STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pip4k2cPhosphatidylinositol-5-phosphate 4-kinase, type II, gamma a. (418 aa)    
Predicted Functional Partners:
pip5k1c
Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a.
     
0.936
LOC103478143
Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b.
     
0.936
pikfyve
Phosphoinositide kinase, FYVE finger containing.
     
 0.918
synj1
Synaptojanin 1.
    
 0.917
LOC103480619
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
     
 0.916
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.911
inpp5e
Inositol polyphosphate-5-phosphatase E.
     
 0.911
inpp5b
Inositol polyphosphate-5-phosphatase B.
     
 0.907
rock2
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
    
  0.905
actn1
Actinin, alpha 1.
   
 
 0.902
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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