STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
LOC103473951Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2081 aa)    
Predicted Functional Partners:
Unc79
Uncharacterized protein.
   
 0.989
cacnb4
Calcium channel, voltage-dependent, beta 4a subunit.
   
 0.695
LOC103475101
Calcium channel, voltage-dependent, beta 4b subunit.
   
 0.695
CACNG2
Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
 
 0.667
LOC103467623
Calcium channel, voltage-dependent, beta 3a.
   
 0.666
cacnb2
Calcium channel, voltage-dependent, beta 2a.
   
 0.666
cacnb1
Calcium channel, voltage-dependent, beta 1 subunit.
   
 0.666
LOC103479890
Calcium channel, voltage-dependent, beta 2b.
   
 0.666
ENSPREP00000032722
Calcium channel, voltage-dependent, beta 3b.
   
 0.666
wdr35
WD repeat-containing protein 35.
    
 0.661
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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