STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gchfrGTP cyclohydrolase I feedback regulator. (86 aa)    
Predicted Functional Partners:
gch1
GTP cyclohydrolase 1.
    
 0.976
LOC103481546
GTP cyclohydrolase 2.
    
 0.973
pts
6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
     
 0.794
spr
Sepiapterin reductase b.
      
 0.665
pcbd1
Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha.
   
  
 0.639
qdpr
Quinoid dihydropteridine reductase a.
   
  
 0.609
dnajc12
DnaJ (Hsp40) homolog, subfamily C, member 12.
      
 0.549
gpr143
G protein-coupled receptor 143.
      
 0.543
dct
Dopachrome tautomerase.
      
 0.533
akr1a1
Aldo-keto reductase family 1, member A1b (aldehyde reductase).
   
  
 0.528
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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