ENSPREP00000027744 protein (Poecilia reticulata)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ENSPREP00000027744

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (328 aa)

Predicted Functional Partners:

srsf10

0.776

LOC103480306

0.770

LOC103464518

0.764

tardbp

0.764

srsf2

0.730

LOC103473466

0.724

hnrnpk

0.724

taf13

0.722

polr2b

0.715

Taf12

0.706

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000027744	LOC103464518	ENSPREP00000027744	ENSPREP00000006319	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAR DNA binding protein.	0.764
ENSPREP00000027744	LOC103473466	ENSPREP00000027744	ENSPREP00000004020	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Heterogeneous nuclear ribonucleoprotein K, like.	0.724
ENSPREP00000027744	LOC103480306	ENSPREP00000027744	ENSPREP00000011655	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	RRM domain-containing protein.	0.770
ENSPREP00000027744	Taf12	ENSPREP00000027744	ENSPREP00000007202	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.706
ENSPREP00000027744	hnrnpk	ENSPREP00000027744	ENSPREP00000028098	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Heterogeneous nuclear ribonucleoprotein K.	0.724
ENSPREP00000027744	polr2b	ENSPREP00000027744	ENSPREP00000016486	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.715
ENSPREP00000027744	srsf10	ENSPREP00000027744	ENSPREP00000012355	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	RRM domain-containing protein.	0.776
ENSPREP00000027744	srsf2	ENSPREP00000027744	ENSPREP00000005249	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Serine and arginine rich splicing factor 2a.	0.730
ENSPREP00000027744	taf13	ENSPREP00000027744	ENSPREP00000005745	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TATA-box binding protein associated factor 13.	0.722
ENSPREP00000027744	tardbp	ENSPREP00000027744	ENSPREP00000023804	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAR DNA binding protein, like.	0.764
LOC103464518	ENSPREP00000027744	ENSPREP00000006319	ENSPREP00000027744	TAR DNA binding protein.	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.764
LOC103464518	LOC103473466	ENSPREP00000006319	ENSPREP00000004020	TAR DNA binding protein.	Heterogeneous nuclear ribonucleoprotein K, like.	0.707
LOC103464518	LOC103480306	ENSPREP00000006319	ENSPREP00000011655	TAR DNA binding protein.	RRM domain-containing protein.	0.713
LOC103464518	hnrnpk	ENSPREP00000006319	ENSPREP00000028098	TAR DNA binding protein.	Heterogeneous nuclear ribonucleoprotein K.	0.707
LOC103464518	polr2b	ENSPREP00000006319	ENSPREP00000016486	TAR DNA binding protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.512
LOC103464518	srsf2	ENSPREP00000006319	ENSPREP00000005249	TAR DNA binding protein.	Serine and arginine rich splicing factor 2a.	0.702
LOC103464518	tardbp	ENSPREP00000006319	ENSPREP00000023804	TAR DNA binding protein.	TAR DNA binding protein, like.	0.901
LOC103473466	ENSPREP00000027744	ENSPREP00000004020	ENSPREP00000027744	Heterogeneous nuclear ribonucleoprotein K, like.	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.724
LOC103473466	LOC103464518	ENSPREP00000004020	ENSPREP00000006319	Heterogeneous nuclear ribonucleoprotein K, like.	TAR DNA binding protein.	0.707
LOC103473466	LOC103480306	ENSPREP00000004020	ENSPREP00000011655	Heterogeneous nuclear ribonucleoprotein K, like.	RRM domain-containing protein.	0.983

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

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