node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCM7 | Mcm5 | ENSPREP00000020776 | ENSPREP00000022230 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Uncharacterized protein. | 0.996 |
MCM7 | cdc45 | ENSPREP00000020776 | ENSPREP00000017327 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.987 |
MCM7 | cdc6 | ENSPREP00000020776 | ENSPREP00000032222 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.990 |
MCM7 | cdc7 | ENSPREP00000020776 | ENSPREP00000011666 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Cell division cycle 7 homolog (S. cerevisiae). | 0.970 |
MCM7 | cdt1 | ENSPREP00000020776 | ENSPREP00000011428 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Chromatin licensing and DNA replication factor 1. | 0.994 |
MCM7 | mcm2 | ENSPREP00000020776 | ENSPREP00000033565 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.997 |
MCM7 | mcm3 | ENSPREP00000020776 | ENSPREP00000028616 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.998 |
MCM7 | mcm4 | ENSPREP00000020776 | ENSPREP00000012626 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.997 |
MCM7 | mcm6 | ENSPREP00000020776 | ENSPREP00000031351 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.998 |
MCM7 | orc2 | ENSPREP00000020776 | ENSPREP00000031604 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Origin recognition complex, subunit 2. | 0.969 |
Mcm5 | MCM7 | ENSPREP00000022230 | ENSPREP00000020776 | Uncharacterized protein. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.996 |
Mcm5 | cdc45 | ENSPREP00000022230 | ENSPREP00000017327 | Uncharacterized protein. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.999 |
Mcm5 | cdc6 | ENSPREP00000022230 | ENSPREP00000032222 | Uncharacterized protein. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
Mcm5 | cdc7 | ENSPREP00000022230 | ENSPREP00000011666 | Uncharacterized protein. | Cell division cycle 7 homolog (S. cerevisiae). | 0.998 |
Mcm5 | cdt1 | ENSPREP00000022230 | ENSPREP00000011428 | Uncharacterized protein. | Chromatin licensing and DNA replication factor 1. | 0.999 |
Mcm5 | mcm2 | ENSPREP00000022230 | ENSPREP00000033565 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
Mcm5 | mcm3 | ENSPREP00000022230 | ENSPREP00000028616 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
Mcm5 | mcm4 | ENSPREP00000022230 | ENSPREP00000012626 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
Mcm5 | mcm6 | ENSPREP00000022230 | ENSPREP00000031351 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
Mcm5 | orc2 | ENSPREP00000022230 | ENSPREP00000031604 | Uncharacterized protein. | Origin recognition complex, subunit 2. | 0.999 |