ENSPREP00000029577 protein (Poecilia reticulata)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSPREP00000029577

Erythrocyte membrane protein band 4.1a. (554 aa)

Predicted Functional Partners:

ENSPREP00000029505

0.907

ENSPREP00000031260

0.770

LOC103475843

0.694

cask

0.694

ENSPREP00000032303

0.691

ptpn2

0.613

LOC103472442

0.602

mpp1

0.485

epb41l5

0.415

LOC103474260

0.410

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000029505	ENSPREP00000029577	ENSPREP00000029505	ENSPREP00000029577	4_1_CTD domain-containing protein.	Erythrocyte membrane protein band 4.1a.	0.907
ENSPREP00000029505	LOC103474260	ENSPREP00000029505	ENSPREP00000016399	4_1_CTD domain-containing protein.	Cell adhesion molecule 1b.	0.410
ENSPREP00000029505	LOC103475843	ENSPREP00000029505	ENSPREP00000013706	4_1_CTD domain-containing protein.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.694
ENSPREP00000029505	cask	ENSPREP00000029505	ENSPREP00000030734	4_1_CTD domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.694
ENSPREP00000029505	epb41l5	ENSPREP00000029505	ENSPREP00000023604	4_1_CTD domain-containing protein.	Erythrocyte membrane protein band 4.1 like 5.	0.787
ENSPREP00000029505	mpp1	ENSPREP00000029505	ENSPREP00000002565	4_1_CTD domain-containing protein.	Membrane protein, palmitoylated 1; Belongs to the MAGUK family.	0.485
ENSPREP00000029577	ENSPREP00000029505	ENSPREP00000029577	ENSPREP00000029505	Erythrocyte membrane protein band 4.1a.	4_1_CTD domain-containing protein.	0.907
ENSPREP00000029577	ENSPREP00000031260	ENSPREP00000029577	ENSPREP00000031260	Erythrocyte membrane protein band 4.1a.	Uncharacterized protein.	0.770
ENSPREP00000029577	ENSPREP00000032303	ENSPREP00000029577	ENSPREP00000032303	Erythrocyte membrane protein band 4.1a.	Uncharacterized protein.	0.691
ENSPREP00000029577	LOC103472442	ENSPREP00000029577	ENSPREP00000012910	Erythrocyte membrane protein band 4.1a.	Tyrosine-protein phosphatase non-receptor type.	0.602
ENSPREP00000029577	LOC103474260	ENSPREP00000029577	ENSPREP00000016399	Erythrocyte membrane protein band 4.1a.	Cell adhesion molecule 1b.	0.410
ENSPREP00000029577	LOC103475843	ENSPREP00000029577	ENSPREP00000013706	Erythrocyte membrane protein band 4.1a.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.694
ENSPREP00000029577	cask	ENSPREP00000029577	ENSPREP00000030734	Erythrocyte membrane protein band 4.1a.	Uncharacterized protein; Belongs to the MAGUK family.	0.694
ENSPREP00000029577	epb41l5	ENSPREP00000029577	ENSPREP00000023604	Erythrocyte membrane protein band 4.1a.	Erythrocyte membrane protein band 4.1 like 5.	0.415
ENSPREP00000029577	mpp1	ENSPREP00000029577	ENSPREP00000002565	Erythrocyte membrane protein band 4.1a.	Membrane protein, palmitoylated 1; Belongs to the MAGUK family.	0.485
ENSPREP00000029577	ptpn2	ENSPREP00000029577	ENSPREP00000016958	Erythrocyte membrane protein band 4.1a.	Tyrosine-protein phosphatase non-receptor type.	0.613
ENSPREP00000031260	ENSPREP00000029577	ENSPREP00000031260	ENSPREP00000029577	Uncharacterized protein.	Erythrocyte membrane protein band 4.1a.	0.770
ENSPREP00000031260	epb41l5	ENSPREP00000031260	ENSPREP00000023604	Uncharacterized protein.	Erythrocyte membrane protein band 4.1 like 5.	0.462
ENSPREP00000032303	ENSPREP00000029577	ENSPREP00000032303	ENSPREP00000029577	Uncharacterized protein.	Erythrocyte membrane protein band 4.1a.	0.691
LOC103472442	ENSPREP00000029577	ENSPREP00000012910	ENSPREP00000029577	Tyrosine-protein phosphatase non-receptor type.	Erythrocyte membrane protein band 4.1a.	0.602

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

8 of 941

1.07

1.08

7.32e-05

GO:0006470

Protein dephosphorylation

3 of 67

1.8

1.07

0.0074

GO:0036211

Protein modification process

7 of 1176

0.92

0.7

0.0034

GO:0006468

Protein phosphorylation

4 of 415

1.13

0.57

0.0437

GO:1901564

Organonitrogen compound metabolic process

8 of 2532

0.64

0.41

0.0241

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017018

Myosin phosphatase activity

3 of 45

1.97

1.16

0.0058

GO:0140096

Catalytic activity, acting on a protein

7 of 1272

0.89

0.64

0.0058

GO:0004672

Protein kinase activity

4 of 415

1.13

0.59

0.0390

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. GDP metabolic process, and Signaling receptor complex adaptor activity

3 of 5

2.92

2.59

1.88e-05

CL:1988

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

4 of 32

2.24

2.42

1.88e-05

CL:1900

Mixed, incl. Serine/threonine-protein kinase, and MAPK cascade

5 of 137

1.71

2.01

2.10e-05

CL:1990

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

3 of 26

2.21

1.84

0.00029

CL:13390

Cyclic nucleotide-dependent protein kinase activity, and PPM-type phosphatase, divalent cation binding

2 of 6

2.67

1.43

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

8 of 394

1.45

2.15

1.07e-07

IPR011009

Protein kinase-like domain superfamily

8 of 431

1.41

2.07

1.08e-07

IPR036457

PPM-type phosphatase-like domain superfamily

3 of 30

2.14

1.45

0.0017

IPR001932

PPM-type phosphatase-like domain

3 of 30

2.14

1.45

0.0017

IPR000222

PPM-type phosphatase, divalent cation binding

2 of 12

2.37

0.84

0.0285

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00331

Sigma factor PP2C-like phosphatases

2 of 22

2.1

0.73

0.0449

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