LOC103466769 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103466769

Aminopeptidase. (948 aa)

Predicted Functional Partners:

gclc

0.923

lap3

0.916

gss

0.915

LOC103470058

0.915

LOC103466275

0.905

chac2

0.902

LOC103462740

0.902

anpep

0.902

LOC103472371

0.900

ENSPREP00000010743

0.900

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010743	LOC103462740	ENSPREP00000010743	ENSPREP00000013187	Si:ch211-195e19.1.	Aminopeptidase.	0.900
ENSPREP00000010743	LOC103466275	ENSPREP00000010743	ENSPREP00000003542	Si:ch211-195e19.1.	Aminopeptidase.	0.900
ENSPREP00000010743	LOC103466769	ENSPREP00000010743	ENSPREP00000029703	Si:ch211-195e19.1.	Aminopeptidase.	0.900
ENSPREP00000010743	LOC103470058	ENSPREP00000010743	ENSPREP00000018090	Si:ch211-195e19.1.	Zgc:152830.	0.900
ENSPREP00000010743	anpep	ENSPREP00000010743	ENSPREP00000029610	Si:ch211-195e19.1.	Aminopeptidase.	0.900
ENSPREP00000010743	lap3	ENSPREP00000010743	ENSPREP00000000113	Si:ch211-195e19.1.	Leucine aminopeptidase 3.	0.900
LOC103462740	ENSPREP00000010743	ENSPREP00000013187	ENSPREP00000010743	Aminopeptidase.	Si:ch211-195e19.1.	0.900
LOC103462740	LOC103466275	ENSPREP00000013187	ENSPREP00000003542	Aminopeptidase.	Aminopeptidase.	0.905
LOC103462740	LOC103466769	ENSPREP00000013187	ENSPREP00000029703	Aminopeptidase.	Aminopeptidase.	0.902
LOC103462740	LOC103470058	ENSPREP00000013187	ENSPREP00000018090	Aminopeptidase.	Zgc:152830.	0.915
LOC103462740	LOC103472371	ENSPREP00000013187	ENSPREP00000010378	Aminopeptidase.	Gamma-glutamylcyclotransferase a.	0.900
LOC103462740	anpep	ENSPREP00000013187	ENSPREP00000029610	Aminopeptidase.	Aminopeptidase.	0.902
LOC103462740	chac2	ENSPREP00000013187	ENSPREP00000008158	Aminopeptidase.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.902
LOC103462740	gclc	ENSPREP00000013187	ENSPREP00000032692	Aminopeptidase.	Glutamate-cysteine ligase, catalytic subunit.	0.923
LOC103462740	gss	ENSPREP00000013187	ENSPREP00000004996	Aminopeptidase.	Glutathione synthetase.	0.915
LOC103462740	lap3	ENSPREP00000013187	ENSPREP00000000113	Aminopeptidase.	Leucine aminopeptidase 3.	0.916
LOC103466275	ENSPREP00000010743	ENSPREP00000003542	ENSPREP00000010743	Aminopeptidase.	Si:ch211-195e19.1.	0.900
LOC103466275	LOC103462740	ENSPREP00000003542	ENSPREP00000013187	Aminopeptidase.	Aminopeptidase.	0.905
LOC103466275	LOC103466769	ENSPREP00000003542	ENSPREP00000029703	Aminopeptidase.	Aminopeptidase.	0.905
LOC103466275	LOC103470058	ENSPREP00000003542	ENSPREP00000018090	Aminopeptidase.	Zgc:152830.	0.915

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.925

expected number of edges:

11

PPI enrichment p-value:

1.31e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006312

Mitotic recombination

6 of 20

2.79

6.33

8.67e-13

GO:0006310

DNA recombination

10 of 176

2.07

6.2

8.80e-17

GO:0000724

Double-strand break repair via homologous recombination

8 of 89

2.27

6.08

3.45e-14

GO:0045003

Double-strand break repair via synthesis-dependent strand annealing

5 of 7

3.17

6.04

8.13e-12

GO:0006302

Double-strand break repair

9 of 173

2.03

5.38

2.31e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140664

ATP-dependent DNA damage sensor activity

5 of 18

2.76

4.83

7.97e-10

GO:0008094

ATP-dependent activity, acting on DNA

6 of 107

2.07

3.8

3.86e-09

GO:0003697

Single-stranded DNA binding

4 of 87

1.98

2.16

3.39e-05

GO:0000150

DNA strand exchange activity

2 of 2

3.32

1.9

0.00038

GO:0003677

DNA binding

8 of 2428

0.84

0.71

0.00054

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033061

DNA recombinase mediator complex

5 of 6

3.24

6.17

5.15e-12

GO:0000781

Chromosome, telomeric region

4 of 56

2.17

2.67

4.39e-06

GO:0000228

Nuclear chromosome

5 of 149

1.84

2.48

2.44e-06

GO:0033065

Rad51C-XRCC3 complex

2 of 2

3.32

1.94

0.00032

GO:0032798

Swi5-Sfr1 complex

2 of 2

3.32

1.94

0.00032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35713948

(2022) Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex.

3 of 30

2.32

1.82

0.00037

PMID:24742317

(2014) Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana.

2 of 10

2.62

1.23

0.0057

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

1.02

0.0132

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7057

Homologous DNA Pairing and Strand Exchange, and DNA replication factor A complex

6 of 22

2.75

5.95

4.36e-12

CL:7085

DNA recombination and repair protein Rad51-like, C-terminal

4 of 6

3.14

4.5

6.07e-09

CL:35651

Mixed, incl. Swi5-Sfr1 complex, and TRAM1-like protein

3 of 7

2.95

2.88

5.51e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03440

Homologous recombination

2 of 27

2.19

0.99

0.0141

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5693579

Homologous DNA Pairing and Strand Exchange

4 of 26

2.5

3.1

1.31e-06

MAP-5693568

Resolution of D-loop Structures through Holliday Junction Intermediates

4 of 30

2.44

3.07

1.31e-06

MAP-5693537

Resolution of D-Loop Structures

4 of 30

2.44

3.07

1.31e-06

MAP-5685942

HDR through Homologous Recombination (HRR)

4 of 64

2.11

2.59

5.52e-06

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

5 of 140

1.87

2.56

1.78e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033061

DNA recombinase mediator complex

6 of 7

3.25

7.73

6.11e-15

GOCC:0000228

Nuclear chromosome

5 of 207

1.7

1.99

2.21e-05

GOCC:0033065

Rad51C-XRCC3 complex

2 of 2

3.32

1.89

0.00039

GOCC:0032798

Swi5-Sfr1 complex

2 of 2

3.32

1.89

0.00039

GOCC:0033063

Rad51B-Rad51C-Rad51D-XRCC2 complex

2 of 3

3.14

1.86

0.00044

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020588

DNA recombination and repair protein RecA-like, ATP-binding domain

5 of 6

3.24

5.77

2.90e-11

IPR013632

DNA recombination and repair protein Rad51-like, C-terminal

5 of 6

3.24

5.77

2.90e-11

IPR016467

DNA recombination and repair protein, RecA-like

2 of 2

3.32

1.4

0.0030

IPR010995

DNA repair Rad51/transcription factor NusA, alpha-helical

2 of 2

3.32

1.4

0.0030

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 151

1.74

1.54

0.00050

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 7

2.77

1.4

0.0029

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