblast growth factor receptor.	Son of sevenless homolog 2 (Drosophila).	0.946
egfr	EGFR	ENSPREP00000025280	ENSPREP00000015371	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.902
egfr	LOC103469088	ENSPREP00000025280	ENSPREP00000020359	Receptor protein-tyrosine kinase.	Zgc:55558.	0.521
egfr	grb2	ENSPREP00000025280	ENSPREP00000022510	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2b.	0.981
egfr	hras	ENSPREP00000025280	ENSPREP00000028573	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase a.	0.511

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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