pacs2 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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gene co-occurrence

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protein homology

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pacs2

Phosphofurin acidic cluster sorting protein 2. (882 aa)

Predicted Functional Partners:

LOC103482259

0.588

WDR37

0.588

UBE2O

0.545

mrpl38

0.473

hspa9

0.468

ak1

0.410

ak5

0.410

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103482259	pacs2	ENSPREP00000009787	ENSPREP00000026891	WD repeat domain 37.	Phosphofurin acidic cluster sorting protein 2.	0.588
UBE2O	ak1	ENSPREP00000029489	ENSPREP00000024393	Ubiquitin conjugating enzyme E2 O.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.414
UBE2O	ak5	ENSPREP00000029489	ENSPREP00000026744	Ubiquitin conjugating enzyme E2 O.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.414
UBE2O	pacs2	ENSPREP00000029489	ENSPREP00000026891	Ubiquitin conjugating enzyme E2 O.	Phosphofurin acidic cluster sorting protein 2.	0.545
WDR37	pacs2	ENSPREP00000029404	ENSPREP00000026891	WD repeat domain 37.	Phosphofurin acidic cluster sorting protein 2.	0.588
ak1	UBE2O	ENSPREP00000024393	ENSPREP00000029489	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Ubiquitin conjugating enzyme E2 O.	0.414
ak1	ak5	ENSPREP00000024393	ENSPREP00000026744	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.902
ak1	pacs2	ENSPREP00000024393	ENSPREP00000026891	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Phosphofurin acidic cluster sorting protein 2.	0.410
ak5	UBE2O	ENSPREP00000026744	ENSPREP00000029489	Adenylate kinase 5; Belongs to the adenylate kinase family.	Ubiquitin conjugating enzyme E2 O.	0.414
ak5	ak1	ENSPREP00000026744	ENSPREP00000024393	Adenylate kinase 5; Belongs to the adenylate kinase family.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.902
ak5	pacs2	ENSPREP00000026744	ENSPREP00000026891	Adenylate kinase 5; Belongs to the adenylate kinase family.	Phosphofurin acidic cluster sorting protein 2.	0.410
hspa9	pacs2	ENSPREP00000001232	ENSPREP00000026891	Heat shock protein 9; Belongs to the heat shock protein 70 family.	Phosphofurin acidic cluster sorting protein 2.	0.468
mrpl38	pacs2	ENSPREP00000028443	ENSPREP00000026891	Mitochondrial ribosomal protein L38.	Phosphofurin acidic cluster sorting protein 2.	0.473
pacs2	LOC103482259	ENSPREP00000026891	ENSPREP00000009787	Phosphofurin acidic cluster sorting protein 2.	WD repeat domain 37.	0.588
pacs2	UBE2O	ENSPREP00000026891	ENSPREP00000029489	Phosphofurin acidic cluster sorting protein 2.	Ubiquitin conjugating enzyme E2 O.	0.545
pacs2	WDR37	ENSPREP00000026891	ENSPREP00000029404	Phosphofurin acidic cluster sorting protein 2.	WD repeat domain 37.	0.588
pacs2	ak1	ENSPREP00000026891	ENSPREP00000024393	Phosphofurin acidic cluster sorting protein 2.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.410
pacs2	ak5	ENSPREP00000026891	ENSPREP00000026744	Phosphofurin acidic cluster sorting protein 2.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.410
pacs2	hspa9	ENSPREP00000026891	ENSPREP00000001232	Phosphofurin acidic cluster sorting protein 2.	Heat shock protein 9; Belongs to the heat shock protein 70 family.	0.468
pacs2	mrpl38	ENSPREP00000026891	ENSPREP00000028443	Phosphofurin acidic cluster sorting protein 2.	Mitochondrial ribosomal protein L38.	0.473

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.564

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

5 of 13

2.93

5.3

1.41e-10

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

4 of 7

3.11

4.74

2.06e-09

GO:0019752

Carboxylic acid metabolic process

8 of 477

1.57

2.75

2.06e-09

GO:0045454

Cell redox homeostasis

3 of 20

2.53

2.65

1.03e-05

GO:0009063

Cellular amino acid catabolic process

3 of 42

2.2

2.15

6.41e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004148

Dihydrolipoyl dehydrogenase activity

3 of 6

3.05

2.81

7.67e-06

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 8

2.92

2.8

7.67e-06

GO:0016746

Acyltransferase activity

5 of 166

1.83

2.29

7.67e-06

GO:0003863

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

2 of 2

3.35

2.04

0.00021

GO:0016491

Oxidoreductase activity

6 of 680

1.29

1.4

5.20e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

10 of 45

2.7

11.15

9.60e-24

GO:0045240

Dihydrolipoyl dehydrogenase complex

6 of 12

3.05

7.52

9.24e-15

GO:0045254

Pyruvate dehydrogenase complex

4 of 5

3.25

5.34

1.81e-10

GO:0005759

Mitochondrial matrix

6 of 76

2.25

4.87

3.83e-11

GO:0045252

Oxoglutarate dehydrogenase complex

4 of 10

2.95

4.8

1.30e-09

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23006831

(2012) Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation.

3 of 3

3.35

2.98

4.18e-06

PMID:34702846

(2021) MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes.

3 of 4

3.22

2.97

4.18e-06

PMID:30619403

(2018) Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana.

3 of 5

3.13

2.96

4.18e-06

PMID:31266864

(2019) DayNight Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolae.

3 of 8

2.92

2.77

8.61e-06

PMID:33413098

(2021) Nutrient-imbalanced conditions shift the interplay between zooplankton and gut microbiota.

3 of 9

2.87

2.75

9.18e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14150

Dihydrolipoyl dehydrogenase complex, and acetyl-CoA biosynthetic process from pyruvate

11 of 19

3.11

15.36

2.61e-30

CL:14153

Citrate cycle (TCA cycle)

8 of 12

3.17

11.04

2.13e-21

CL:14155

acetyl-CoA biosynthetic process from pyruvate, and Dihydrolipoyl dehydrogenase activity

5 of 6

3.27

6.6

8.43e-13

CL:14167

Thiamine pyrophosphate binding, and Succinyltransferase activity

2 of 5

2.95

1.66

0.0010

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gtt00020

Citrate cycle (TCA cycle)

8 of 22

2.91

10.09

3.15e-20

gtt00620

Pyruvate metabolism

7 of 42

2.57

7.41

9.44e-16

gtt00640

Propanoate metabolism

6 of 21

2.8

7.37

6.87e-15

gtt00280

Valine, leucine and isoleucine degradation

6 of 26

2.71

7.05

1.84e-14

gtt00010

Glycolysis / Gluconeogenesis

7 of 55

2.45

6.94

3.00e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389661

Glyoxylate metabolism and glycine degradation

11 of 42

2.77

13.04

1.33e-27

MAP-70268

Pyruvate metabolism

7 of 26

2.78

8.0

2.81e-16

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

8 of 53

2.53

7.88

4.20e-17

MAP-71291

Metabolism of amino acids and derivatives

11 of 248

2.0

6.55

6.19e-20

MAP-70895

Branched-chain amino acid catabolism

6 of 28

2.68

6.44

2.90e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 37

2.63

7.06

9.50e-15

GOCC:0045254

Pyruvate dehydrogenase complex

4 of 7

3.11

4.66

2.90e-09

GOCC:0045240

Dihydrolipoyl dehydrogenase complex

3 of 6

3.05

3.26

1.13e-06

GOCC:0005947

Mitochondrial alpha-ketoglutarate dehydrogenase complex

2 of 2

3.35

2.2

0.00011

GOCC:0005759

Mitochondrial matrix

3 of 56

2.08

1.91

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

3 of 4

3.22

3.46

5.20e-07

KW-0012

Acyltransferase

3 of 35

2.28

2.27

4.15e-05

KW-0560

Oxidoreductase

4 of 136

1.82

2.03

3.60e-05

KW-0786

Thiamine pyrophosphate

2 of 5

2.95

2.03

0.00021

KW-0676

Redox-active center

2 of 20

2.35

1.46

0.0019

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

5 of 5

3.35

6.4

2.19e-12

PF02817

e3 binding domain

3 of 3

3.35

3.34

9.36e-07

PF00364

Biotin-requiring enzyme

3 of 9

2.87

2.82

6.86e-06

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 14

2.68

2.59

1.59e-05

PF02780

Transketolase, C-terminal domain

2 of 7

2.8

1.51

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001078

2-oxoacid dehydrogenase acyltransferase, catalytic domain

5 of 5

3.35

6.17

5.90e-12

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

5 of 15

2.87

5.21

1.81e-10

IPR036625

E3-binding domain superfamily

3 of 3

3.35

3.19

1.69e-06

IPR004167

Peripheral subunit-binding domain

3 of 3

3.35

3.19

1.69e-06

IPR045257

Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component

3 of 4

3.22

3.17

1.77e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 8

2.75

1.39

0.0030

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