sypl2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

sypl2

Synaptophysin-like 2a. (234 aa)

Predicted Functional Partners:

LOC103472839

0.523

ENSPREP00000002501

0.523

ENSPREP00000016345

0.523

snap25

0.415

ENSPREP00000004746

0.407

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002501	ENSPREP00000004746	ENSPREP00000002501	ENSPREP00000004746	Vesicle-associated membrane protein 2.	V-SNARE coiled-coil homology domain-containing protein.	0.765
ENSPREP00000002501	snap25	ENSPREP00000002501	ENSPREP00000028419	Vesicle-associated membrane protein 2.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.951
ENSPREP00000002501	sypl2	ENSPREP00000002501	ENSPREP00000029757	Vesicle-associated membrane protein 2.	Synaptophysin-like 2a.	0.523
ENSPREP00000004746	ENSPREP00000002501	ENSPREP00000004746	ENSPREP00000002501	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 2.	0.765
ENSPREP00000004746	ENSPREP00000016345	ENSPREP00000004746	ENSPREP00000016345	V-SNARE coiled-coil homology domain-containing protein.	Zgc:92912.	0.765
ENSPREP00000004746	LOC103472839	ENSPREP00000004746	ENSPREP00000001577	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 1.	0.975
ENSPREP00000004746	snap25	ENSPREP00000004746	ENSPREP00000028419	V-SNARE coiled-coil homology domain-containing protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.989
ENSPREP00000004746	sypl2	ENSPREP00000004746	ENSPREP00000029757	V-SNARE coiled-coil homology domain-containing protein.	Synaptophysin-like 2a.	0.407
ENSPREP00000016345	ENSPREP00000004746	ENSPREP00000016345	ENSPREP00000004746	Zgc:92912.	V-SNARE coiled-coil homology domain-containing protein.	0.765
ENSPREP00000016345	snap25	ENSPREP00000016345	ENSPREP00000028419	Zgc:92912.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.951
ENSPREP00000016345	sypl2	ENSPREP00000016345	ENSPREP00000029757	Zgc:92912.	Synaptophysin-like 2a.	0.523
LOC103472839	ENSPREP00000004746	ENSPREP00000001577	ENSPREP00000004746	Vesicle-associated membrane protein 1.	V-SNARE coiled-coil homology domain-containing protein.	0.975
LOC103472839	snap25	ENSPREP00000001577	ENSPREP00000028419	Vesicle-associated membrane protein 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.951
LOC103472839	sypl2	ENSPREP00000001577	ENSPREP00000029757	Vesicle-associated membrane protein 1.	Synaptophysin-like 2a.	0.523
snap25	ENSPREP00000002501	ENSPREP00000028419	ENSPREP00000002501	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 2.	0.951
snap25	ENSPREP00000004746	ENSPREP00000028419	ENSPREP00000004746	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	V-SNARE coiled-coil homology domain-containing protein.	0.989
snap25	ENSPREP00000016345	ENSPREP00000028419	ENSPREP00000016345	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Zgc:92912.	0.951
snap25	LOC103472839	ENSPREP00000028419	ENSPREP00000001577	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 1.	0.951
snap25	sypl2	ENSPREP00000028419	ENSPREP00000029757	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Synaptophysin-like 2a.	0.415
sypl2	ENSPREP00000002501	ENSPREP00000029757	ENSPREP00000002501	Synaptophysin-like 2a.	Vesicle-associated membrane protein 2.	0.523

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

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