usp48 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

usp48

Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1043 aa)

Predicted Functional Partners:

trip12

0.814

rps27a

0.797

uba52

0.794

ubl7

0.699

LOC103470505

0.672

LOC103469572

0.659

LOC103473816

0.659

LOC103473320

0.659

usp5

0.646

usp13

0.646

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103469572	LOC103470505	ENSPREP00000021110	ENSPREP00000009694	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin like 4A.	0.468
LOC103469572	LOC103473816	ENSPREP00000021110	ENSPREP00000022240	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.902
LOC103469572	rps27a	ENSPREP00000021110	ENSPREP00000018427	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ribosomal protein S27a.	0.731
LOC103469572	uba52	ENSPREP00000021110	ENSPREP00000016516	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.659
LOC103469572	ubl7	ENSPREP00000021110	ENSPREP00000008628	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin-like 7b (bone marrow stromal cell-derived).	0.407
LOC103469572	usp48	ENSPREP00000021110	ENSPREP00000029936	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family.	0.659
LOC103470505	LOC103469572	ENSPREP00000009694	ENSPREP00000021110	Ubiquitin like 4A.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.468
LOC103470505	LOC103473320	ENSPREP00000009694	ENSPREP00000028561	Ubiquitin like 4A.	TNF receptor-associated factor.	0.468
LOC103470505	LOC103473816	ENSPREP00000009694	ENSPREP00000022240	Ubiquitin like 4A.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.468
LOC103470505	rps27a	ENSPREP00000009694	ENSPREP00000018427	Ubiquitin like 4A.	Ribosomal protein S27a.	0.792
LOC103470505	trip12	ENSPREP00000009694	ENSPREP00000026747	Ubiquitin like 4A.	Thyroid hormone receptor interactor 12.	0.936
LOC103470505	uba52	ENSPREP00000009694	ENSPREP00000016516	Ubiquitin like 4A.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.851
LOC103470505	ubl7	ENSPREP00000009694	ENSPREP00000008628	Ubiquitin like 4A.	Ubiquitin-like 7b (bone marrow stromal cell-derived).	0.762
LOC103470505	usp13	ENSPREP00000009694	ENSPREP00000022602	Ubiquitin like 4A.	Ubiquitinyl hydrolase 1.	0.744
LOC103470505	usp48	ENSPREP00000009694	ENSPREP00000029936	Ubiquitin like 4A.	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family.	0.672
LOC103470505	usp5	ENSPREP00000009694	ENSPREP00000018558	Ubiquitin like 4A.	Ubiquitin carboxyl-terminal hydrolase.	0.712
LOC103473320	LOC103470505	ENSPREP00000028561	ENSPREP00000009694	TNF receptor-associated factor.	Ubiquitin like 4A.	0.468
LOC103473320	rps27a	ENSPREP00000028561	ENSPREP00000018427	TNF receptor-associated factor.	Ribosomal protein S27a.	0.731
LOC103473320	uba52	ENSPREP00000028561	ENSPREP00000016516	TNF receptor-associated factor.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.659
LOC103473320	ubl7	ENSPREP00000028561	ENSPREP00000008628	TNF receptor-associated factor.	Ubiquitin-like 7b (bone marrow stromal cell-derived).	0.407

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.908

expected number of edges:

10

PPI enrichment p-value:

9.94e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901621

Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

4 of 5

3.22

4.14

2.96e-08

GO:0010737

Protein kinase A signaling

4 of 12

2.84

3.7

1.42e-07

GO:0070613

Regulation of protein processing

4 of 40

2.32

2.75

4.52e-06

GO:0001843

Neural tube closure

4 of 43

2.29

2.73

4.61e-06

GO:0005513

Detection of calcium ion

2 of 4

3.02

1.64

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

5 of 15

2.84

5.04

3.67e-10

GO:0004691

cAMP-dependent protein kinase activity

4 of 6

3.14

4.43

8.14e-09

GO:0004679

AMP-activated protein kinase activity

4 of 7

3.07

4.41

8.53e-09

GO:0022839

Ion gated channel activity

4 of 36

2.36

3.05

1.17e-06

GO:0005267

Potassium channel activity

6 of 173

1.86

3.03

6.34e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097546

Ciliary base

4 of 25

2.52

3.19

8.61e-07

GO:0005813

Centrosome

4 of 419

1.3

0.83

0.0108

GO:0005886

Plasma membrane

11 of 5511

0.62

0.54

0.00010

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38343157

(2024) Identification of Philaster apodigitiformis in aquaculture and functional characterization of its beta-PKA gene and expression analysis of infected Poecilia reticulata.

4 of 4

3.32

4.83

1.67e-09

PMID:29491911

(2016) Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms.

4 of 5

3.22

4.82

1.67e-09

PMID:29104539

(2017) Annonaceae: Breaking the Wall of Inflammation.

4 of 9

2.97

4.47

5.66e-09

PMID:36430661

(2022) Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.

4 of 22

2.58

3.71

8.85e-08

PMID:27571066

(2016) Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis.

4 of 26

2.5

3.59

1.30e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26060

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and PKA activation in glucagon signalling

11 of 41

2.75

12.53

1.35e-26

CL:26127

Detection of calcium ion, and Calcium-activated BK potassium channel alpha subunit

5 of 6

3.24

6.17

5.11e-12

CL:26061

Cyclic nucleotide-dependent protein kinase activity, and PKA activation in glucagon signalling

5 of 33

2.5

4.29

4.42e-09

CL:26065

PKA activation in glucagon signalling, and Hormone-sensitive lipase, N-terminal

4 of 11

2.88

4.05

3.28e-08

CL:26068

PKA activation in glucagon signalling

3 of 6

3.02

2.94

4.34e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04270

Vascular smooth muscle contraction

7 of 128

2.06

4.64

1.15e-11

pret04540

Gap junction

5 of 103

2.0

3.22

8.02e-08

pret04340

Hedgehog signaling pathway

4 of 53

2.2

3.07

6.25e-07

pret04914

Progesterone-mediated oocyte maturation

4 of 88

1.98

2.57

3.29e-06

pret04912

GnRH signaling pathway

4 of 94

1.95

2.54

3.40e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-392517

Rap1 signalling

5 of 30

2.54

4.31

4.76e-09

MAP-164378

PKA activation in glucagon signalling

4 of 12

2.84

3.97

4.37e-08

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

4 of 13

2.81

3.96

4.37e-08

MAP-163359

Glucagon signaling in metabolic regulation

4 of 13

2.81

3.96

4.37e-08

MAP-8963896

HDL assembly

4 of 20

2.62

3.7

1.02e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0048471

Perinuclear region of cytoplasm

4 of 66

2.1

2.2

4.00e-05

GOCC:0005929

Cilium

4 of 396

1.32

0.74

0.0211

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

5 of 233

1.65

1.97

1.72e-05

KW-0067

ATP-binding

5 of 940

1.04

0.76

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03493

Calcium-activated BK potassium channel alpha subunit

4 of 4

3.32

4.59

4.60e-09

PF07885

Ion channel

4 of 91

1.96

1.95

0.00010

PF03185

Calcium-activated potassium channel, beta subunit

2 of 4

3.02

1.45

0.0024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044109

cAMP-dependent protein kinase catalytic subunit

4 of 4

3.32

4.32

1.44e-08

IPR003929

Calcium-activated potassium channel BK, alpha subunit

4 of 4

3.32

4.32

1.44e-08

IPR000961

AGC-kinase, C-terminal

5 of 66

2.2

3.23

2.69e-07

IPR003930

Potassium channel, calcium-activated, BK, beta subunit

2 of 4

3.02

1.35

0.0037

IPR008271

Serine/threonine-protein kinase, active site

5 of 369

1.45

1.26

0.00086

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

5 of 63

2.22

3.49

7.09e-08

SM00220

Serine/Threonine protein kinases, catalytic domain

5 of 273

1.58

1.77

4.33e-05

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