ENSPREP00000027813 protein (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSPREP00000027813

HTH_Tnp_Tc3_2 domain-containing protein. (345 aa)

Predicted Functional Partners:

grap2

0.618

ENSPREP00000005841

0.549

ENSPREP00000029144

0.529

grb2

0.523

gak

0.445

nck2

0.425

nck1

0.425

ubxn7

0.415

ift81

0.400

ENSPREP00000027150

0.400

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005841	ENSPREP00000027813	ENSPREP00000005841	ENSPREP00000027813	DDE_3 domain-containing protein.	HTH_Tnp_Tc3_2 domain-containing protein.	0.549
ENSPREP00000027150	ENSPREP00000027813	ENSPREP00000027150	ENSPREP00000027813	Uncharacterized protein.	HTH_Tnp_Tc3_2 domain-containing protein.	0.400
ENSPREP00000027813	ENSPREP00000005841	ENSPREP00000027813	ENSPREP00000005841	HTH_Tnp_Tc3_2 domain-containing protein.	DDE_3 domain-containing protein.	0.549
ENSPREP00000027813	ENSPREP00000027150	ENSPREP00000027813	ENSPREP00000027150	HTH_Tnp_Tc3_2 domain-containing protein.	Uncharacterized protein.	0.400
ENSPREP00000027813	ENSPREP00000029144	ENSPREP00000027813	ENSPREP00000029144	HTH_Tnp_Tc3_2 domain-containing protein.	DDE_3 domain-containing protein.	0.529
ENSPREP00000027813	gak	ENSPREP00000027813	ENSPREP00000012671	HTH_Tnp_Tc3_2 domain-containing protein.	Cyclin G associated kinase.	0.445
ENSPREP00000027813	grap2	ENSPREP00000027813	ENSPREP00000018946	HTH_Tnp_Tc3_2 domain-containing protein.	GRB2 related adaptor protein 2a.	0.618
ENSPREP00000027813	grb2	ENSPREP00000027813	ENSPREP00000022510	HTH_Tnp_Tc3_2 domain-containing protein.	Growth factor receptor-bound protein 2b.	0.523
ENSPREP00000027813	ift81	ENSPREP00000027813	ENSPREP00000024120	HTH_Tnp_Tc3_2 domain-containing protein.	Intraflagellar transport 81 homolog.	0.400
ENSPREP00000027813	nck1	ENSPREP00000027813	ENSPREP00000031849	HTH_Tnp_Tc3_2 domain-containing protein.	Cytoplasmic protein.	0.425
ENSPREP00000027813	nck2	ENSPREP00000027813	ENSPREP00000013658	HTH_Tnp_Tc3_2 domain-containing protein.	Cytoplasmic protein.	0.425
ENSPREP00000027813	ubxn7	ENSPREP00000027813	ENSPREP00000004268	HTH_Tnp_Tc3_2 domain-containing protein.	UBX domain protein 7.	0.415
ENSPREP00000029144	ENSPREP00000027813	ENSPREP00000029144	ENSPREP00000027813	DDE_3 domain-containing protein.	HTH_Tnp_Tc3_2 domain-containing protein.	0.529
gak	ENSPREP00000027813	ENSPREP00000012671	ENSPREP00000027813	Cyclin G associated kinase.	HTH_Tnp_Tc3_2 domain-containing protein.	0.445
grap2	ENSPREP00000027813	ENSPREP00000018946	ENSPREP00000027813	GRB2 related adaptor protein 2a.	HTH_Tnp_Tc3_2 domain-containing protein.	0.618
grap2	grb2	ENSPREP00000018946	ENSPREP00000022510	GRB2 related adaptor protein 2a.	Growth factor receptor-bound protein 2b.	0.870
grap2	nck1	ENSPREP00000018946	ENSPREP00000031849	GRB2 related adaptor protein 2a.	Cytoplasmic protein.	0.601
grap2	nck2	ENSPREP00000018946	ENSPREP00000013658	GRB2 related adaptor protein 2a.	Cytoplasmic protein.	0.601
grb2	ENSPREP00000027813	ENSPREP00000022510	ENSPREP00000027813	Growth factor receptor-bound protein 2b.	HTH_Tnp_Tc3_2 domain-containing protein.	0.523
grb2	grap2	ENSPREP00000022510	ENSPREP00000018946	Growth factor receptor-bound protein 2b.	GRB2 related adaptor protein 2a.	0.870

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About