zar1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

zar1

Zygote arrest 1. (330 aa)

Predicted Functional Partners:

LOC103462945

0.591

gdf9

0.544

sox17

0.529

wee2

0.510

LOC103478590

0.505

spata7

0.473

spag6

0.413

LOC103467207

0.406

LOC103474903

0.405

dmrt2

0.405

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103462945	LOC103474903	ENSPREP00000027203	ENSPREP00000014380	Forkhead box R1.	Tektin 1.	0.405
LOC103462945	LOC103478590	ENSPREP00000027203	ENSPREP00000001066	Forkhead box R1.	Speriolin_C domain-containing protein.	0.505
LOC103462945	dmrt2	ENSPREP00000027203	ENSPREP00000020688	Forkhead box R1.	Doublesex and mab-3 related transcription factor 2a.	0.414
LOC103462945	spag6	ENSPREP00000027203	ENSPREP00000022358	Forkhead box R1.	Sperm associated antigen 6.	0.413
LOC103462945	zar1	ENSPREP00000027203	ENSPREP00000027919	Forkhead box R1.	Zygote arrest 1.	0.591
LOC103467207	gdf9	ENSPREP00000022851	ENSPREP00000007532	Zgc:194189.	Growth differentiation factor 9.	0.431
LOC103467207	wee2	ENSPREP00000022851	ENSPREP00000030609	Zgc:194189.	Wee1-like protein kinase.	0.507
LOC103467207	zar1	ENSPREP00000022851	ENSPREP00000027919	Zgc:194189.	Zygote arrest 1.	0.406
LOC103474903	LOC103462945	ENSPREP00000014380	ENSPREP00000027203	Tektin 1.	Forkhead box R1.	0.405
LOC103474903	LOC103478590	ENSPREP00000014380	ENSPREP00000001066	Tektin 1.	Speriolin_C domain-containing protein.	0.419
LOC103474903	zar1	ENSPREP00000014380	ENSPREP00000027919	Tektin 1.	Zygote arrest 1.	0.405
LOC103478590	LOC103462945	ENSPREP00000001066	ENSPREP00000027203	Speriolin_C domain-containing protein.	Forkhead box R1.	0.505
LOC103478590	LOC103474903	ENSPREP00000001066	ENSPREP00000014380	Speriolin_C domain-containing protein.	Tektin 1.	0.419
LOC103478590	dmrt2	ENSPREP00000001066	ENSPREP00000020688	Speriolin_C domain-containing protein.	Doublesex and mab-3 related transcription factor 2a.	0.407
LOC103478590	spag6	ENSPREP00000001066	ENSPREP00000022358	Speriolin_C domain-containing protein.	Sperm associated antigen 6.	0.473
LOC103478590	zar1	ENSPREP00000001066	ENSPREP00000027919	Speriolin_C domain-containing protein.	Zygote arrest 1.	0.505
dmrt2	LOC103462945	ENSPREP00000020688	ENSPREP00000027203	Doublesex and mab-3 related transcription factor 2a.	Forkhead box R1.	0.414
dmrt2	LOC103478590	ENSPREP00000020688	ENSPREP00000001066	Doublesex and mab-3 related transcription factor 2a.	Speriolin_C domain-containing protein.	0.407
dmrt2	zar1	ENSPREP00000020688	ENSPREP00000027919	Doublesex and mab-3 related transcription factor 2a.	Zygote arrest 1.	0.405
gdf9	LOC103467207	ENSPREP00000007532	ENSPREP00000022851	Growth differentiation factor 9.	Zgc:194189.	0.431

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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