LOC103465029 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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protein homology

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Score

LOC103465029

Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (618 aa)

Predicted Functional Partners:

gak

0.979

pex26

0.772

rsad2

0.735

DNM3

0.696

dnajc6

0.693

ENSPREP00000015831

0.674

ENSPREP00000015870

0.674

ENSPREP00000015917

0.674

itsn2

0.674

ENSPREP00000020277

0.664

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNM3	ENSPREP00000015831	ENSPREP00000000994	ENSPREP00000015831	Dynamin 3.	Uncharacterized protein.	0.674
DNM3	ENSPREP00000015870	ENSPREP00000000994	ENSPREP00000015870	Dynamin 3.	Uncharacterized protein.	0.674
DNM3	ENSPREP00000015917	ENSPREP00000000994	ENSPREP00000015917	Dynamin 3.	EH domain-containing protein.	0.674
DNM3	ENSPREP00000020277	ENSPREP00000000994	ENSPREP00000020277	Dynamin 3.	RBR-type E3 ubiquitin transferase.	0.675
DNM3	LOC103465029	ENSPREP00000000994	ENSPREP00000028914	Dynamin 3.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.696
DNM3	dnajc6	ENSPREP00000000994	ENSPREP00000016154	Dynamin 3.	DnaJ (Hsp40) homolog, subfamily C, member 6.	0.693
DNM3	gak	ENSPREP00000000994	ENSPREP00000012671	Dynamin 3.	Cyclin G associated kinase.	0.979
DNM3	itsn2	ENSPREP00000000994	ENSPREP00000017512	Dynamin 3.	Intersectin 2a.	0.674
DNM3	rsad2	ENSPREP00000000994	ENSPREP00000031618	Dynamin 3.	Radical S-adenosyl methionine domain containing 2.	0.490
ENSPREP00000015831	DNM3	ENSPREP00000015831	ENSPREP00000000994	Uncharacterized protein.	Dynamin 3.	0.674
ENSPREP00000015831	ENSPREP00000015870	ENSPREP00000015831	ENSPREP00000015870	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSPREP00000015831	ENSPREP00000015917	ENSPREP00000015831	ENSPREP00000015917	Uncharacterized protein.	EH domain-containing protein.	0.952
ENSPREP00000015831	LOC103465029	ENSPREP00000015831	ENSPREP00000028914	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.674
ENSPREP00000015831	gak	ENSPREP00000015831	ENSPREP00000012671	Uncharacterized protein.	Cyclin G associated kinase.	0.756
ENSPREP00000015831	itsn2	ENSPREP00000015831	ENSPREP00000017512	Uncharacterized protein.	Intersectin 2a.	0.953
ENSPREP00000015870	DNM3	ENSPREP00000015870	ENSPREP00000000994	Uncharacterized protein.	Dynamin 3.	0.674
ENSPREP00000015870	ENSPREP00000015831	ENSPREP00000015870	ENSPREP00000015831	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSPREP00000015870	ENSPREP00000015917	ENSPREP00000015870	ENSPREP00000015917	Uncharacterized protein.	EH domain-containing protein.	0.952
ENSPREP00000015870	LOC103465029	ENSPREP00000015870	ENSPREP00000028914	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.674
ENSPREP00000015870	gak	ENSPREP00000015870	ENSPREP00000012671	Uncharacterized protein.	Cyclin G associated kinase.	0.756

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

0.232

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

9 of 175

2.03

5.27

5.11e-14

GO:0046486

Glycerolipid metabolic process

10 of 342

1.78

4.32

5.11e-14

GO:0006629

Lipid metabolic process

11 of 1175

1.29

2.15

1.13e-11

GO:0045017

Glycerolipid biosynthetic process

5 of 205

1.7

2.0

2.23e-05

GO:0043647

Inositol phosphate metabolic process

3 of 34

2.26

1.8

0.00037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004435

Phosphatidylinositol phospholipase C activity

4 of 24

2.54

3.22

7.90e-07

GO:0042578

Phosphoric ester hydrolase activity

8 of 473

1.55

2.52

1.51e-08

GO:0046030

Inositol trisphosphate phosphatase activity

2 of 17

2.39

1.12

0.0087

GO:0016791

Phosphatase activity

4 of 351

1.37

0.99

0.0046

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 45

1.97

0.71

0.0463

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27029

Inositol phosphate metabolism, and Inositol hexakisphosphate 5-kinase activity

9 of 84

2.35

7.32

5.58e-17

CL:27030

Inositol phosphate metabolism

8 of 67

2.39

6.88

1.86e-15

CL:27032

Inositol phosphate metabolism

7 of 45

2.51

6.48

6.76e-14

CL:27033

Inositol phosphate metabolism

6 of 39

2.5

5.46

1.34e-11

CL:27060

Mixed, incl. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain, and 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain

4 of 10

2.92

4.19

1.81e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret00562

Inositol phosphate metabolism

11 of 82

2.45

10.56

4.53e-25

pret04070

Phosphatidylinositol signaling system

11 of 88

2.41

10.39

4.68e-25

pret01100

Metabolic pathways

11 of 1488

1.19

1.85

5.14e-12

pret04020

Calcium signaling pathway

4 of 250

1.52

0.00019

pret04370

VEGF signaling pathway

2 of 64

1.81

0.94

0.0147

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

8 of 73

2.36

6.63

4.73e-15

MAP-1855204

Synthesis of IP3 and IP4 in the cytosol

5 of 45

2.36

3.92

1.55e-08

MAP-1660517

Synthesis of PIPs at the late endosome membrane

2 of 7

2.77

1.38

0.0031

MAP-202403

TCR signaling

3 of 80

1.89

1.27

0.0031

MAP-1660516

Synthesis of PIPs at the early endosome membrane

2 of 15

2.44

1.18

0.0068

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

5 of 102

2.01

3.0

3.08e-07

KW-0442

Lipid degradation

3 of 45

2.14

1.86

0.00024

KW-0378

Hydrolase

5 of 768

1.13

0.92

0.0019

KW-0807

Transducer

4 of 562

1.17

0.79

0.0089

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001711

Phospholipase C, phosphatidylinositol-specific, Y domain

4 of 23

2.56

2.9

3.59e-06

IPR001192

Phosphoinositide phospholipase C family

4 of 23

2.56

2.9

3.59e-06

IPR000909

Phosphatidylinositol-specific phospholipase C, X domain

4 of 29

2.46

2.86

3.59e-06

IPR017946

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

4 of 40

2.32

2.66

6.91e-06

IPR035892

C2 domain superfamily

5 of 228

1.66

1.79

6.56e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00149

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00148

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 185

1.65

1.53

0.00037

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