ing3 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ing3

Inhibitor of growth protein. (418 aa)

Predicted Functional Partners:

meaf6

0.949

dmap1

0.948

ruvbl1

0.941

ENSPREP00000007462

0.937

rsph3

0.937

yeats4

0.936

actl6a

0.926

ruvbl2

0.912

ENSPREP00000022903

0.884

Trrap

0.884

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000007462	ENSPREP00000022903	ENSPREP00000007462	ENSPREP00000022903	Uncharacterized protein.	Uncharacterized protein.	0.908
ENSPREP00000007462	Trrap	ENSPREP00000007462	ENSPREP00000022921	Uncharacterized protein.	FATC domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.908
ENSPREP00000007462	actl6a	ENSPREP00000007462	ENSPREP00000022295	Uncharacterized protein.	Actin-like 6A; Belongs to the actin family.	0.902
ENSPREP00000007462	dmap1	ENSPREP00000007462	ENSPREP00000023811	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.971
ENSPREP00000007462	ing3	ENSPREP00000007462	ENSPREP00000028076	Uncharacterized protein.	Inhibitor of growth protein.	0.937
ENSPREP00000007462	meaf6	ENSPREP00000007462	ENSPREP00000014770	Uncharacterized protein.	MYST/Esa1-associated factor 6.	0.954
ENSPREP00000007462	ruvbl1	ENSPREP00000007462	ENSPREP00000018143	Uncharacterized protein.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.931
ENSPREP00000007462	ruvbl2	ENSPREP00000007462	ENSPREP00000012900	Uncharacterized protein.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.892
ENSPREP00000007462	yeats4	ENSPREP00000007462	ENSPREP00000006340	Uncharacterized protein.	YEATS domain containing 4.	0.932
ENSPREP00000022903	ENSPREP00000007462	ENSPREP00000022903	ENSPREP00000007462	Uncharacterized protein.	Uncharacterized protein.	0.908
ENSPREP00000022903	Trrap	ENSPREP00000022903	ENSPREP00000022921	Uncharacterized protein.	FATC domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.925
ENSPREP00000022903	actl6a	ENSPREP00000022903	ENSPREP00000022295	Uncharacterized protein.	Actin-like 6A; Belongs to the actin family.	0.955
ENSPREP00000022903	dmap1	ENSPREP00000022903	ENSPREP00000023811	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.960
ENSPREP00000022903	ing3	ENSPREP00000022903	ENSPREP00000028076	Uncharacterized protein.	Inhibitor of growth protein.	0.884
ENSPREP00000022903	meaf6	ENSPREP00000022903	ENSPREP00000014770	Uncharacterized protein.	MYST/Esa1-associated factor 6.	0.960
ENSPREP00000022903	ruvbl1	ENSPREP00000022903	ENSPREP00000018143	Uncharacterized protein.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.965
ENSPREP00000022903	ruvbl2	ENSPREP00000022903	ENSPREP00000012900	Uncharacterized protein.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.915
ENSPREP00000022903	yeats4	ENSPREP00000022903	ENSPREP00000006340	Uncharacterized protein.	YEATS domain containing 4.	0.948
Trrap	ENSPREP00000007462	ENSPREP00000022921	ENSPREP00000007462	FATC domain-containing protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.908
Trrap	ENSPREP00000022903	ENSPREP00000022921	ENSPREP00000022903	FATC domain-containing protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.925

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.756

expected number of edges:

22

PPI enrichment p-value:

0.497

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004692

cGMP-dependent protein kinase activity

3 of 3

3.08

2.57

2.17e-05

GO:0030553

cGMP binding

3 of 10

2.55

2.15

0.00010

GO:0004017

Adenylate kinase activity

2 of 12

2.3

0.84

0.0286

GO:0004550

Nucleoside diphosphate kinase activity

2 of 17

2.15

0.79

0.0343

GO:0016301

Kinase activity

5 of 573

1.02

0.58

0.0286

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2644

Mixed, incl. cGMP effects, and PTW/PP1 phosphatase complex

5 of 15

2.6

4.3

6.04e-09

CL:2662

Na+/H+ exchanger, and MRVI1 protein

2 of 6

2.6

1.05

0.0122

CL:2647

PTW/PP1 phosphatase complex, and cGMP-dependent protein kinase activity

2 of 5

2.68

1.05

0.0122

CL:16049

AAA domain, and GDP metabolic process

2 of 5

2.68

1.05

0.0122

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04540

Gap junction

4 of 72

1.82

1.94

6.48e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418457

cGMP effects

3 of 9

2.6

2.22

7.81e-05

MAP-392154

Nitric oxide stimulates guanylate cyclase

3 of 12

2.47

2.12

0.00011

MAP-418346

Platelet homeostasis

4 of 43

2.04

2.05

7.62e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 562

1.03

0.64

0.0162

KW-0808

Transferase

6 of 1172

0.79

0.48

0.0236

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