clg6h11orf49 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

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Experiments

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[Homology]

Score

clg6h11orf49

Zgc:92873. (321 aa)

Predicted Functional Partners:

LRRC49

0.730

tpgs2

0.724

ttll1

0.671

nicn1

0.615

clg5h12orf10

0.551

mfsd5

0.497

pfdn5

0.477

LOC103470667

0.472

ttl

0.448

eif3f

0.439

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103470667	clg6h11orf49	ENSPREP00000017637	ENSPREP00000029385	Uncharacterized protein.	Zgc:92873.	0.472
LRRC49	clg6h11orf49	ENSPREP00000011833	ENSPREP00000029385	Leucine rich repeat containing 49.	Zgc:92873.	0.730
LRRC49	eif3f	ENSPREP00000011833	ENSPREP00000029536	Leucine rich repeat containing 49.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.516
LRRC49	nicn1	ENSPREP00000011833	ENSPREP00000031670	Leucine rich repeat containing 49.	Nicolin 1.	0.822
LRRC49	tpgs2	ENSPREP00000011833	ENSPREP00000031247	Leucine rich repeat containing 49.	Tubulin polyglutamylase complex subunit 2.	0.822
LRRC49	ttl	ENSPREP00000011833	ENSPREP00000002309	Leucine rich repeat containing 49.	Tubulin tyrosine ligase.	0.700
LRRC49	ttll1	ENSPREP00000011833	ENSPREP00000033940	Leucine rich repeat containing 49.	Tubulin tyrosine ligase-like family, member 1.	0.861
clg5h12orf10	clg6h11orf49	ENSPREP00000011221	ENSPREP00000029385	Melanocyte proliferating gene 1.	Zgc:92873.	0.551
clg5h12orf10	mfsd5	ENSPREP00000011221	ENSPREP00000030189	Melanocyte proliferating gene 1.	Major facilitator superfamily domain containing 5.	0.560
clg5h12orf10	pfdn5	ENSPREP00000011221	ENSPREP00000024157	Melanocyte proliferating gene 1.	Prefoldin 5.	0.549
clg6h11orf49	LOC103470667	ENSPREP00000029385	ENSPREP00000017637	Zgc:92873.	Uncharacterized protein.	0.472
clg6h11orf49	LRRC49	ENSPREP00000029385	ENSPREP00000011833	Zgc:92873.	Leucine rich repeat containing 49.	0.730
clg6h11orf49	clg5h12orf10	ENSPREP00000029385	ENSPREP00000011221	Zgc:92873.	Melanocyte proliferating gene 1.	0.551
clg6h11orf49	eif3f	ENSPREP00000029385	ENSPREP00000029536	Zgc:92873.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.439
clg6h11orf49	mfsd5	ENSPREP00000029385	ENSPREP00000030189	Zgc:92873.	Major facilitator superfamily domain containing 5.	0.497
clg6h11orf49	nicn1	ENSPREP00000029385	ENSPREP00000031670	Zgc:92873.	Nicolin 1.	0.615
clg6h11orf49	pfdn5	ENSPREP00000029385	ENSPREP00000024157	Zgc:92873.	Prefoldin 5.	0.477
clg6h11orf49	tpgs2	ENSPREP00000029385	ENSPREP00000031247	Zgc:92873.	Tubulin polyglutamylase complex subunit 2.	0.724
clg6h11orf49	ttl	ENSPREP00000029385	ENSPREP00000002309	Zgc:92873.	Tubulin tyrosine ligase.	0.448
clg6h11orf49	ttll1	ENSPREP00000029385	ENSPREP00000033940	Zgc:92873.	Tubulin tyrosine ligase-like family, member 1.	0.671

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

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