ENSPREP00000027875 protein (Poecilia reticulata)

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSPREP00000027875

Histone H3; Belongs to the histone H3 family. (96 aa)

Predicted Functional Partners:

LOC103475867

0.898

LOC103475798

0.898

kdm6b

0.898

kdm6a

0.898

leo1

0.849

rbbp4

0.816

Arid4a

0.813

arid4b

0.813

suv39h1

0.809

eed

0.808

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arid4a	ENSPREP00000027875	ENSPREP00000005605	ENSPREP00000027875	Tudor domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.813
Arid4a	LOC103475798	ENSPREP00000005605	ENSPREP00000014271	Tudor domain-containing protein.	Lysine (K)-specific demethylase 6A, like.	0.478
Arid4a	LOC103475867	ENSPREP00000005605	ENSPREP00000002425	Tudor domain-containing protein.	Lysine (K)-specific demethylase 6B, b.	0.478
Arid4a	arid4b	ENSPREP00000005605	ENSPREP00000011747	Tudor domain-containing protein.	Translocase of outer mitochondrial membrane 20.	0.612
Arid4a	kdm6a	ENSPREP00000005605	ENSPREP00000030520	Tudor domain-containing protein.	Lysine (K)-specific demethylase 6A.	0.478
Arid4a	kdm6b	ENSPREP00000005605	ENSPREP00000021959	Tudor domain-containing protein.	Lysine (K)-specific demethylase 6B, a.	0.478
Arid4a	rbbp4	ENSPREP00000005605	ENSPREP00000032501	Tudor domain-containing protein.	Retinoblastoma binding protein 4.	0.991
ENSPREP00000027875	Arid4a	ENSPREP00000027875	ENSPREP00000005605	Histone H3; Belongs to the histone H3 family.	Tudor domain-containing protein.	0.813
ENSPREP00000027875	LOC103475798	ENSPREP00000027875	ENSPREP00000014271	Histone H3; Belongs to the histone H3 family.	Lysine (K)-specific demethylase 6A, like.	0.898
ENSPREP00000027875	LOC103475867	ENSPREP00000027875	ENSPREP00000002425	Histone H3; Belongs to the histone H3 family.	Lysine (K)-specific demethylase 6B, b.	0.898
ENSPREP00000027875	arid4b	ENSPREP00000027875	ENSPREP00000011747	Histone H3; Belongs to the histone H3 family.	Translocase of outer mitochondrial membrane 20.	0.813
ENSPREP00000027875	eed	ENSPREP00000027875	ENSPREP00000023484	Histone H3; Belongs to the histone H3 family.	Embryonic ectoderm development.	0.808
ENSPREP00000027875	kdm6a	ENSPREP00000027875	ENSPREP00000030520	Histone H3; Belongs to the histone H3 family.	Lysine (K)-specific demethylase 6A.	0.898
ENSPREP00000027875	kdm6b	ENSPREP00000027875	ENSPREP00000021959	Histone H3; Belongs to the histone H3 family.	Lysine (K)-specific demethylase 6B, a.	0.898
ENSPREP00000027875	leo1	ENSPREP00000027875	ENSPREP00000027692	Histone H3; Belongs to the histone H3 family.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.849
ENSPREP00000027875	rbbp4	ENSPREP00000027875	ENSPREP00000032501	Histone H3; Belongs to the histone H3 family.	Retinoblastoma binding protein 4.	0.816
ENSPREP00000027875	suv39h1	ENSPREP00000027875	ENSPREP00000012183	Histone H3; Belongs to the histone H3 family.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.809
LOC103475798	Arid4a	ENSPREP00000014271	ENSPREP00000005605	Lysine (K)-specific demethylase 6A, like.	Tudor domain-containing protein.	0.478
LOC103475798	ENSPREP00000027875	ENSPREP00000014271	ENSPREP00000027875	Lysine (K)-specific demethylase 6A, like.	Histone H3; Belongs to the histone H3 family.	0.898
LOC103475798	arid4b	ENSPREP00000014271	ENSPREP00000011747	Lysine (K)-specific demethylase 6A, like.	Translocase of outer mitochondrial membrane 20.	0.528

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.589

expected number of edges:

10

PPI enrichment p-value:

7.05e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

4 of 8

3.02

3.79

1.16e-07

GO:0098974

Postsynaptic actin cytoskeleton organization

4 of 15

2.74

3.41

4.54e-07

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

4 of 15

2.74

3.41

4.54e-07

GO:1901385

Regulation of voltage-gated calcium channel activity

4 of 39

2.33

2.78

4.11e-06

GO:0002027

Regulation of heart rate

4 of 40

2.32

2.77

4.11e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

4 of 8

3.02

4.04

3.84e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

4 of 14

2.77

3.74

1.11e-07

GO:0002102

Podosome

4 of 18

2.66

3.66

1.33e-07

GO:0033017

Sarcoplasmic reticulum membrane

4 of 31

2.43

3.28

4.74e-07

GO:0030175

Filopodium

4 of 72

2.06

2.57

5.11e-06

GO:0030018

Z disc

4 of 102

1.91

2.24

1.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36908

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF hand

7 of 31

2.67

6.88

3.20e-14

CL:36910

EF hand, and Syntrophin

4 of 12

2.84

3.88

6.57e-08

CL:36947

Mixed, incl. Torsin 1/2, and Torsin-1A-interacting protein 1/2

3 of 10

2.79

2.56

1.97e-05

CL:36950

Nitric-oxide synthase binding, and Torsin 1/2

2 of 5

2.92

1.39

0.0031

CL:36912

Mixed, incl. EF hand, and Syntrophin, split Pleckstrin homology (PH) domain

2 of 7

2.77

1.28

0.0047

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 407

1.31

1.26

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016010

Dystrophin-associated glycoprotein complex

5 of 24

2.64

4.6

1.60e-09

GOCC:0045202

Synapse

4 of 531

1.19

0.68

0.0232

GOCC:0016020

Membrane

9 of 5135

0.56

0.38

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015482

Syntrophin

4 of 4

3.32

4.32

1.44e-08

IPR041428

Syntrophin, split Pleckstrin homology (PH) domain

3 of 3

3.32

2.98

4.04e-06

IPR011993

PH-like domain superfamily

7 of 529

1.44

1.83

4.04e-06

IPR006020

PTB/PI domain

3 of 57

2.04

1.28

0.0035

IPR001478

PDZ domain

4 of 201

1.62

1.15

0.0035

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 39

2.2

1.64

0.00073

SM00233

Pleckstrin homology domain.

4 of 325

1.41

0.99

0.0050

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