gpha2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

gpha2

Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (134 aa)

Predicted Functional Partners:

LOC103480754

0.883

Unc79

0.768

gpr1

0.645

LOC103464691

0.589

LOC103467433

0.589

clg9h12orf43

0.549

KLHL28

0.535

LOC103461037

0.533

mmab

0.526

pcnx1

0.470

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KLHL28	gpha2	ENSPREP00000032356	ENSPREP00000030124	Kelch like family member 28.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.535
KLHL28	pcnx1	ENSPREP00000032356	ENSPREP00000027643	Kelch like family member 28.	Pecanex 1.	0.549
LOC103461037	gpha2	ENSPREP00000019992	ENSPREP00000030124	RAN binding protein 2.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.533
LOC103464691	LOC103467433	ENSPREP00000017541	ENSPREP00000029078	Thyroid stimulating hormone subunit beta a.	Cys_knot domain-containing protein.	0.907
LOC103464691	LOC103480754	ENSPREP00000017541	ENSPREP00000030138	Thyroid stimulating hormone subunit beta a.	Si:dkey-23i12.9.	0.421
LOC103464691	gpha2	ENSPREP00000017541	ENSPREP00000030124	Thyroid stimulating hormone subunit beta a.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.589
LOC103467433	LOC103464691	ENSPREP00000029078	ENSPREP00000017541	Cys_knot domain-containing protein.	Thyroid stimulating hormone subunit beta a.	0.907
LOC103467433	LOC103480754	ENSPREP00000029078	ENSPREP00000030138	Cys_knot domain-containing protein.	Si:dkey-23i12.9.	0.421
LOC103467433	gpha2	ENSPREP00000029078	ENSPREP00000030124	Cys_knot domain-containing protein.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.589
LOC103480754	LOC103464691	ENSPREP00000030138	ENSPREP00000017541	Si:dkey-23i12.9.	Thyroid stimulating hormone subunit beta a.	0.421
LOC103480754	LOC103467433	ENSPREP00000030138	ENSPREP00000029078	Si:dkey-23i12.9.	Cys_knot domain-containing protein.	0.421
LOC103480754	gpha2	ENSPREP00000030138	ENSPREP00000030124	Si:dkey-23i12.9.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.883
Unc79	gpha2	ENSPREP00000021607	ENSPREP00000030124	Uncharacterized protein.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.768
clg9h12orf43	gpha2	ENSPREP00000029921	ENSPREP00000030124	Uncharacterized protein.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.549
clg9h12orf43	mmab	ENSPREP00000029921	ENSPREP00000033125	Uncharacterized protein.	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	0.442
gpha2	KLHL28	ENSPREP00000030124	ENSPREP00000032356	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Kelch like family member 28.	0.535
gpha2	LOC103461037	ENSPREP00000030124	ENSPREP00000019992	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	RAN binding protein 2.	0.533
gpha2	LOC103464691	ENSPREP00000030124	ENSPREP00000017541	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Thyroid stimulating hormone subunit beta a.	0.589
gpha2	LOC103467433	ENSPREP00000030124	ENSPREP00000029078	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Cys_knot domain-containing protein.	0.589
gpha2	LOC103480754	ENSPREP00000030124	ENSPREP00000030138	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Si:dkey-23i12.9.	0.883

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.871

expected number of edges:

10

PPI enrichment p-value:

0.000306

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033198

Response to ATP

5 of 14

2.87

5.17

2.21e-10

GO:0032732

Positive regulation of interleukin-1 production

4 of 34

2.39

2.96

1.91e-06

GO:0035590

Purinergic nucleotide receptor signaling pathway

4 of 36

2.36

2.93

2.13e-06

GO:0006812

Cation transport

11 of 975

1.37

2.43

7.37e-12

GO:0002931

Response to ischemia

3 of 17

2.56

2.32

4.77e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035381

ATP-gated ion channel activity

3 of 9

2.84

2.91

4.43e-06

GO:0005261

Cation channel activity

8 of 469

1.55

2.69

2.02e-09

GO:0015267

Channel activity

9 of 648

1.46

2.54

3.54e-10

GO:0008324

Cation transmembrane transporter activity

10 of 823

1.4

2.42

1.11e-10

GO:0001614

Purinergic nucleotide receptor activity

3 of 23

2.43

2.31

4.41e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005639

Integral component of nuclear inner membrane

3 of 12

2.72

2.35

4.73e-05

GO:0005921

Gap junction

3 of 43

2.16

1.91

0.00020

GO:0005911

Cell-cell junction

4 of 389

1.33

0.99

0.0036

GO:0030054

Cell junction

6 of 1752

0.85

0.59

0.0082

GO:0120025

Plasma membrane bounded cell projection

6 of 1857

0.83

0.57

0.0091

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43862

Nucleotide receptor activity, and TMEM119 family

7 of 24

2.78

7.35

6.66e-15

CL:43865

ATP P2X receptor, and Innexin

5 of 10

3.02

5.6

4.43e-11

CL:43868

ATP P2X receptor

2 of 5

2.92

1.25

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04621

NOD-like receptor signaling pathway

3 of 133

1.67

1.09

0.0054

pret04020

Calcium signaling pathway

3 of 250

1.4

0.8

0.0172

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112307

Transmission across Electrical Synapses

3 of 10

2.79

2.4

3.93e-05

MAP-112303

Electric Transmission Across Gap Junctions

3 of 10

2.79

2.4

3.93e-05

MAP-139853

Elevation of cytosolic Ca2+ levels

3 of 21

2.47

2.16

9.24e-05

MAP-844456

The NLRP3 inflammasome

3 of 27

2.36

2.04

0.00014

MAP-9730628

Sensory perception of salty taste

2 of 2

3.32

1.96

0.00030

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005639

Integral component of nuclear inner membrane

3 of 11

2.75

2.36

4.60e-05

GOCC:0005921

Gap junction

3 of 38

2.21

1.8

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0407

Ion channel

6 of 308

1.61

2.26

9.31e-07

KW-0303

Gap junction

3 of 41

2.18

2.16

5.96e-05

KW-0325

Glycoprotein

3 of 61

2.01

1.91

0.00014

KW-1071

Ligand-gated ion channel

2 of 63

1.82

0.94

0.0144

KW-1133

Transmembrane helix

11 of 5706

0.6

0.54

2.64e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00876

Innexin

3 of 4

3.19

2.86

6.58e-06

PF00864

ATP P2X receptor

3 of 7

2.95

2.71

1.13e-05

PF14798

Calcium homeostasis modulator

2 of 5

2.92

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039099

Pannexin

3 of 4

3.19

2.59

2.05e-05

IPR000990

Innexin

3 of 4

3.19

2.59

2.05e-05

IPR027309

P2X purinoreceptor extracellular domain superfamily

3 of 7

2.95

2.54

2.35e-05

IPR001429

P2X purinoreceptor

3 of 7

2.95

2.54

2.35e-05

IPR029569

Calcium homeostasis modulator family

2 of 5

2.92

1.22

0.0063

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