STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prdm1PR domain containing 1a, with ZNF domain. (876 aa)    
Predicted Functional Partners:
mef2c
Myocyte enhancer factor 2cb.
      
 0.597
LOC103467753
CCAAT enhancer binding protein beta.
      
 0.593
satb2
SATB homeobox 2.
      
 0.536
irf8
Interferon regulatory factor 8.
   
 
 0.486
LOC103473086
Exostoses (multiple) 1c; Belongs to the glycosyltransferase 47 family.
      
 0.471
pkdcc
Protein kinase domain containing, cytoplasmic b.
    
 0.418
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.407
myoc
Myocilin.
      
 0.404
sh3rf3
SH3 domain containing ring finger 3.
    
 0.404
aicda
Activation-induced cytidine deaminase.
      
 0.400
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.