ENSPREP00000026853 protein (Poecilia reticulata)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Score

ENSPREP00000026853

Tubulin tyrosine ligase-like family, member 2. (538 aa)

Predicted Functional Partners:

dcp2

0.619

dcp1a

0.548

dcp1b

0.548

fam120c

0.535

LOC103478983

0.471

suco

0.471

yjefn3

0.453

naxe

0.453

edc3

0.453

tpgs2

0.445

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000026853	LOC103478983	ENSPREP00000026853	ENSPREP00000005447	Tubulin tyrosine ligase-like family, member 2.	SUN domain-containing protein.	0.471
ENSPREP00000026853	dcp1a	ENSPREP00000026853	ENSPREP00000000963	Tubulin tyrosine ligase-like family, member 2.	Decapping mRNA 1A.	0.548
ENSPREP00000026853	dcp1b	ENSPREP00000026853	ENSPREP00000006140	Tubulin tyrosine ligase-like family, member 2.	Decapping mRNA 1B.	0.548
ENSPREP00000026853	dcp2	ENSPREP00000026853	ENSPREP00000018031	Tubulin tyrosine ligase-like family, member 2.	Decapping mRNA 2.	0.619
ENSPREP00000026853	edc3	ENSPREP00000026853	ENSPREP00000023739	Tubulin tyrosine ligase-like family, member 2.	Enhancer of mRNA decapping 3 homolog (S. cerevisiae).	0.453
ENSPREP00000026853	fam120c	ENSPREP00000026853	ENSPREP00000030245	Tubulin tyrosine ligase-like family, member 2.	Family with sequence similarity 120C.	0.535
ENSPREP00000026853	naxe	ENSPREP00000026853	ENSPREP00000013574	Tubulin tyrosine ligase-like family, member 2.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.	0.453
ENSPREP00000026853	suco	ENSPREP00000026853	ENSPREP00000031490	Tubulin tyrosine ligase-like family, member 2.	SUN domain containing ossification factor.	0.471
ENSPREP00000026853	tpgs2	ENSPREP00000026853	ENSPREP00000031247	Tubulin tyrosine ligase-like family, member 2.	Tubulin polyglutamylase complex subunit 2.	0.445
ENSPREP00000026853	yjefn3	ENSPREP00000026853	ENSPREP00000010578	Tubulin tyrosine ligase-like family, member 2.	YjeF N-terminal domain containing 3.	0.453
LOC103478983	ENSPREP00000026853	ENSPREP00000005447	ENSPREP00000026853	SUN domain-containing protein.	Tubulin tyrosine ligase-like family, member 2.	0.471
dcp1a	ENSPREP00000026853	ENSPREP00000000963	ENSPREP00000026853	Decapping mRNA 1A.	Tubulin tyrosine ligase-like family, member 2.	0.548
dcp1a	dcp1b	ENSPREP00000000963	ENSPREP00000006140	Decapping mRNA 1A.	Decapping mRNA 1B.	0.992
dcp1a	dcp2	ENSPREP00000000963	ENSPREP00000018031	Decapping mRNA 1A.	Decapping mRNA 2.	0.983
dcp1a	edc3	ENSPREP00000000963	ENSPREP00000023739	Decapping mRNA 1A.	Enhancer of mRNA decapping 3 homolog (S. cerevisiae).	0.984
dcp1a	naxe	ENSPREP00000000963	ENSPREP00000013574	Decapping mRNA 1A.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.	0.882
dcp1a	yjefn3	ENSPREP00000000963	ENSPREP00000010578	Decapping mRNA 1A.	YjeF N-terminal domain containing 3.	0.882
dcp1b	ENSPREP00000026853	ENSPREP00000006140	ENSPREP00000026853	Decapping mRNA 1B.	Tubulin tyrosine ligase-like family, member 2.	0.548
dcp1b	dcp1a	ENSPREP00000006140	ENSPREP00000000963	Decapping mRNA 1B.	Decapping mRNA 1A.	0.992
dcp1b	dcp2	ENSPREP00000006140	ENSPREP00000018031	Decapping mRNA 1B.	Decapping mRNA 2.	0.977

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.876

expected number of edges:

12

PPI enrichment p-value:

0.000499

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010608

Post-transcriptional regulation of gene expression

7 of 445

1.51

1.99

2.82e-06

GO:0006378

mRNA polyadenylation

3 of 21

2.47

1.92

0.00027

GO:0006417

Regulation of translation

6 of 377

1.52

1.72

3.71e-05

GO:0043489

RNA stabilization

3 of 44

2.15

1.59

0.00090

GO:0017148

Negative regulation of translation

4 of 139

1.78

1.55

0.00054

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1169

1.09

0.96

0.00069

GO:0004652

Polynucleotide adenylyltransferase activity

2 of 15

2.44

0.85

0.0281

GO:1901363

Heterocyclic compound binding

10 of 6300

0.52

0.34

0.0281

GO:0097159

Organic cyclic compound binding

10 of 6378

0.51

0.34

0.0281

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

3 of 15

2.62

2.3

5.53e-05

PMID:34263725

(2021) A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma.

2 of 21

2.3

0.9

0.0218

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2940

Mixed, incl. Deadenylation-dependent mRNA decay, and Anti-proliferative protein

5 of 90

2.06

2.7

2.52e-06

CL:11094

mRNA cleavage and polyadenylation specificity factor complex

2 of 7

2.77

0.95

0.0189

CL:3058

mRNA decay by 5 to 3 exoribonuclease, and Scd6-like Sm domain

2 of 15

2.44

0.79

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04914

Progesterone-mediated oocyte maturation

3 of 88

1.85

1.38

0.0016

pret04114

Oocyte meiosis

3 of 111

1.75

1.34

0.0016

pret03018

RNA degradation

2 of 69

1.78

0.8

0.0284

pret03015

mRNA surveillance pathway

2 of 76

1.74

0.79

0.0284

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8953854

Metabolism of RNA

7 of 895

1.21

1.26

6.94e-05

MAP-429914

Deadenylation-dependent mRNA decay

3 of 74

1.93

1.18

0.0049

MAP-6804114

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

2 of 13

2.5

1.05

0.0122

MAP-77595

Processing of Intronless Pre-mRNAs

2 of 21

2.3

0.9

0.0220

MAP-75067

Processing of Capped Intronless Pre-mRNA

2 of 24

2.24

0.89

0.0226

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